The model contains three different isoforms of the calcium L- type channels (Cav1.2 α1-subunit, long and short Cav1.3 α1-subunit splice variants) according to the data and the descriptions of Ortner et al., 2017 J Neurosci. Since calcium overload confers the susceptibility of SNc neurons to neurodegeneration. our work described the impact of the those different L- type calcium isoforms in calcium accumulation, action potential firing and burst firing (NMDA-induced) of the SNc neurons.