COMMENT
//****************************//
// Created by Alon Polsky //
// apmega@yahoo.com //
// 2007 //
//****************************//
ENDCOMMENT
TITLE NMDA synapse
NEURON {
POINT_PROCESS nmda_spikes
USEION ca READ cai WRITE ica VALENCE 2
NONSPECIFIC_CURRENT inmda
RANGE e ,gmax,inmda
RANGE gnmda
GLOBAL n, gama,tau1,tau2
}
UNITS {
(nA) = (nanoamp)
(mV) = (millivolt)
(nS) = (nanomho)
(mM) = (milli/liter)
F = 96480 (coul)
R = 8.314 (volt-coul/degC)
}
PARAMETER {
gmax=1 (nS)
e= 0.0 (mV)
tau1=90 (ms): Was 90
tau2=5 (ms)
gama=0.08 :0.08 (/mV) :Was 0.08
dt (ms)
v (mV)
n=0.25 (/mM) :was 0.25
}
ASSIGNED {
inmda (nA)
gnmda (nS)
ica (mA/cm2)
cai (mM)
}
STATE {
A (nS)
B (nS)
}
INITIAL {
gnmda=0
A=0
B=0
}
BREAKPOINT {
SOLVE state METHOD cnexp
gnmda=(A-B)/(1+n*exp(-gama*v))
inmda = (1e-3) * gnmda * (v-e)
ica = inmda/10
}
DERIVATIVE state {
A'=-A/tau1
B'=-B/tau2
}
NET_RECEIVE (weight) {
gmax=weight
state_discontinuity( A, A+ gmax)
state_discontinuity( B, B+ gmax)
}