COMMENT
Kexternal - Based on Frankenhauser and Hodgkin, 1956; Kushmerick and Podolsky, 1969
ENDCOMMENT
NEURON {
SUFFIX kextern
RANGE wid, txfer, kinitial
USEION k READ ik WRITE ko
USEION na READ ina WRITE nao
}
UNITS {
(mM) = (milli/liter)
(um) = (micron)
FARADAY = (faraday) (coulomb)
(molar) = (1/liter)
PI = (pi) (1)
(mA) = (milliamp)
}
PARAMETER {
kinitial = 3.5 (mM)
nainitial = 135 (mM)
wid = 300 (angstrom) : 30x10-3 width
txfer = 150 (ms) : tau
}
ASSIGNED {
ik (mA/cm2)
ina (mA/cm2)
}
INITIAL {
ko = 3.5
nao = 135
}
STATE {
ko (mM)
nao (mM)
}
BREAKPOINT {
SOLVE state METHOD cnexp
}
DERIVATIVE state {
ko' = (1e8)*ik/(wid*FARADAY)+(kinitial-ko)/txfer
nao' = (1e8)*ina/(wid*FARADAY)+(nainitial-nao)/txfer
}