TITLE HH k channel channel
: Hodgkin - Huxley k channel
NEURON {
SUFFIX HHk
USEION k READ ek WRITE ik
RANGE gkbar, ik
GLOBAL inf, tau
}
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
}
PARAMETER {
gkbar=.00026 (mho/cm2) <0,1e9>
ek (mV) : -77 suggested, default set by NEURON
}
STATE {
n
}
ASSIGNED {
v (mV)
celsius (degC) : 16
ik (mA/cm2)
inf
tau (ms)
}
INITIAL {
rate(v*1(/mV))
n = inf
}
BREAKPOINT {
SOLVE states METHOD cnexp
ik = gkbar*n*n*n*n*(v - ek)
}
DERIVATIVE states { : exact when v held constant
rate(v*1(/mV))
n' = (inf - n)/tau
}
UNITSOFF
FUNCTION alp(v(mV)) { LOCAL q10
v = -v - 65
q10 = 3 : 3^((celsius - 6.3)/10)
alp = q10 * .01*expM1(v + 10, 10)
}
FUNCTION bet(v(mV)) { LOCAL q10
v = -v - 65
q10 = 3^((celsius - 6.3)/10)
bet = q10 * .125*exp(v/80)
}
FUNCTION expM1(x,y) {
if (fabs(x/y) < 1e-6) {
expM1 = y*(1 - x/y/2)
}else{
expM1 = x/(exp(x/y) - 1)
}
}
PROCEDURE rate(v) {LOCAL a, b :rest = -70
TABLE inf, tau DEPEND celsius FROM -100 TO 100 WITH 200
a = alp(v)/5 b=bet(v)/5
tau = 1/(a + b)
inf = a/(a + b)
}
UNITSON