: Rod Photoreceptor Kv channel
NEURON
{
SUFFIX Kv_cone
USEION Kv WRITE iKv VALENCE 1
RANGE gKv,gKvbar, eKv
}
UNITS
{
(mA) = (milliamp)
(mV) = (millivolt)
(mS) = (millimho)
}
PARAMETER
{
: potassium rectifier
gKvbar = 2.0 (mS/cm2) <0,1e9>
eKv = -80 (mV)
}
STATE
{
mKv
hKv
}
ASSIGNED
{
v (mV)
iKv (mA/cm2)
: potussium rectifier, K
infmKv
taumKv (ms)
infhKv
tauhKv (ms)
gKv (mho/cm2)
}
INITIAL
{
rate(v)
mKv = infmKv
hKv = infhKv
}
BREAKPOINT
{
SOLVE states METHOD cnexp
gKv = (0.001)*gKvbar*mKv*mKv*mKv *hKv
iKv = gKv*(v - eKv)
}
DERIVATIVE states
{
rate(v)
mKv' = (infmKv - mKv)/taumKv
hKv' = (infhKv - hKv )/tauhKv
}
UNITSOFF
FUNCTION alphamKv(v(mV)) (/ms)
{
alphamKv = (0.001)*5*(100-v)/( exp( (100-v)/42) -1 )
:alter from orginal settings where it is in the unit of 1/s
}
FUNCTION betamKv (v(mV)) (/ms)
{
betamKv = (0.001)*9*exp (- (v-20) /40 )
}
FUNCTION alphahKv (v(mV)) (/ms)
{
alphahKv = (0.001)*0.15 *exp (-v/22)
}
FUNCTION betahKv (v(mV)) (/ms)
{
betahKv = (0.001)*0.4125/( exp ( ( 10-v)/7 ) +1 )
}
UNITSON
PROCEDURE rate(v (mV))
{
LOCAL a, b
a = alphamKv(v)
b = betamKv(v)
taumKv = 1/(a + b)
infmKv = a/(a + b)
a = alphahKv(v)
b = betahKv(v)
tauhKv = 1/(a + b)
infhKv = a/(a + b)
}