: Cone Photoreceptor h channel by using kinetics in Barnes' paper
NEURON
{
SUFFIX h_cone
NONSPECIFIC_CURRENT ih
RANGE ghbar, gh, eh
}
UNITS
{
(mA) = (milliamp)
(mV) = (millivolt)
(mS) = (millimho)
}
PARAMETER
{
: h channel
ghbar = 3.5 (mS/cm2) <0,1e9>
eh = -32.5 (mV)
}
STATE
{
nh
}
ASSIGNED
{
v (mV)
ih (mA/cm2)
infh
tauh (ms)
gh (mho/cm2)
}
INITIAL
{
rate(v)
nh = infh
}
BREAKPOINT
{
SOLVE states METHOD cnexp
gh = (0.001)*ghbar*(1-(1+3*nh)*(1-nh)^3)
ih = gh*(v - eh)
: the current is in the unit of mA/cm2
}
DERIVATIVE states
{
rate(v)
nh' = (infh - nh )/tauh
}
FUNCTION alphah(v(mV)) (/ms)
{
alphah = 0.001*18/( exp ( ( v+88)/12 ) + 1 )
}
FUNCTION betah(v(mV)) (/ms)
{
betah = 0.001*18/( exp ( - ( v+18)/19 ) + 1 )
}
PROCEDURE rate(v (mV))
{
LOCAL a, b
a = alphah(v)
b = betah(v)
tauh = 1/(a + b)
infh = a/(a + b)
}