: Rod Photoreceptor Ca and Calcium channel
: Ref. Kourenny and Liu 2002 ABME 30 : 1196-1203
: Modification 2004-02-07
NEURON
{
SUFFIX Ca
USEION Ca WRITE iCa VALENCE 2
RANGE gCabar,VhalfCam,SCam
RANGE VhalfCah,SCah
RANGE eCa,aomCa,bomCa
RANGE gammaohCa,deltaohCa
}
UNITS
{
(mA) = (milliamp)
(mV) = (millivolt)
(mS) = (millimho)
(mol)= (1)
(M) = (mol/liter)
(uM) = (micro M)
}
PARAMETER
{
: Calcium channel
gCabar = 4 (mS/cm2) <0,1e9> :different from ABME paper
eCa = 40 (mV)
aomCa = 100 (/s) : changed from 3.10/s, 20/s
bomCa = 100 (/s)
gammaohCa = 10 (/s)
deltaohCa =10 (/s)
VhalfCam=-10.0 (mV)
VhalfCah=11 (mV)
SCam =6.0 (mV)
SCah =9 (mV)
}
STATE
{
mCa
hCa
}
ASSIGNED
{
gCa (mho/cm2)
v (mV)
iCa (mA/cm2)
infmCa
taumCa (ms)
infhCa
tauhCa (ms)
}
INITIAL
{
rate(v)
mCa = infmCa
hCa = infhCa
}
BREAKPOINT
{
SOLVE states METHOD cnexp
gCa = (0.001)*gCabar*mCa*hCa
: g is in unit of S/cm2 ,i is in unit of mA/cm2 and v is in mV
iCa = gCa*(v - eCa)
: the current is in the unit of mA/cm2
}
DERIVATIVE states
{
rate(v)
mCa' = (infmCa - mCa)/taumCa
hCa'= (infhCa-hCa)/tauhCa
}
FUNCTION alphamCa(v(mV))(/ms)
{
alphamCa = 0.001*aomCa*exp( (v - VhalfCam)/(2*SCam) )
}
FUNCTION betamCa(v(mV))(/ms)
{
betamCa = 0.001*bomCa*exp( - ( v-VhalfCam)/(2*SCam) )
}
FUNCTION gammahCa(v(mV))(/ms)
{
gammahCa = 0.001*gammaohCa*exp( (v - VhalfCah)/(2*SCah))
}
FUNCTION deltahCa(v(mV))(/ms)
{
deltahCa = 0.001*deltaohCa*exp( - ( v-VhalfCah)/(2*SCah) )
}
PROCEDURE rate(v (mV))
{
LOCAL a, b,c, d
a = alphamCa(v)
b = betamCa(v)
taumCa = 1/(a + b)
infmCa = a/(a + b)
c = gammahCa(v)
d = deltahCa(v)
tauhCa = 1/(c + d)
infhCa = d/(c + d)
}