TITLE Sodium transient current for RD Traub, J Neurophysiol 89:909-921, 2003
COMMENT
Implemented by Maciej Lazarewicz 2003 (mlazarew@seas.upenn.edu)
ENDCOMMENT
INDEPENDENT { t FROM 0 TO 1 WITH 1 (ms) }
UNITS {
(mV) = (millivolt)
(mA) = (milliamp)
}
NEURON {
SUFFIX nafsoma
USEION na READ ena WRITE ina
RANGE gbar, ina
RANGE v11, v22, v33, v44,fastNashift
}
PARAMETER {
fastNashift = 0: -3.5 (mV) : changed from -3.5
gbar = 0.0 (mho/cm2)
v ena (mV)
v11 = 62.9 (mV)
v22 = 10.7 (mV)
v33 = 37 (mV)
v44 = 10 (mV)
}
ASSIGNED {
ina (mA/cm2)
minf hinf (1)
mtau htau (ms)
}
STATE {
m h
}
BREAKPOINT {
SOLVE states METHOD cnexp
ina = gbar * m * m * m * h * ( v - ena )
}
INITIAL {
settables( v - fastNashift )
m = minf
m = 0
h = hinf
}
DERIVATIVE states {
:settables( v )
minf = 1 / ( 1 + exp( ( - ( v + fastNashift ) - 30 ) / 10 ) ) :Original value .015
if( ( v + fastNashift ) < -28.0 ) {
mtau = 0.025 + 0.14 * exp( ( ( v + fastNashift ) + 28 ) / 10 )
} else{
mtau = 0.02 + 0.145 * exp( ( - ( v + fastNashift ) - 30 ) / 10 )
}
hinf = 1 / ( 1 + exp( ( ( v + fastNashift ) + v11 ) / v22 ) ) : Original value 0.08
htau = 0.15 + 1.15 / ( 1 + exp( ( ( v + fastNashift )+ v33 ) / v44 ) ) : Original value 0.15
m' = ( minf - m ) / mtau
h' = ( hinf - h ) / htau
}
UNITSOFF
PROCEDURE settables(v1(mV)) {
TABLE minf, hinf, mtau, htau FROM -120 TO 40 WITH 641
minf = 1 / ( 1 + exp( ( - ( v1 + fastNashift ) - 30 ) / 10 ) ) :Original value .015
if( ( v1 + fastNashift ) < -28.0 ) {
mtau = 0.025 + 0.14 * exp( ( ( v1 + fastNashift ) + 28 ) / 10 )
} else{
mtau = 0.02 + 0.145 * exp( ( - ( v1 + fastNashift ) - 30 ) / 10 )
}
: hinf, and htau are shifted 3.5 mV comparing to the paper
: if( (v1 + fastNashift ) < - 43.0 ){ : This shifts the behavior of the inactivation particle
: hinf = .15 + 1 / ( 1 + exp( ( ( v1 + fastNashift * 0 ) + 62.9 ) / 10.7) ) :(.15)
: }else{
: hinf = 1 / ( 1 + exp( ( ( v1 + fastNashift * 0 ) + 62.9 ) / 10.7 ) )
: }
: htau = 2*(0.15 + 1.15 / ( 1 + exp( ( ( v1 + fastNashift * 0 ) + 37 ) / 10 ) )) :The first factor is to slow down hinf
hinf = 1 / ( 1 + exp( ( ( v1 + fastNashift ) + v11 ) / v22 ) ) : Original value 0.08
htau = 0.15 + 1.15 / ( 1 + exp( ( ( v1 + fastNashift )+ v33 ) / v44 ) ) : Original value 0.15
}
UNITSON