This is the README file for the model & meshes associated with the paper:

Denizot, A., M. Arizono, U. V. Nägerl, H. Berry, & E. De Schutter. Control of Ca2+ signals by astrocyte nanoscale morphology at tripartite synapses, Glia, Sep. 2022, doi: 10.1002/glia.24258


We present here 2 different implementations of the model, described below, as well as the 3D meshes that have been designed to reproduce realistic geometries of astrocytic branchlets of the gliapil.


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##### Bleaching ######
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Simulations that reproduce bleaching experiments from Arizono et al., Nature Communications, 2020. In those simulations, ZSGreen molecules diffuse in the astrocytic branchlet. At t=t0=300ms, 60 % of ZSGreen molecules are bleached. For more details, please refer to Denizot et al., Glia, 2022.


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### successivestim ###
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Simulations in which calcium signals are monitored in Node 5 while nodes 1-4 are successively stimulated, with a probability of stimulation failure proba_fail. Please refer to the manuscript for more details.
The model of calcium dynamics is from Denizot et al., PLOS Computational Biology, 2019 (code available at: https://senselab.med.yale.edu/modeldb/ShowModel?model=247694#tabs-1)


Contact:
audrey.denizot3@oist.jp