/////////////////////////////////////////////////////////////////////
// section name and topology
{load_file("rgc-ctt3219m.asc")}
objref dendrites
dendrites = new SectionList()
dend1 dendrites.append()
dend2 dendrites.append()
forall {
//ensure odd nseg count
if (nseg % 2 == 0) {
nseg += 1
}
}
soma {
diam = 11.6502 //hard spec
nseg = 5
}
ah[0] {
diam = 3 //hard spec
L = 40 //hard spec
nseg = 15
}
/////////////////////////////////////////////////////////////////////
// additional geometry for ais narrowr axon
create ais, narrowr, axon
ais {
diam = 0.8
L = 40
nseg = 15
}
narrowr {
diam = 0.8
L = 90
nseg = 15
}
axon {
diam = 1
L = 5300
nseg = int(L/7)
}
connect ais(0), ah[0](1)
connect narrowr(0), ais(1)
connect axon(0), narrowr(1)
define_shape()
/////////////////////////////////////////////////////////////////////
// biophysics
forall insert pas
forall insert spike
forall ena = 35.0
forall ek = -75
forall insert cad
forall g_pas = 0.000005
forall e_pas = -62.5
forall Ra=110
forsec dendrites {
gnabar_spike = 0.025
gkbar_spike = 0.012
gabar_spike = 0.036
gcabar_spike = 0.002
gkcbar_spike = 0.000001
}
soma {
gnabar_spike = 0.070
gkbar_spike = 0.018
gabar_spike = 0.054
gcabar_spike = 0.0015
gkcbar_spike = 0.000065
}
ah[0] {
gnabar_spike = 0.070
gkbar_spike = 0.018
gabar_spike = 0.054
gcabar_spike = 0.0015
gkcbar_spike = 0.000065
}
ais {
gnabar_spike = 2.100 //30x of soma
gkbar_spike = 0.054 //matched
gabar_spike = 0.054
gcabar_spike = 0.0015
gkcbar_spike = 0.000065
}
narrowr {
gnabar_spike = 0.100
gkbar_spike = 0.018
gabar_spike = 0.054
gcabar_spike = 0.0015
gkcbar_spike = 0.000065
}
axon {
gnabar_spike = 0.070
gkbar_spike = 0.018
gabar_spike = 0
gcabar_spike = 0
gkcbar_spike = 0.000065
}
access soma
forall depth_cad = diam / 2