INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}
NEURON {
SUFFIX Cad
USEION Ca READ iCa, Cai WRITE Cai,Cao VALENCE 2
RANGE Ca, depth, Cainf, taur, entryF
}
UNITS {
(molar) = (1/liter) : moles do not appear in units
(mM) = (millimolar)
(um) = (micron)
(mA) = (milliamp)
(msM) = (ms mM)
FARADAY = (faraday) (coulomb)
}
PARAMETER {
depth = .1 (um) : depth of shell
taur = 200 (ms) : rate of calcium removal
Cainf = 2e-3 (mM) : 2uM
Cai (mM)
Cao = 2 (mM)
entryF = 1
}
STATE {
Ca (mM)
}
INITIAL {
Ca = Cainf
Cao=2
}
ASSIGNED {
iCa (mA/cm2)
drive_channel (mM/ms)
}
BREAKPOINT {
SOLVE state METHOD derivimplicit
}
DERIVATIVE state {
drive_channel = - (10000) * iCa / (2 * FARADAY * depth)
if (drive_channel <= 0.) { drive_channel = 0. } : cannot pump inward
:ca' = drive_channel + (cainf-ca)/taur
:Ca' = drive_channel/18 + (Cainf -Ca)/taur*7
Ca' = entryF*drive_channel/2 + (Cainf-Ca)/taur
Cai = Ca
Cao=2 :mM
}