load_file("nrngui.hoc")
load_proc ("nrnmainmenu")
create soma, bp, bp2
soma {L=25 diam=25 nseg=2}
bp {L=10 diam=10 nseg=1}
bp2 {L=10 diam=10 nseg=1}
// Pre synaptic mechanisms (L channel and Voltage Clamp)
access bp
insert cad
insert gfbp
access bp2
insert cad
insert gfbp
objectvar synapse[50]
access soma
insert spike
gcabar_spike = 0.0015
gkbar_spike = 0.018
gabar_spike = 0.054
gkcbar_spike = 0.000065
gnabar_spike = 0.10
insert cas
for i=0, 49{
synapse[i] = new ribbon_ca(0.5)
setpointer synapse[i].preCA1,bp.cai(0.5)
setpointer synapse[i].preCA2,bp2.cai(0.5)
}
objectvar somaclamp
somaclamp=new VClamp(0.5)
soma{
mod_modulator = 0
ena=35
ek=-75
cao=1.8
cai=.0001
insert pas
g_pas= 1/70000
Ra=110
global_ra=110
e_pas=-65
}
// Pre synaptic mechanisms (L channel and Voltage Clamp)
access bp // Full RRP
insert pas
g_pas= 1/70000
Ra=110
global_ra=110
e_pas=-65
depth_cad = 0.025
taur_cad=0.8
gcabar_gfbp = 0.0012
objectvar bpclamp
bpclamp = new VClamp2(0.5)
access bp2 // Less than Full RRP
insert pas
g_pas= 1/70000
Ra=110
global_ra=110
e_pas=-65
depth_cad = 0.05
taur_cad=0.18
gcabar_gfbp = 0.0012
objectvar bpclamp2
bpclamp2 = new VClamp2(0.5)
RIN = 0.125
TR = 0.8
TR2 = 0.18
MAXRVP=5
GCABP = 0.0016
GCABP2 = 0.0016
dcad1 = 0.025
dcad2 = 0.050
// RS = 2.84985
proc set_stim(){
for i = 0, 49 {
synapse[i].rate_constantIN = RIN
synapse[i].Max_RVP = MAXRVP
// synapse[i].S = RS
}
bp.taur_cad = TR
bp2.taur_cad = TR2
bp.gcabar_gfbp = GCABP
bp2.gcabar_gfbp = GCABP2
bp.depth_cad = dcad1
bp2.depth_cad = dcad2
}
objectvar vbox,vbox3, tempobj3
proc rate_panel(){
vbox3 = new VBox()
vbox3.intercept(1)
xpanel("")
xvalue("RC IN","RIN",1, "set_stim()")
xvalue("Taur BP","TR",1, "set_stim()")
xvalue("Taur BP-2","TR2",1, "set_stim()")
xvalue("MAX RVP","MAXRVP",1, "set_stim()")
xvalue("gcabar bp","GCABP",1, "set_stim()")
xvalue("gcabar bp2","GCABP2",1, "set_stim()")
xvalue("depth_cad bp","dcad1",1, "set_stim()")
xvalue("depth_cad bp2","dcad2",1, "set_stim()")
// xvalue("R&S rateout","RS",1, "set_stim()")
xpanel()
vbox3.intercept(0)
vbox3.map
}