: K-AHP-current, Stacey, Durand 2000
: eK from Martina
UNITS
{
(mA) = (milliamp)
(mV) = (millivolt)
(S) = (siemens)
(molar) = (1/liter)
}
NEURON {
SUFFIX KAHP
USEION k WRITE ik
USEION ca2 READ ca2i VALENCE 2.0
RANGE gAHPbar, gAHP
GLOBAL qinf, qtau
}
PARAMETER
{
gAHPbar = 0.0033 (S/cm2) <0,1e9>
eK = -95 (mV)
: cai2 = 0.13 (micromolar) <0,1e9>
: see warman
qtau = 48 (ms)
:no temperature dependence included
}
STATE
{
q
}
ASSIGNED
{
v (mV)
celsius (degC)
gAHP (S/cm2)
ik (mA/cm2)
qinf
ca2i (millimolar)
}
BREAKPOINT
{
SOLVE states METHOD cnexp
gAHP = gAHPbar*q
ik = gAHP*(v - eK)
}
INITIAL
{
rates(v)
q = qinf
}
DERIVATIVE states
{
rates(v)
q' = (qinf-q)/qtau
}
LOCAL q10
PROCEDURE rates(v(mV)) :Computes rate and other constants at current v.
:Call once from HOC to initialize inf at resting v.
{
LOCAL alpha, beta, sum
UNITSOFF
q10 = 3^((celsius - 6.3)/10)
:"q" potassium activation system
alpha = 0.0048 / exp((10 * log10(ca2i*1000)-35)/-2)
beta = 0.012 / exp((10 * log10(ca2i*1000)+100) / 5)
sum = alpha + beta
qinf = alpha/sum
}
FUNCTION vtrap(x,y) { :Traps for 0 in denominator of rate eqns.
if (fabs(x/y) < 1e-6) {
vtrap = y*(1 - x/y/2)
}else{
vtrap = x/(exp(x/y) - 1)
}
}
UNITSON