## Set file for rubinetal_resp_cpg_NaP_added.ode on Thu Jun 2 17:19:22 2016 20 Number of equations and auxiliaries 64 Number of parameters # Numerical stuff 1 nout 40 nullcline mesh 8 Qual RK 25000 total 0.1 DeltaT 0 T0 10000 Transient 5000 Bound 1e-12 DtMin 1 DtMax 0.00001 Tolerance 0.00001 Abs. Tolerance 0 Max Delay 100 Eigenvector iterates 0.001 Eigenvector tolerance 0.001 Newton tolerance 0 Poincare plane 1e-05 Boundary value tolerance 1e-05 Boundary value epsilon 20 Boundary value iterates 0 Poincare None 1 Poincare variable 1 Poincare sign 0 Stop on Section 0 Delay flag 10000 Current time 10000 Last Time 1 MyStart 1 INFLAG # Delays 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 # Bndry conds 0 0 0 0 0 0 0 0 0 0 0 # Old ICs -60.66742063215683 V1 -55.15919855536387 V2 -28.8868572708057 V3 -55.19831170723084 V4 0.2596807420292297 H1 0.2033427754553293 H2 0.4960826935839792 H3 0.4337940074659155 H4 0.266625030478492 M2 0.1272788027867369 M3 0.0350532299984076 M4 # Ending ICs -52.84739155518387 V1 -43.29209271556049 V2 -38.10366918617883 V3 -38.2925121574395 V4 0.462077254168296 H1 0.2816964053476461 H2 0.3568875503728695 H3 0.3752555725365055 H4 0.1288247945407498 M2 0.2022679212250763 M3 0.05229744268835267 M4 # Parameters 20 C 3 gLE 3.25 gLI -65 ELE -60 ELI 10 gsynE 0 EsynE 60 gsynI -75 EsynI -85 EK 50 ENa -29 V12n -4 kn 1 gKdr -37 V12mp -6 kmp -48 V12hp 8 khp 4000 tauhp 4.5 gNaPe 0.25 gNaPi 10 gAD 2000 Tad2 1500 Tad3 2000 Tad4 0.8 Kad2 1.4 Kad3 0.8 Kad4 -32 V12outpute -8 Koutpute -30 V12outputi -4 Koutputi 0.6 a12 0.6 b23 0.3 b24 0.125 b31 0.27 b32 0.45 b34 0.015 b41 0.3 b42 0.05 b43 1 Drive1 1 Drive2 1 Drive3 0.01 c11 0.19 c12 0.58 c13 0.2 c14 0.07000000000000001 c21 0.3 c22 0.4 c24 0.025 c31 1 nf 0 sdum1 0 sdum2 0 sdum3 0 sdum4 0 edum 0 Iapp1 0 Iapp2 0 Iapp3 0 Iapp4 1.0 pharmP 1.0 pharmB # Graphics 0.7071097251469876 rm -0.4999999999826661 rm 0.4999958366025516 rm 0.7071038372138505 rm 0.5000041633974482 rm -0.4999999999826661 rm 0 rm 0.7071038372138505 rm 0.7071097251469876 rm 0 17 1 1 0 0 18 1 1 1 0 19 1 1 8 0 20 1 1 10 0 1 1 1 0 0 1 1 1 0 0 1 1 1 0 0 1 1 1 0 0 1 1 1 0 0 1 1 1 0 -1000 1000 0 0 3DFlag 1 Timeflag 0 Colorflag 0 Type 1 color scale 0 minscale 10000 xmax 0 xmin 0.9216884970664978 ymax 0.0001775066048139706 ymin 12 zmax -12 zmin 5000 0.0002 0.4609330018356559 2.170348504468715 0 0.08333333333333333 45 Theta 45 Phi 0 xshft 0 yshft 0 zshft 0 xlo 0.0001775066048139706 ylo 0 -80 10000 xhi 0.9216884970664978 yhi 1000 20 # Transpose variables etc V1 2 n columns 1 n rows 1 row skip 1 col skip 1 row 0 # Coupling stuff for H funs 0 0 0 0 0 0 0 0 0 0 0 # Array plot stuff 1 NCols 0 Row 1 50 NRows 8 RowSkip 0 Zmin 1 Zmax # Torus information 0 Torus flag 1=ON 6.283185307179586 Torus period # Range information C -1 eq-range stab col 0 shoot flag 1=on 10 eq-range steps 0 eq_range low 1 eq_range high b31 V1 14 Range steps 0 Cycle color 1=on 0 Reset data 1=on 1 Use old I.C.s 1=yes 0.1 Par1 low 0 Par2 low 0.52 Par1 high 1 Par2 high C 0 BVP side 0 color cycle flag 1=on 10 BVP range steps 0 BVP range low 1 BVP range high RHS etc ... dV1/dT=(-INAPE(V1,H1)-IKDR(V1)-ILE(V1)-GSYNI*(B31*FOUTI(V3)+B41*FOUTI(V4)+SDUM1)*(V1-ESYNI)-GSYNE*(C11*DRIVE1+C21*DRIVE2+C31*DRIVE3)*(V1-ESYNE))/C dV2/dT=(-INAPI(V2,H2)-IAD(V2,M2)-ILI(V2)-GSYNI*(B32*FOUTI(V3)+B42*FOUTI(V4)+SDUM2)*(V2-ESYNI)-GSYNE*(A12*FOUTE(V1)+C22*DRIVE2+C12*DRIVE1+EDUM)*(V2-ESYNE))/C dV3/dT=(-INAPI(V3,H3)-IAD(V3,M3)-ILI(V3)-GSYNI*(B23*FOUTI(V2)+B43*FOUTI(V4)+SDUM3)*(V3-ESYNI)-GSYNE*(C13*DRIVE1)*(V3-ESYNE))/C dV4/dT=(-INAPI(V4,H4)-IAD(V4,M4)-ILI(V4)-GSYNI*(B24*FOUTI(V2)+B34*FOUTI(V3)+SDUM4)*(V4-ESYNI)-GSYNE*(C14*DRIVE1+C24*DRIVE2)*(V4-ESYNE))/C dH1/dT=(HPINF(V1)-H1)/TAUINF(V1) dH2/dT=(HPINF(V2)-H2)/TAUINF(V2) dH3/dT=(HPINF(V3)-H3)/TAUINF(V3) dH4/dT=(HPINF(V4)-H4)/TAUINF(V4) dM2/dT=(-M2+KAD2*FOUTI(V2))/TAD2 dM3/dT=(-M3+KAD3*FOUTI(V3))/TAD3 dM4/dT=(-M4+KAD4*FOUTI(V4))/TAD4 INH1=B31*FOUTI(V3)+B41*FOUTI(V4) INH2=B32*FOUTI(V3)+B42*FOUTI(V4) INH3=B23*FOUTI(V2)+B43*FOUTI(V4) INH4=B24*FOUTI(V2)+B34*FOUTI(V3) EXC2=A12*FOUTE(V1) FV1=FOUTE(V1) FV2=FOUTI(V2) FV3=FOUTI(V3) FV4=FOUTI(V4) User-defined functions: FOUTE(V) = 1./(1+EXP((V-V12OUTPUTE)/KOUTPUTE)) FOUTI(V) = 1./(1+EXP((V-V12OUTPUTI)/KOUTPUTI)) NINF(V) = 1./(1+EXP((V-V12N)/KN)) MPINF(V) = 1./(1+EXP((V-V12MP)/KMP)) HPINF(V) = 1./(1+EXP((V-V12HP)/KHP)) TAUINF(V) = TAUHP/COSH((V-V12HP)/(2*KHP)) INAPE(V,H) = GNAPE*MPINF(V)*H*(V-ENA) INAPI(V,H) = GNAPI*MPINF(V)*H*(V-ENA) IKDR(V) = GKDR*NINF(V)^4*(V-EK) IAD(V,M) = GAD*M*(V-EK) ILE(V) = GLE*(V-ELE) ILI(V) = GLI*(V-ELI)