COMMENT
changed from (AS Oct0899)
ca.mod to lead to thalamic ca current inspired by destexhe and huguenrd
Uses fixed eca instead of GHK eqn
ENDCOMMENT
INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}
NEURON {
SUFFIX it2
USEION ca READ eca WRITE ica
RANGE m, h, gcaT, icaT, gcabar
RANGE minf, hinf, mtau, htau, inactF, actF
GLOBAL vshift,vmin,vmax, v12m, v12h, vwm, vwh, am, ah, vm1, vm2, vh1, vh2, wm1, wm2, wh1, wh2
}
PARAMETER {
gcabar = 8 (pS/um2) : 0.12 mho/cm2
vshift = 0 (mV) : voltage shift (affects all)
cao = 2.0 (mM) : external ca concentration
cai (mM)
v (mV)
dt (ms)
celsius (degC)
vmin = -120 (mV)
vmax = 100 (mV)
v12m=50 (mV)
v12h=78 (mV)
vwm =7.4 (mV)
vwh=5.0 (mV)
am=3 (mV)
ah=85 (mV)
vm1=25 (mV)
vm2=100 (mV)
vh1=46 (mV)
vh2=405 (mV)
wm1=20 (mV)
wm2=15 (mV)
wh1=4 (mV)
wh2=50 (mV)
}
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
(pS) = (picosiemens)
(um) = (micron)
FARADAY = (faraday) (coulomb)
R = (k-mole) (joule/degC)
PI = (pi) (1)
}
ASSIGNED {
ica (mA/cm2)
icaT (mA/cm2)
gcaT (pS/um2)
eca (mV)
minf hinf
mtau (ms) htau (ms)
tadj
}
STATE { m h }
INITIAL {
trates(v+vshift)
m = minf
h = hinf
}
BREAKPOINT {
SOLVE states
gcaT = gcabar*m*m*h
icaT = gcaT *(1e-4)* (v - eca)
ica = icaT
}
LOCAL mexp, hexp
PROCEDURE states() {
trates(v+vshift)
m = m + mexp*(minf-m)
h = h + hexp*(hinf-h)
VERBATIM
return 0;
ENDVERBATIM
}
PROCEDURE trates(v) {
LOCAL tinc
TABLE minf, mexp, hinf, hexp
DEPEND dt
FROM vmin TO vmax WITH 199
rates(v): not consistently executed from here if usetable == 1
tinc = -dt
mexp = 1 - exp(tinc/mtau)
hexp = 1 - exp(tinc/htau)
}
PROCEDURE rates(v_) {
LOCAL a, b
minf = 1.0 / ( 1 + exp(-(v_+v12m)/vwm) )
hinf = 1.0 / ( 1 + exp((v_+v12h)/vwh) )
mtau = ( am + 1.0 / ( exp((v_+vm1)/wm1) + exp(-(v_+vm2)/wm2) ) )
htau = ( ah + 1.0 / ( exp((v_+vh1)/wh1) + exp(-(v_+vh2)/wh2) ) )
}