objref G1,vVec,indVec,nc, nil,apVec,G2,fn,voltMat,voltVec,axonVec,axonMat,dendVec,dendMat,stateMatNa,stateMatMut,stateMatNax
getcwd()
proc runSCN2A(){
voltMat = new Matrix(100.01/dt,1000)
axonMat = new Matrix(100.01/dt,1000)
dendMat = new Matrix(100.01/dt,1000)
inactAtVinitRation = 1
simnum=0
counter = 0
soma nc = new NetCon(&v(.5), nil)
nc.threshold = -5 // watch out! only one threshold per presyn location
apVec = new Vector(1100)
indVec = new Vector()
nc.record(indVec)
G1 = new Graph()
na_somaOrig = na_soma1
na_aisOrig = na_ais1
nax_aisOrig1 = 7000/2
nax_nodeOrig1 = 7000/2
nax_collatOrig1 = 500/2
nax_myelinOrig1 = 40/2
nax_aisOrig = 7000/2
nax_nodeOrig = 7000/2
nax_collatOrig = 500/2
nax_myelinOrig = 40/2
//het at proximal ais
na_soma1 = na_somaOrig*0
na_ais1 = na_aisOrig*0
init()
for (aa=0.99;aa>=0.9;aa-=0.1){
spaitialInd = aa
//actually na parameters in mod file and not nax
nax_ais = nax_aisOrig
nax_node = 0
nax_collat = 0
nax_myelin = 0
nax_ais1 = nax_aisOrig1*(2)
nax_node1 = nax_nodeOrig1*(2)
nax_collat1 = nax_collatOrig1*(2)
nax_myelin1 = nax_myelinOrig1*(2)
IClamp[0].amp = 0.5
init_channels()
counter = 0
printf("runing %f %% of Na density\n",aa*100)
//na_soma = 0.5*500
tstop = 600
IClamp[0].del = 500
IClamp[0].dur = 100
voltVec = new Vector(10001)
axonVec = new Vector(10001)
dendVec = new Vector(10001)
p = 0
flg0 = 1
flg1 = 1
while(IClamp[0].amp<=3){
init()
timeSteps = (tstop-t)/dt
counter=0
printf("runing %f",IClamp[0].amp)
while (t<tstop) {
G1.line(t,v(0.5))
voltVec.x(counter) = v(0.5)
axonVec.x(counter) = axon[0].v(1)
dendVec.x(counter) = apic[37].v(0.5)
if(v(0.5)>-10 && flg0){
print "soma ap"
flg0 = 0
}
if(axon[0].v(1)>-10&& flg1){
print "ap axon"
flg1 = 0
}
if(apic[37].v(0.5)>-10 ){
print "dend ap"
flg0 = 0
}
fadvance()
counter+=1
}
IClamp[0].amp +=0.05
printf("printing %f %f\n",aa,simnum)
voltMat = voltMat.setcol(simnum,voltVec)
axonMat = axonMat.setcol(simnum,axonVec)
dendMat = dendMat.setcol(simnum,dendVec)
simnum +=1
}
G1.flush()
//apVec.x(simnum) = IClamp[0].amp
//printf("somaCurrent1.amp is %f\n",apVec.x(simnum))
//apVec.x(simnum) = somaCurrent1.amp
}
fn = new File()
fn.wopen("Volts.csv")
voltMat.fprint(fn,"%f,","\n")
fn.close()
fn.wopen("VoltsAxon.csv")
axonMat.fprint(fn,"%f,","\n")
fn.close()
fn.wopen("VoltsDend.csv")
dendMat.fprint(fn,"%f,","\n")
fn.close()
}
/*
proc printStates(){
voltMat = new Matrix(100.01/dt,200)
stateMatNa = new Matrix(100.01/dt,3)
stateMatNax = new Matrix(100.01/dt,3)
stateMatMut = new Matrix(100.01/dt,3)
inactAtVinitRation = 0.93
simnum=0
counter = 0
soma nc = new NetCon(&v(.5), nil)
nc.threshold = -5 // watch out! only one threshold per presyn location
apVec = new Vector(1100)
indVec = new Vector()
nc.record(indVec)
G1 = new Graph()
Kv_soma1 = Kv_soma
Kv1_soma1 = Kv1_soma
Kv7_soma1 = Kv7_soma
Kv1_ais1 = Kv1_ais
Kv7_ais1 = Kv7_ais
na_soma1 = na_soma
na_ais1 = na_ais
init()
for (aa=10;aa<=10;aa+=.5){
IClamp[0].amp = 0
counter = 0
printf("runing %f/10 of Na density\n",aa)
tstop = 600
IClamp[0].del = 500
IClamp[0].dur = 100
IClamp[0].amp = 1.7
voltVec = new Vector(10001)
p = 0
flg0 = 1
flg1 = 1
while(IClamp[0].amp<=1.7){
init()
timeSteps = (tstop-t)/dt
counter=0
printf("runing %f",IClamp[0].amp)
while (t<tstop) {
G1.line(t,v(0.5))
voltVec.x(counter) = v(0.5)
stateMatNa.x(counter,0) = axon[0].c1_na(0.2)+axon[0].c2_na(0.2)+axon[0].c3_na(0.2)
stateMatNax.x(counter,0) = axon[0].c1_nax(0.4)+axon[0].c2_nax(0.4)+axon[0].c3_nax(0.4)
stateMatMut.x(counter,0) = axon[0].c1_nad12n(0.2)+axon[0].c2_nad12n(0.2)+axon[0].c3_nad12n(0.2)
stateMatNa.x(counter,1) = axon[0].i1_na(0.2)+axon[0].i2_na(0.2)+axon[0].i3_na(0.2)+axon[0].i4_na(0.2)
stateMatNax.x(counter,1) = axon[0].i1_nax(0.4)+axon[0].i2_nax(0.4)+axon[0].i3_nax(0.4)+axon[0].i4_nax(0.4)
stateMatMut.x(counter,1) = axon[0].i1_nad12n(0.2)+axon[0].i2_nad12n(0.2)+axon[0].i3_nad12n(0.2)+axon[0].i4_nad12n(0.2)
stateMatNa.x(counter,2) = axon[0].o_na(0.2)
stateMatNax.x(counter,2) = axon[0].o_nax(0.4)
stateMatMut.x(counter,2) = axon[0].o_nad12n(0.2)
if(v(0.5)>-10 && flg0){
print "soma ap"
flg0 = 0
}
if(axon[0].v(1)>-10&& flg1){
print "ap axon"
flg1 = 0
}
if(apic[37].v(0.5)>-10 ){
print "dend ap"
flg0 = 0
}
fadvance()
counter+=1
}
IClamp[0].amp +=0.1
printf("printing %f %f\n",aa,simnum)
voltMat = voltMat.setcol(simnum,voltVec)
simnum +=1
}
G1.flush()
//apVec.x(simnum) = IClamp[0].amp
//printf("somaCurrent1.amp is %f\n",apVec.x(simnum))
//apVec.x(simnum) = somaCurrent1.amp
}
fn = new File()
fn.wopen("VoltsStates.csv")
voltMat.fprint(fn,"%f,","\n")
fn.close()
fn = new File()
fn.wopen("StatesNa.csv")
stateMatNa.fprint(fn,"%f,","\n")
fn.close()
fn = new File()
fn.wopen("StatesNaMut.csv")
stateMatMut.fprint(fn,"%f,","\n")
fn.close()
fn = new File()
fn.wopen("StatesNax.csv")
stateMatNax.fprint(fn,"%f,","\n")
fn.close()
}
*/