//genesis //SynParamsCtx.g str AMPAname = "AMPA" float EkAMPA = 0.0 float AMPAtau1 = 1.1e-3 //wolf with qfact of 2 taken into account (t1 and t2) //float AMPAtau2 = 5.75e-3 //these tau are quite slow compared to hippocampal values //float AMPAgmax = 0.51e-9 // 45 mV PSP, AP calcium trivial compared to PSP //float AMPAtau1=0.2e-3 float AMPAtau2=2.0e-3 // double hippo values; faster than GABA float AMPAgmax=0.125e-9 //0.15 0.19 25 mV PSP, AP calcium higher than PSP calcium 0.342e-9 float AMPACaper = 0.00 //0.001 //percent AMPA conductance that is carried by calcium. value from wolf //more like 2/1 for thalamus so should be 0.47e-9 for thalamo-striatal syanpnse if NMDA is 0.94e-9 Rebekah Evans 6/25/10 float AMPAdes = 1 // 1 //desensitization factor, (depr_per_spike field of facsynchan) float AMPAdestau = 100e-3 // 100e-3 // desensitization tau (how fast des recovers) float depr = 1 float deprtau = 100e-3 str GABAname = "GABA" float GABAtau1 = 0.25e-3 // From Galarreta and Hestrin 1997 float GABAtau2 = 80.75e-3 //(used in Wolfs model) float EkGABA = -0.060 //calculated Kerr and Plenz 2004 Erev for Cl, is -60 mV 5/2/12 RCE float GABAgmax = 5000e-12 //was 750, Sri uses 900 //Modified Koos 2004 (Wolf uses 435e-12)//5000 if GABAtau2 is 75 ms (NPY neurons) //10000e-12 if GABAtau2 is 3.75ms float GABAdelay = 0.015 int ghk_yesno=1 //0 no ghk objects for NMDA, 1 add ghk to NMDA //ghk reduction factor and hoook ups to calcium shells are in Addsynapticchannels.g // parameters for NMDA subunits // cortex str subunit = "ctx" float EkNMDA = 0 float Kmg = 18 //18 new //3.57 old overwrites 1/eta in nmda_channel.g if ({subunit}=="NR2A") float NMDAtau2 = {(50e-3)/2} elif ({subunit}=="NR2B") float NMDAtau2 = (300e-3)/2 elif ({subunit}=="ctx") float NMDAtau2 = (112.5e-3)/2 // ctx avg for .25 NR2B and .75 NR2A. else echo "no other NMDA subunits defined in SynParamsCtx.g" end float N2Aratio=1.0 //NMDA to AMPA ratio of 1:1 is in middle of measured range for striatum float NMDAgmax = {AMPAgmax}*{N2Aratio} //0.94e-9 NR2A and B from (Moyner et al., 1994 figure 7) //0.47e-9 using 2.75:1 NMDA:AMPA (Ding 2008), which is extreme. float NMDAperCa = 0.2 // percent calcium influx Note: Divided by 2 in AddSynapticChannel for GHK case because of the enhanced driving potential: ohmic to GHK, reversal potentail from 0 to huge value float NMDAfactGHK = 55e-9//35e-9 //adjustment factor for GHK to calcium shell/pool //This is necessary because GHK reads in Gk from block and interprets it as permeability. this results in ridiculous current, restored to normal by factor of ~e-8 float NMDAdes = 0 //1 //desensitization factor, (depr_per_spike field of facsynchan) float NMDAdestau = 0 //200e-3 // desensitixation t (how fast des recovers) str NMDAname = {subunit} //for saving info on distal or proximal dendrites or massed and spaced. formula typeof dend, # of spines. //parameters for NMDA calcium interactions int NMDABufferMode = 0 // 1, connect both NMDA and AMPA calcium to Calcium_pool // 0, connect only NMDA currents to calcium_pool str bufferNMDA="Ca_pool_nmda" if ({calciumtype}==0) str NMDApool= {CalciumName}@"1" else str NMDApool={bufferNMDA} end