//genesis /*************************** MS Model, Version 9.1 ********************* **************************** CaL12channel.g ********************* Rebekah Evans updated 3/20/12 ****************************************************************************** ******************************************************************************/ function create_CaL12 str chanName = "CaL12_channel" str compPath = "/library" int c float Ek = 0.140 //(nernst calculated for 35degrees, [Cain] 50nM [Caout]2mM) //Ek is overwritten the the GHK object if it is used. float xmin = -0.1 float xmax = 0.05 int xdivs = 3000 float mPower = 1.0 //mh is an equally common form to m2h (tuckwell 2012) float hPower = 1.0 if (calciuminact == 1) float zpower = 1.0 else float zpower = 0 end float increment ={{xmax}-{xmin}}/{xdivs} echo "CaL12 increment:" {increment} "V" float x = -0.1 float surf = 0 float gMax = 0 float hTauCaL12 = 44.3e-3 float mTauCaL12 = 0.0 float mvHalfCaL12 = -8.9e-3 float mkCaL12 = -6.7e-3 float hvHalfCaL12 = -55e-3 float hkCaL12 = 8e-3 float hInfCaL12 = 0.0 float mInfCaL12 = 0.0 float theta = 0.0 float beta = 0.0 float beta_exp = 0.0 float mA = 0.0 float mB = 0.0 float qFactCaL12 = {qfactCa} pushe {compPath} create tabchannel {chanName} setfield {chanName} Ek {Ek} Xpower {mPower} Ypower {hPower} Zpower {zpower} call {chanName} TABCREATE X {xdivs} {xmin} {xmax} call {chanName} TABCREATE Y {xdivs} {xmin} {xmax} //fill in the voltage act and inact tables for(c = 0; c < {xdivs} + 1; c = c + 1) /************************ Begin CaL12_mTau *********************/ //mA = 0.0398e6*(vMemb + 8.124e-3)./(exp((vMemb + 8.124e-3)/9.005e-3) - 1); //mB = 0.99e3*exp(vMemb/31.4e-3); //mTauCaL12 = 1./(mA + mB) / qFactCaL12; //theta = 0.0398e6*{ {x} + 8.124e-3} //beta = {{x} + 8.124e-3}/9.005e-3 //beta_exp = {{exp {beta}} - 1.0} //mA = {{theta}/{beta_exp}} mA = {-110000.0 * {{x}+.00399}}/{-1.0 + {exp { {.00399 + {x} }/{-.0075}}}} //beta = {{x}/31.4e-3} //beta_exp = {exp {beta}} //mB = 0.99e3*{beta_exp} mB = {35500.0 * {{x}-.00399}}/{-1.0 + {exp { {-.00399 + {x} }/{.005}}}} mTauCaL12 = {1.0/{mA + mB}}/{qFactCaL12} setfield {chanName} X_A->table[{c}] {mTauCaL12} /************************ End CaL12_mTau ***********************/ /************************ Begin CaL12_mInf *********************/ // mInfCaL12 = 1./(1 + exp((vMemb - mvHalfCaL12)/mkCaL12)); //beta = {{x} - {mvHalfCaL12}}/{mkCaL12} //beta_exp = {exp {beta}} + 1.0 //mInfCaL12 = 1.0/{beta_exp} mInfCaL12 = {mA / {mA + mB}} setfield {chanName} X_B->table[{c}] {mInfCaL12} /************************ End CaL12_mInf ***********************/ /************************ Begin CaL12_hTau *********************/ // hTauCaL12 setfield {chanName} Y_A->table[{c}] {{hTauCaL12}/{qFactCaL12}} /************************ End CaL12_hTau ***********************/ /************************ Begin CaL12_hInf *********************/ // hInfCaL12 = 1./(1 + exp((vMemb - hvHalfCaL12)/hkCaL12)); beta = {{x} - {hvHalfCaL12}}/{hkCaL12} beta_exp = {exp {beta}} + 1.0 //0.17 has vdep inactivation, 0.83 does not inactivate hInfCaL12 = {0.17*{1.0/{beta_exp}} + 0.83} setfield {chanName} Y_B->table[{c}] {hInfCaL12} /************************ End CaL12_hInf ***********************/ x = x + increment end tweaktau {chanName} X tweaktau {chanName} Y //fill in the Z table with CDI values if (calciuminact == 1) addCDI {chanName} end addGHK {chanName} setfield {chanName} Gbar {gMax*surf} pope end