place the chemesis2.6.tgz file into your genesis-2.4 directory. I.e., when you downloaded and installed genesis-2.4, it created genesis-2.4/genesis after moving chemesis2.6.tgz into genesis-2.4, then ls genesis-2.4/ shows chemesis2.6.tgz genesis extract the files by typing: tar -xzf chemesis2.6.tgz then "ls genesis-2.4/" shows chan chemesis2.6.tgz chemesisREADME genesis Makefile then type "make" (though you might have to edit the Makefile if you changed the default linux installation in your genesis-2.4 Makefile) This will create and a few chemesis objects that did not get distributed with genesis2.4. The most important one is caplas_synchan, which implements a calcium dependent plasticity channel.