<?xml version="1.0" encoding="UTF-8"?>

<!-- ========================================================= -->

<!-- This model have been published in the following paper: 

Sasidharakurup H, Melethadathil N, Nair B, Diwakar S. "A Systems Model of Parkinson's Disease Using Biochemical Systems Theory", OMICS:A Journal of Integrative Biology 2017 21 8,454 -464.
Available at: http://online.liebertpub.com/doi/full/10.1089/omi.2017.0056 -->


<!-- Major pathways involving in Parkinson's disease such as alphasynuclein aggregation, dopamine synthesis, Lewy body formation, tau phosphorylation, parkin, and apoptosis were modeled 
using stochastic differential equations. Pathways were modeled and simulated using the biochemical pathway visualization program CellDesigner, a modeling tool for gene-regulatory and biochemical networks that support graphical notation and listing of symbols. -->

<!-- Last updated 10-January-2018
Developed by : Hemalatha Sasidharakurup & Dr. Shyam Diwakar    
Computational Neuroscience & Neurophysiology Lab, School of Biotechnology, Amrita University, India.
Email: shyam@amrita.edu, hemalathas@am.amrita.edu
www.amrita.edu/compneuro -->

<!-- ========================================================= -->




<sbml xmlns="http://www.sbml.org/sbml/level2/version4" level="2" version="4">
<model metaid="braatz_new" id="braatz_new">
<annotation/>

<listOfUnitDefinitions>

<unitDefinition metaid="substance" id="substance" name="substance">
<listOfUnits>
<unit metaid="CDMT00586" kind="mole"/>
</listOfUnits>
</unitDefinition>
<unitDefinition metaid="volume" id="volume" name="volume">
<listOfUnits>
<unit metaid="CDMT00587" kind="litre"/>
</listOfUnits>
</unitDefinition>
<unitDefinition metaid="area" id="area" name="area">
<listOfUnits>
<unit metaid="CDMT00588" kind="metre" exponent="2"/>
</listOfUnits>
</unitDefinition>
<unitDefinition metaid="length" id="length" name="length">
<listOfUnits>
<unit metaid="CDMT00589" kind="metre"/>
</listOfUnits>
</unitDefinition>
<unitDefinition metaid="time" id="time" name="time">
<listOfUnits>
<unit metaid="CDMT00590" kind="second"/>
</listOfUnits>
</unitDefinition>

</listOfUnitDefinitions>


<listOfCompartments>

<compartment metaid="default" id="default" size="1" units="volume"/>

</listOfCompartments>


<listOfSpecies>

<species metaid="s7" id="s7" name="glutathione expression" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s6" id="s6" name="glutathione" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s4" id="s4" name="dehydroascorbate cyt" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s5" id="s5" name="ascorbate" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s8" id="s8" name="glutathione gene" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s9" id="s9" name="DA into vesicle" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s10" id="s10" name="unused" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s14" id="s14" name="H2O2 degradation" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s21" id="s21" name="Ca2+ ER" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s43" id="s43" name="ATPase empty" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s45" id="s45" name="ryanodine emplty" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s48" id="s48" name="IP3 empty" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s50" id="s50" name="ER stress/UPR" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s66" id="s66" name="unknown" compartment="default" initialAmount="0">
<annotation/>
</species>
<species metaid="s51" id="s51" name="ROS ER" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s52" id="s52" name="Pael - R" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s54" id="s54" name="Ca2+ cyt" compartment="default" initialAmount="0">
<annotation/>
</species>
<species metaid="s55" id="s55" name="O2 cyt" compartment="default" initialAmount="0">
<annotation/>
</species>
<species metaid="s56" id="s56" name="H2O2 cyt" compartment="default" initialAmount="0">
<annotation/>
</species>
<species metaid="s63" id="s63" name="Ca2+/Na2+ transport empty " compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s64" id="s64" name="TRPC1 empty" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s65" id="s65" name="Ca2+ out" compartment="default" initialAmount="0">
<annotation/>
</species>
<species metaid="s67" id="s67" name="VDCC empty" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s70" id="s70" name="Parkin misfold" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s74" id="s74" name="Parkin" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s75" id="s75" name="ROS induced parkin misfold" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s40" id="s40" name="ROS" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s41" id="s41" name="ROS a" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s80" id="s80" name="O2- cyt" compartment="default" initialAmount="0">
<annotation/>
</species>
<species metaid="s81" id="s81" name="OH-" compartment="default" initialAmount="0">
<annotation/>
</species>
<species metaid="s82" id="s82" name="ONOO-" compartment="default" initialAmount="0">
<annotation/>
</species>
<species metaid="s83" id="s83" name="Lipid peroxidise formation" compartment="default" initialAmount="0">
<annotation/>
</species>
<species metaid="s84" id="s84" name="lipids" compartment="default" initialAmount="0">
<annotation/>
</species>
<species metaid="s85" id="s85" name="lipid peroxidise" compartment="default" initialAmount="0">
<annotation/>
</species>
<species metaid="s86" id="s86" name="Lewybody formation" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s87" id="s87" name="Cell death" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s88" id="s88" name="Tau P" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s89" id="s89" name="a synuclein aggregates cyt" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s90" id="s90" name="inflammation" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s91" id="s91" name="NF-kB (non canonical) nu" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s92" id="s92" name="Unknown" compartment="default" initialAmount="0">
<annotation/>
</species>
<species metaid="s93" id="s93" name="Lewibodies" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s94" id="s94" name="neurofibrillary tangles" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s95" id="s95" name="impeded axonal transport" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s98" id="s98" name="a synuclein" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s99" id="s99" name="nuclear transport empty a" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s117" id="s117" name="Tau" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s119" id="s119" name="insulin signaling" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s140" id="s140" name="dopamine out" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s141" id="s141" name="Na+" compartment="default" initialAmount="0">
<annotation/>
</species>
<species metaid="s142" id="s142" name="Dopamine cyt" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s143" id="s143" name="Dopamine reuptake" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s144" id="s144" name="DART RNA" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s145" id="s145" name="lipid peroxidation" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s146" id="s146" name="lipid peroxidise" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s147" id="s147" name="lipids" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s148" id="s148" name="O2- cyt" compartment="default" initialAmount="0">
<annotation/>
</species>
<species metaid="s161" id="s161" name="ROS nu" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s162" id="s162" name="SP1" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s163" id="s163" name="SP1 ac" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s167" id="s167" name="NRF-1 " compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s164" id="s164" name="NRF-1 expression" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s166" id="s166" name="NRF-1 gene" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s190" id="s190" name="Dopamine reuptake transporter" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s191" id="s191" name="DART gene" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s192" id="s192" name="NF-kB(non canonical to nu)" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s193" id="s193" name="NF-kB (noncanonical) Cyt Ub" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s211" id="s211" name="NF-kB (noncanonical)Cyt" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s212" id="s212" name="NF-kB (noncanonical)" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s224" id="s224" name="O2- Cyt" compartment="default" initialAmount="0">
<annotation/>
</species>
<species metaid="s225" id="s225" name="NO out" compartment="default" initialAmount="0">
<annotation/>
</species>
<species metaid="s226" id="s226" name="H2O2 Cyt" compartment="default" initialAmount="0">
<annotation/>
</species>
<species metaid="s227" id="s227" name="O2- degradation" compartment="default" initialAmount="0">
<annotation/>
</species>
<species metaid="s228" id="s228" name="H2O2 degradation" compartment="default" initialAmount="0">
<annotation/>
</species>
<species metaid="s229" id="s229" name="O2 Cyt" compartment="default" initialAmount="0">
<annotation/>
</species>
<species metaid="s230" id="s230" name="H2O2  degradation to OH-" compartment="default" initialAmount="0">
<annotation/>
</species>
<species metaid="s231" id="s231" name="H2O2m" compartment="default" initialAmount="0">
<annotation/>
</species>
<species metaid="s232" id="s232" name="Dopamine metabolism" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s233" id="s233" name="ONOO-" compartment="default" initialAmount="0">
<annotation/>
</species>
<species metaid="s234" id="s234" name="H2O Cyt" compartment="default" initialAmount="0">
<annotation/>
</species>
<species metaid="s235" id="s235" name="Ferrocytochrome C" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s236" id="s236" name="PIP2 " compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s237" id="s237" name="PIP2 " compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s238" id="s238" name="DOPAL" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s239" id="s239" name="NH2+" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s240" id="s240" name="Pael-R Ub" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s242" id="s242" name="UPS" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s245" id="s245" name="PARIS Ub" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s246" id="s246" name="Pael-R Ubiquitination" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s247" id="s247" name="PARIS" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s248" id="s248" name="PARIS Ubiquitination" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s258" id="s258" name="NO Cyt" compartment="default" initialAmount="0">
<annotation/>
</species>
<species metaid="s259" id="s259" name="NO a" compartment="default" initialAmount="0">
<annotation/>
</species>
<species metaid="s260" id="s260" name="NO m" compartment="default" initialAmount="0">
<annotation/>
</species>
<species metaid="s270" id="s270" name="DA quinones" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s274" id="s274" name="L-Dopa Synthesis" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s275" id="s275" name="L-Dopa" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s276" id="s276" name="tyrosine" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s277" id="s277" name="Dopamine Synthesis" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s314" id="s314" name="Necrosis" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s299" id="s299" name="Cytochrome c released" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s293" id="s293" name="Apoptosome" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s298" id="s298" name="Cytochrome c Cyt" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s295" id="s295" name="APAF-1" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s294" id="s294" name="dATP mt" compartment="default" initialAmount="0">
<annotation/>
</species>
<species metaid="s290" id="s290" name="Caspase 3" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s297" id="s297" name="Apoptosome formation" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s292" id="s292" name="Caspases" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s289" id="s289" name="Procaspase 3 " compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s291" id="s291" name="IAP" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s309" id="s309" name="CLPP-1 deactivated" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s312" id="s312" name="SMAC/DIABLO release from mitochondria" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s313" id="s313" name="SMAC/DIABLO mt" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s311" id="s311" name="SMAC/DIABLO Cyt" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s308" id="s308" name="SMAL/DIABLO Cyt" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s288" id="s288" name="Caspase 3 maturation" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s324" id="s324" name="PKCd catalytic Unit" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s183" id="s183" name="DNA Fragmentation" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s325" id="s325" name="ATP Depletion" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s326" id="s326" name="ONOO-" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s327" id="s327" name="Chromosome Condensation" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s328" id="s328" name="Apoptosis" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s329" id="s329" name="Cytochrome c release from mitochondria" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s330" id="s330" name="Cytochrome c mt" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s331" id="s331" name="Hsp27(active)" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s332" id="s332" name="PKCd Cleavage" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s333" id="s333" name="PKCd" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s334" id="s334" name="Caspase 9 maturation" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s335" id="s335" name="Procaspase 9" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s336" id="s336" name="Caspase 9" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s221" id="s221" name="mitochondrial protein genes mt" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s200" id="s200" name="JUN" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s201" id="s201" name="JUN" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s218" id="s218" name="Hsp70 activation" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s217" id="s217" name="tmTNFa a" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s184" id="s184" name="Hsp 70" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s180" id="s180" name="AIF" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s181" id="s181" name="AIF Nu" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s219" id="s219" name="PINK1 Cyt" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s182" id="s182" name="Chromosome condensation" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s337" id="s337" name="APAF-1 expression" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s338" id="s338" name="APAF-1 gene" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s339" id="s339" name="Hsp90(active)" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s340" id="s340" name="Hsp90 APAF inhibition complex" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s341" id="s341" name="Hsp70 APAF inhibition complex" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s342" id="s342" name="Hsp90" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s346" id="s346" name="Hsp70 gene" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s347" id="s347" name="Hsp70 expression" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s348" id="s348" name="Hsp70(active)" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s352" id="s352" name="Hsp27 activation" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s96" id="s96" name="Hsp27" compartment="default" initialAmount="0" charge="0">
<annotation/>
</species>
<species metaid="s44" id="s44" name="Ca2+ into ER complex" compartment="default" initialAmount="0">
<annotation/>
</species>
<species metaid="s46" id="s46" name="Ca2+ to ryanodine complex" compartment="default" initialAmount="0">
<annotation/>
</species>
<species metaid="s47" id="s47" name="ryanodine complex" compartment="default" initialAmount="0">
<annotation/>
</species>
<species metaid="s49" id="s49" name="IP3 complex" compartment="default" initialAmount="0">
<annotation/>
</species>
<species metaid="s60" id="s60" name="TRPC1 complex" compartment="default" initialAmount="0">
<annotation/>
</species>
<species metaid="s61" id="s61" name="VDCC complex" compartment="default" initialAmount="0">
<annotation/>
</species>
<species metaid="s62" id="s62" name="Na+/Ca2+ transport omplex" compartment="default" initialAmount="0">
<annotation/>
</species>
<species metaid="s69" id="s69" name="Ca2+ to VDCC complex" compartment="default" initialAmount="0">
<annotation/>
</species>
<species metaid="s97" id="s97" name="Tau P inhibition complex" compartment="default" initialAmount="0">
<annotation/>
</species>
<species metaid="s118" id="s118" name="insulin receptor complex" compartment="default" initialAmount="0">
<annotation/>
</species>
<species metaid="s138" id="s138" name="dopamine to dopamine reuptake transporter complex" compartment="default" initialAmount="0">
<annotation/>
</species>
<species metaid="s139" id="s139" name="dopamine reuptake complex" compartment="default" initialAmount="0">
<annotation/>
</species>
<species metaid="s223" id="s223" name="VDAC Complex" compartment="default" initialAmount="0">
<annotation/>
</species>
<species metaid="s241" id="s241" name="Pael-R degradation complex" compartment="default" initialAmount="0">
<annotation/>
</species>
<species metaid="s243" id="s243" name="Parkin degradation complex formation" compartment="default" initialAmount="0">
<annotation/>
</species>
<species metaid="s244" id="s244" name="PARIS degradation Complex" compartment="default" initialAmount="0">
<annotation/>
</species>
<species metaid="s296" id="s296" name="Caspase 9 inhibition complex" compartment="default" initialAmount="0">
<annotation/>
</species>
<species metaid="s307" id="s307" name="IAP inhibition complex" compartment="default" initialAmount="0">
<annotation/>
</species>
<species metaid="s310" id="s310" name="Caspase 3 inhibition complex" compartment="default" initialAmount="0">
<annotation/>
</species>
<species metaid="s316" id="s316" name="Cyt c Inhibition Complex" compartment="default" initialAmount="0">
<annotation/>
</species>
<species metaid="s220" id="s220" name="Hsp70 APAF inhibition complex" compartment="default" initialAmount="0">
<annotation/>
</species>
<species metaid="s222" id="s222" name="AIF inhibition complex" compartment="default" initialAmount="0">
<annotation/>
</species>
<species metaid="s202" id="s202" name="JNK inhibition complex" compartment="default" initialAmount="0">
<annotation/>
</species>

</listOfSpecies>


<listOfReactions>

<reaction metaid="re61" id="re2" name="re2" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00005" species="s4"/>
<speciesReference metaid="CDMT00006" species="s6"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00007" species="s5"/>
</listOfProducts>
</reaction>
<reaction metaid="re7" id="re3" name="re3" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00008" species="s7"/>
<speciesReference metaid="CDMT00009" species="s8"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00010" species="s6"/>
</listOfProducts>
</reaction>
<reaction metaid="re8" id="re4" name="re4" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00011" species="s9"/>
<speciesReference metaid="CDMT00012" species="s10"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00013" species="s6"/>
</listOfProducts>
</reaction>
<reaction metaid="re23" id="re7" name="re7" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00020" species="s43"/>
<speciesReference metaid="CDMT00021" species="s54"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00022" species="s44"/>
</listOfProducts>
</reaction>
<reaction metaid="re24" id="re8" name="re8" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00023" species="s44"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00024" species="s21"/>
</listOfProducts>
</reaction>
<reaction metaid="CDMT00057" id="re9" name="re9" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00025" species="s45"/>
<speciesReference metaid="CDMT00026" species="s46"/>
<speciesReference metaid="CDMT00027" species="s21"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00028" species="s47"/>
</listOfProducts>
</reaction>
<reaction metaid="re27" id="re10" name="re10" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00029" species="s48"/>
<speciesReference metaid="CDMT00030" species="s21"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00031" species="s49"/>
</listOfProducts>
</reaction>
<reaction metaid="re28" id="re11" name="re11" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00032" species="s21"/>
<speciesReference metaid="CDMT00033" species="s50"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00034" species="s66"/>
</listOfProducts>
</reaction>
<reaction metaid="re29" id="re12" name="re12" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00035" species="s51"/>
<speciesReference metaid="CDMT00036" species="s52"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00037" species="s50"/>
</listOfProducts>
</reaction>
<reaction metaid="re31" id="re13" name="re13" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00038" species="s49"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00039" species="s54"/>
</listOfProducts>
</reaction>
<reaction metaid="re32" id="re14" name="re14" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00040" species="s6"/>
<speciesReference metaid="CDMT00041" species="s14"/>
<speciesReference metaid="CDMT00042" species="s56"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00043" species="s55"/>
</listOfProducts>
</reaction>
<reaction metaid="re36" id="re15" name="re15" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00044" species="s47"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00045" species="s54"/>
</listOfProducts>
</reaction>
<reaction metaid="re37" id="re16" name="re16" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00046" species="s60"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00047" species="s54"/>
</listOfProducts>
</reaction>
<reaction metaid="re39" id="re17" name="re17" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00048" species="s62"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00049" species="s54"/>
</listOfProducts>
</reaction>
<reaction metaid="re40" id="re18" name="re18" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00050" species="s63"/>
<speciesReference metaid="CDMT00051" species="s54"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00052" species="s66"/>
</listOfProducts>
</reaction>
<reaction metaid="re41" id="re19" name="re19" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00053" species="s64"/>
<speciesReference metaid="CDMT00054" species="s65"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00055" species="s60"/>
</listOfProducts>
</reaction>
<reaction metaid="re42" id="re20" name="re20" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00056" species="s67"/>
<speciesReference metaid="CDMT00058" species="s65"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00059" species="s69"/>
</listOfProducts>
</reaction>
<reaction metaid="re43" id="re21" name="re21" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00060" species="s69"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00061" species="s61"/>
</listOfProducts>
</reaction>
<reaction metaid="re44" id="re22" name="re22" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00062" species="s61"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00063" species="s54"/>
</listOfProducts>
</reaction>
<reaction metaid="re45" id="re23" name="re23" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00064" species="s41"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00065" species="s40"/>
</listOfProducts>
</reaction>
<reaction metaid="re38" id="re24" name="re24" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00066" species="s40"/>
<speciesReference metaid="CDMT00067" species="s75"/>
<speciesReference metaid="CDMT00068" species="s74"/>
<speciesReference metaid="CDMT00069" species="s80"/>
<speciesReference metaid="CDMT00070" species="s81"/>
<speciesReference metaid="CDMT00071" species="s82"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00072" species="s70"/>
</listOfProducts>
</reaction>
<reaction metaid="re48" id="re25" name="re25" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00073" species="s40"/>
<speciesReference metaid="CDMT00074" species="s82"/>
<speciesReference metaid="CDMT00075" species="s83"/>
<speciesReference metaid="CDMT00076" species="s84"/>
<speciesReference metaid="CDMT00077" species="s80"/>
<speciesReference metaid="CDMT00078" species="s56"/>
<speciesReference metaid="CDMT00079" species="s81"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00080" species="s85"/>
</listOfProducts>
</reaction>
<reaction metaid="re51" id="re26" name="re26" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00081" species="s70"/>
<speciesReference metaid="CDMT00082" species="s86"/>
<speciesReference metaid="CDMT00083" species="s98"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00084" species="s87"/>
</listOfProducts>
</reaction>
<reaction metaid="re52" id="re27" name="re27" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00085" species="s86"/>
<speciesReference metaid="CDMT00086" species="s89"/>
<speciesReference metaid="CDMT00087" species="s88"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00088" species="s87"/>
</listOfProducts>
</reaction>
<reaction metaid="re56" id="re28" name="re28" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00089" species="s86"/>
<speciesReference metaid="CDMT00090" species="s52"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00091" species="s87"/>
</listOfProducts>
</reaction>
<reaction metaid="re57" id="re29" name="re29" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00092" species="s90"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00093" species="s87"/>
</listOfProducts>
</reaction>
<reaction metaid="re58" id="re30" name="re30" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00094" species="s87"/>
<speciesReference metaid="CDMT00095" species="s91"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00096" species="s92"/>
</listOfProducts>
</reaction>
<reaction metaid="re59" id="re31" name="re31" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00097" species="s93"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00098" species="s87"/>
</listOfProducts>
</reaction>
<reaction metaid="re60" id="re32" name="re32" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00099" species="s94"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00100" species="s91"/>
</listOfProducts>
</reaction>
<reaction metaid="re33" id="re33" name="re33" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00101" species="s86"/>
<speciesReference metaid="CDMT00102" species="s89"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00103" species="s93"/>
</listOfProducts>
</reaction>
<reaction metaid="re62" id="re34" name="re34" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00104" species="s86"/>
<speciesReference metaid="CDMT00105" species="s88"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00106" species="s93"/>
</listOfProducts>
</reaction>
<reaction metaid="re63" id="re35" name="re35" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00107" species="s86"/>
<speciesReference metaid="CDMT00108" species="s52"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00109" species="s93"/>
</listOfProducts>
</reaction>
<reaction metaid="re64" id="re36" name="re36" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00110" species="s88"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00111" species="s94"/>
</listOfProducts>
</reaction>
<reaction metaid="re65" id="re37" name="re37" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00112" species="s88"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00113" species="s95"/>
</listOfProducts>
</reaction>
<reaction metaid="re67" id="re38" name="re38" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00114" species="s89"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00115" species="s88"/>
</listOfProducts>
</reaction>
<reaction metaid="re68" id="re39" name="re39" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00116" species="s52"/>
<speciesReference metaid="CDMT00117" species="s88"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00118" species="s92"/>
</listOfProducts>
</reaction>
<reaction metaid="re71" id="re40" name="re40" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00119" species="s86"/>
<speciesReference metaid="CDMT00120" species="s88"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00121" species="s87"/>
</listOfProducts>
</reaction>
<reaction metaid="re72" id="re41" name="re41" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00122" species="s88"/>
<speciesReference metaid="CDMT00123" species="s331"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00124" species="s97"/>
</listOfProducts>
</reaction>
<reaction metaid="re73" id="re42" name="re42" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00125" species="s98"/>
<speciesReference metaid="CDMT00126" species="s95"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00127" species="s89"/>
</listOfProducts>
</reaction>
<reaction metaid="re74" id="re43" name="re43" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00128" species="s98"/>
<speciesReference metaid="CDMT00129" species="s99"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00130" species="s89"/>
</listOfProducts>
</reaction>
<reaction metaid="re75" id="re44" name="re44" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00131" species="s89"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00132" species="s66"/>
</listOfProducts>
</reaction>
<reaction metaid="re86" id="re53" name="re53" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00152" species="s117"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00153" species="s88"/>
</listOfProducts>
</reaction>
<reaction metaid="re87" id="re54" name="re54" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00154" species="s95"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00155" species="s118"/>
</listOfProducts>
</reaction>
<reaction metaid="re88" id="re55" name="re55" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00156" species="s88"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00157" species="s118"/>
</listOfProducts>
</reaction>
<reaction metaid="re89" id="re56" name="re56" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00158" species="s97"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00159" species="s118"/>
</listOfProducts>
</reaction>
<reaction metaid="re90" id="re57" name="re57" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00160" species="s119"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00161" species="s118"/>
</listOfProducts>
</reaction>
<reaction metaid="re99" id="re66" name="re66" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00185" species="s139"/>
<speciesReference metaid="CDMT00186" species="s140"/>
<speciesReference metaid="CDMT00187" species="s141"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00188" species="s138"/>
</listOfProducts>
</reaction>
<reaction metaid="re101" id="re67" name="re67" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00189" species="s138"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00190" species="s143"/>
</listOfProducts>
</reaction>
<reaction metaid="re102" id="re68" name="re68" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00191" species="s143"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00192" species="s142"/>
</listOfProducts>
</reaction>
<reaction metaid="re104" id="re69" name="re69" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00193" species="s147"/>
<speciesReference metaid="CDMT00194" species="s40"/>
<speciesReference metaid="CDMT00195" species="s56"/>
<speciesReference metaid="CDMT00196" species="s82"/>
<speciesReference metaid="CDMT00197" species="s148"/>
<speciesReference metaid="CDMT00198" species="s81"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00199" species="s145"/>
</listOfProducts>
</reaction>
<reaction metaid="re105" id="re70" name="re70" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00200" species="s145"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00201" species="s146"/>
</listOfProducts>
</reaction>
<reaction metaid="re114" id="re78" name="re78" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00219" species="s40"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00220" species="s161"/>
</listOfProducts>
</reaction>
<reaction metaid="re115" id="re79" name="re79" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00221" species="s161"/>
<speciesReference metaid="CDMT00222" species="s162"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00223" species="s163"/>
</listOfProducts>
</reaction>
<reaction metaid="re116" id="re91" name="re91" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00247" species="s166"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00248" species="s164"/>
</listOfProducts>
</reaction>
<reaction metaid="re117" id="re92" name="re92" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00249" species="s164"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00250" species="s167"/>
</listOfProducts>
</reaction>
<reaction metaid="re135" id="re93" name="re93" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00251" species="s191"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00252" species="s144"/>
</listOfProducts>
</reaction>
<reaction metaid="re136" id="re94" name="re94" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00253" species="s190"/>
<speciesReference metaid="CDMT00254" species="s144"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00255" species="s139"/>
</listOfProducts>
</reaction>
<reaction metaid="re137" id="re95" name="re95" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00256" species="s144"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00257" species="s166"/>
</listOfProducts>
</reaction>
<reaction metaid="re138" id="re96" name="re96" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00258" species="s192"/>
<speciesReference metaid="CDMT00259" species="s193"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00260" species="s91"/>
</listOfProducts>
</reaction>
<reaction metaid="re154" id="re106" name="re106" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00280" species="s211"/>
<speciesReference metaid="CDMT00281" species="s212"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00282" species="s193"/>
</listOfProducts>
</reaction>
<reaction metaid="re163" id="re109" name="re109" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00289" species="s223"/>
<speciesReference metaid="CDMT00290" species="s142"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00291" species="s224"/>
</listOfProducts>
</reaction>
<reaction metaid="re164" id="re110" name="re110" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00292" species="s224"/>
<speciesReference metaid="CDMT00293" species="s225"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00294" species="s92"/>
<speciesReference metaid="CDMT00295" species="s233"/>
</listOfProducts>
</reaction>
<reaction metaid="re165" id="re111" name="re111" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00296" species="s224"/>
<speciesReference metaid="CDMT00297" species="s227"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00298" species="s226"/>
</listOfProducts>
</reaction>
<reaction metaid="re166" id="re112" name="re112" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00299" species="s226"/>
<speciesReference metaid="CDMT00300" species="s228"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00301" species="s229"/>
</listOfProducts>
</reaction>
<reaction metaid="re167" id="re113" name="re113" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00302" species="s226"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00303" species="s230"/>
</listOfProducts>
</reaction>
<reaction metaid="re168" id="re114" name="re114" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00304" species="s230"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00305" species="s81"/>
</listOfProducts>
</reaction>
<reaction metaid="re169" id="re115" name="re115" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00306" species="s231"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00307" species="s226"/>
</listOfProducts>
</reaction>
<reaction metaid="re170" id="re116" name="re116" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00308" species="s142"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00309" species="s226"/>
</listOfProducts>
</reaction>
<reaction metaid="re171" id="re117" name="re117" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00310" species="s232"/>
<speciesReference metaid="CDMT00311" species="s229"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00312" species="s142"/>
<speciesReference metaid="CDMT00313" species="s238"/>
<speciesReference metaid="CDMT00314" species="s239"/>
</listOfProducts>
</reaction>
<reaction metaid="re172" id="re118" name="re118" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00315" species="s233"/>
<speciesReference metaid="CDMT00316" species="s92"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00317" species="s81"/>
</listOfProducts>
</reaction>
<reaction metaid="re173" id="re119" name="re119" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00318" species="s81"/>
<speciesReference metaid="CDMT00319" species="s92"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00320" species="s234"/>
</listOfProducts>
</reaction>
<reaction metaid="re174" id="re120" name="re120" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00321" species="s236"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00322" species="s237"/>
</listOfProducts>
</reaction>
<reaction metaid="re175" id="re121" name="re121" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00323" species="s235"/>
<speciesReference metaid="CDMT00324" species="s237"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00325" species="s234"/>
</listOfProducts>
</reaction>
<reaction metaid="re176" id="re122" name="re122" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00326" species="s240"/>
<speciesReference metaid="CDMT00327" species="s242"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00328" species="s241"/>
</listOfProducts>
</reaction>
<reaction metaid="re177" id="re123" name="re123" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00329" species="s241"/>
<speciesReference metaid="CDMT00330" species="s74"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00331" species="s243"/>
</listOfProducts>
</reaction>
<reaction metaid="re178" id="re124" name="re124" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00332" species="s245"/>
<speciesReference metaid="CDMT00333" species="s242"/>
<speciesReference metaid="CDMT00334" species="s240"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00335" species="s244"/>
</listOfProducts>
</reaction>
<reaction metaid="re179" id="re125" name="re125" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00336" species="s246"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00337" species="s247"/>
</listOfProducts>
</reaction>
<reaction metaid="re180" id="re126" name="re126" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00338" species="s247"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00339" species="s240"/>
</listOfProducts>
</reaction>
<reaction metaid="re181" id="re127" name="re127" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00340" species="s248"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00341" species="s247"/>
</listOfProducts>
</reaction>
<reaction metaid="re182" id="re128" name="re128" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00342" species="s247"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00343" species="s245"/>
</listOfProducts>
</reaction>
<reaction metaid="re189" id="re134" name="re134" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00357" species="s225"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00358" species="s258"/>
</listOfProducts>
</reaction>
<reaction metaid="re190" id="re135" name="re135" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00359" species="s258"/>
<speciesReference metaid="CDMT00360" species="s229"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00361" species="s233"/>
</listOfProducts>
</reaction>
<reaction metaid="re191" id="re136" name="re136" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00362" species="s259"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00363" species="s260"/>
</listOfProducts>
</reaction>
<reaction metaid="re192" id="re137" name="re137" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00364" species="s260"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00365" species="s225"/>
</listOfProducts>
</reaction>
<reaction metaid="re199" id="re144" name="re144" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00379" species="s142"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00380" species="s270"/>
</listOfProducts>
</reaction>
<reaction metaid="re204" id="re147" name="re147" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00385" species="s274"/>
<speciesReference metaid="CDMT00386" species="s276"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00387" species="s275"/>
</listOfProducts>
</reaction>
<reaction metaid="re205" id="re148" name="re148" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00388" species="s275"/>
<speciesReference metaid="CDMT00389" species="s277"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00390" species="s142"/>
</listOfProducts>
</reaction>
<reaction metaid="re248" id="re153" name="re153" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00400" species="s226"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00401" species="s314"/>
</listOfProducts>
</reaction>
<reaction metaid="re216" id="re154" name="re154" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00402" species="s288"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00403" species="s289"/>
</listOfProducts>
</reaction>
<reaction metaid="re217" id="re155" name="re155" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00404" species="s289"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00405" species="s290"/>
</listOfProducts>
</reaction>
<reaction metaid="re218" id="re156" name="re156" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00406" species="s290"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00407" species="s291"/>
<speciesReference metaid="CDMT00408" species="s292"/>
</listOfProducts>
</reaction>
<reaction metaid="re226" id="re157" name="re157" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00409" species="s290"/>
<speciesReference metaid="CDMT00410" species="s294"/>
<speciesReference metaid="CDMT00411" species="s295"/>
<speciesReference metaid="CDMT00412" species="s298"/>
<speciesReference metaid="CDMT00413" species="s296"/>
<speciesReference metaid="CDMT00414" species="s297"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00415" species="s293"/>
</listOfProducts>
</reaction>
<reaction metaid="re227" id="re158" name="re158" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00416" species="s299"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00417" species="s298"/>
</listOfProducts>
</reaction>
<reaction metaid="re234" id="re159" name="re159" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00418" species="s291"/>
<speciesReference metaid="CDMT00419" species="s308"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00420" species="s307"/>
</listOfProducts>
</reaction>
<reaction metaid="re235" id="re160" name="re160" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00421" species="s291"/>
<speciesReference metaid="CDMT00422" species="s309"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00423" species="s296"/>
</listOfProducts>
</reaction>
<reaction metaid="re236" id="re161" name="re161" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00424" species="s291"/>
<speciesReference metaid="CDMT00425" species="s290"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00426" species="s310"/>
</listOfProducts>
</reaction>
<reaction metaid="re243" id="re162" name="re162" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00427" species="s312"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00428" species="s313"/>
</listOfProducts>
</reaction>
<reaction metaid="re244" id="re163" name="re163" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00429" species="s313"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00430" species="s311"/>
</listOfProducts>
</reaction>
<reaction metaid="re246" id="re164" name="re164" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00431" species="s291"/>
<speciesReference metaid="CDMT00432" species="s311"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00433" species="s307"/>
</listOfProducts>
</reaction>
<reaction metaid="re267" id="re171" name="re171" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00449" species="s316"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00450" species="s298"/>
</listOfProducts>
</reaction>
<reaction metaid="re273" id="re172" name="re172" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00451" species="s293"/>
<speciesReference metaid="CDMT00452" species="s324"/>
<speciesReference metaid="CDMT00453" species="s183"/>
<speciesReference metaid="CDMT00454" species="s327"/>
<speciesReference metaid="CDMT00455" species="s325"/>
<speciesReference metaid="CDMT00456" species="s326"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00457" species="s328"/>
</listOfProducts>
</reaction>
<reaction metaid="re276" id="re173" name="re173" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00458" species="s330"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00459" species="s329"/>
</listOfProducts>
</reaction>
<reaction metaid="re277" id="re174" name="re174" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00460" species="s329"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00461" species="s299"/>
</listOfProducts>
</reaction>
<reaction metaid="re278" id="re175" name="re175" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00462" species="s331"/>
<speciesReference metaid="CDMT00463" species="s299"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00464" species="s316"/>
</listOfProducts>
</reaction>
<reaction metaid="re279" id="re176" name="re176" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00465" species="s332"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00466" species="s333"/>
</listOfProducts>
</reaction>
<reaction metaid="re280" id="re177" name="re177" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00467" species="s333"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00468" species="s324"/>
</listOfProducts>
</reaction>
<reaction metaid="re281" id="re178" name="re178" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00469" species="s335"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00470" species="s334"/>
</listOfProducts>
</reaction>
<reaction metaid="re282" id="re179" name="re179" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00471" species="s334"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00472" species="s336"/>
</listOfProducts>
</reaction>
<reaction metaid="re283" id="re180" name="re180" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00473" species="s336"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00474" species="s293"/>
</listOfProducts>
</reaction>
<reaction metaid="re284" id="re181" name="re181" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00475" species="s291"/>
<speciesReference metaid="CDMT00476" species="s336"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00477" species="s92"/>
</listOfProducts>
</reaction>
<reaction metaid="re127" id="re182" name="re182" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00478" species="s180"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00479" species="s181"/>
</listOfProducts>
</reaction>
<reaction metaid="re128" id="re183" name="re183" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00480" species="s181"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00481" species="s182"/>
</listOfProducts>
</reaction>
<reaction metaid="re129" id="re184" name="re184" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00482" species="s181"/>
<speciesReference metaid="CDMT00483" species="s184"/>
<speciesReference metaid="CDMT00484" species="s180"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00485" species="s183"/>
</listOfProducts>
</reaction>
<reaction metaid="re145" id="re185" name="re185" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00486" species="s200"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00487" species="s201"/>
</listOfProducts>
</reaction>
<reaction metaid="re147" id="re186" name="re186" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00488" species="s201"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00489" species="s184"/>
</listOfProducts>
</reaction>
<reaction metaid="re148" id="re187" name="re187" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00490" species="s184"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00491" species="s202"/>
</listOfProducts>
</reaction>
<reaction metaid="re157" id="re188" name="re188" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00492" species="s217"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00493" species="s218"/>
</listOfProducts>
</reaction>
<reaction metaid="re158" id="re189" name="re189" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00494" species="s218"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00495" species="s184"/>
</listOfProducts>
</reaction>
<reaction metaid="re159" id="re190" name="re190" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00496" species="s180"/>
<speciesReference metaid="CDMT00497" species="s184"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00498" species="s219"/>
</listOfProducts>
</reaction>
<reaction metaid="re160" id="re191" name="re191" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00499" species="s184"/>
<speciesReference metaid="CDMT00500" species="s221"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00501" species="s220"/>
</listOfProducts>
</reaction>
<reaction metaid="re161" id="re192" name="re192" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00502" species="s180"/>
<speciesReference metaid="CDMT00503" species="s184"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00504" species="s222"/>
</listOfProducts>
</reaction>
<reaction metaid="re301" id="re198" name="re198" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00515" species="s338"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00516" species="s337"/>
</listOfProducts>
</reaction>
<reaction metaid="re302" id="re199" name="re199" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00517" species="s337"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00518" species="s295"/>
</listOfProducts>
</reaction>
<reaction metaid="re303" id="re200" name="re200" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00519" species="s339"/>
<speciesReference metaid="CDMT00520" species="s295"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00521" species="s340"/>
</listOfProducts>
</reaction>
<reaction metaid="re304" id="re201" name="re201" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00522" species="s348"/>
<speciesReference metaid="CDMT00523" species="s295"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00524" species="s341"/>
</listOfProducts>
</reaction>
<reaction metaid="re305" id="re202" name="re202" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00525" species="s342"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00526" species="s339"/>
</listOfProducts>
</reaction>
<reaction metaid="re308" id="re205" name="re205" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00531" species="s346"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00532" species="s347"/>
</listOfProducts>
</reaction>
<reaction metaid="re309" id="re206" name="re206" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00533" species="s347"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00534" species="s218"/>
</listOfProducts>
</reaction>
<reaction metaid="re310" id="re207" name="re207" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00535" species="s184"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00536" species="s348"/>
</listOfProducts>
</reaction>
<reaction metaid="re314" id="re211" name="re211" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00543" species="s352"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00544" species="s96"/>
</listOfProducts>
</reaction>
<reaction metaid="re315" id="re212" name="re212" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00545" species="s96"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00546" species="s331"/>
</listOfProducts>
</reaction>
</listOfReactions>
</model>
</sbml>