/* Created by Language version: 7.7.0 */
/* NOT VECTORIZED */
#define NRN_VECTORIZED 0
#include <stdio.h>
#include <stdlib.h>
#include <math.h>
#include "scoplib_ansi.h"
#undef PI
#define nil 0
#include "md1redef.h"
#include "section.h"
#include "nrniv_mf.h"
#include "md2redef.h"
#if METHOD3
extern int _method3;
#endif
#if !NRNGPU
#undef exp
#define exp hoc_Exp
extern double hoc_Exp(double);
#endif
#define nrn_init _nrn_init__tanhSyn
#define _nrn_initial _nrn_initial__tanhSyn
#define nrn_cur _nrn_cur__tanhSyn
#define _nrn_current _nrn_current__tanhSyn
#define nrn_jacob _nrn_jacob__tanhSyn
#define nrn_state _nrn_state__tanhSyn
#define _net_receive _net_receive__tanhSyn
#define state state__tanhSyn
#define _threadargscomma_ /**/
#define _threadargsprotocomma_ /**/
#define _threadargs_ /**/
#define _threadargsproto_ /**/
/*SUPPRESS 761*/
/*SUPPRESS 762*/
/*SUPPRESS 763*/
/*SUPPRESS 765*/
extern double *getarg();
static double *_p; static Datum *_ppvar;
#define t nrn_threads->_t
#define dt nrn_threads->_dt
#define e _p[0]
#define alpha _p[1]
#define tau _p[2]
#define noise _p[3]
#define g _p[4]
#define rparam _p[5]
#define voff _p[6]
#define i _p[7]
#define s _p[8]
#define Ds _p[9]
#define _g _p[10]
#define _nd_area *_ppvar[0]._pval
#define vpre *_ppvar[2]._pval
#define _p_vpre _ppvar[2]._pval
#if MAC
#if !defined(v)
#define v _mlhv
#endif
#if !defined(h)
#define h _mlhh
#endif
#endif
#if defined(__cplusplus)
extern "C" {
#endif
static int hoc_nrnpointerindex = 2;
/* external NEURON variables */
/* declaration of user functions */
static int _mechtype;
extern void _nrn_cacheloop_reg(int, int);
extern void hoc_register_prop_size(int, int, int);
extern void hoc_register_limits(int, HocParmLimits*);
extern void hoc_register_units(int, HocParmUnits*);
extern void nrn_promote(Prop*, int, int);
extern Memb_func* memb_func;
#define NMODL_TEXT 1
#if NMODL_TEXT
static const char* nmodl_file_text;
static const char* nmodl_filename;
extern void hoc_reg_nmodl_text(int, const char*);
extern void hoc_reg_nmodl_filename(int, const char*);
#endif
extern Prop* nrn_point_prop_;
static int _pointtype;
static void* _hoc_create_pnt(_ho) Object* _ho; { void* create_point_process();
return create_point_process(_pointtype, _ho);
}
static void _hoc_destroy_pnt();
static double _hoc_loc_pnt(_vptr) void* _vptr; {double loc_point_process();
return loc_point_process(_pointtype, _vptr);
}
static double _hoc_has_loc(_vptr) void* _vptr; {double has_loc_point();
return has_loc_point(_vptr);
}
static double _hoc_get_loc_pnt(_vptr)void* _vptr; {
double get_loc_point_process(); return (get_loc_point_process(_vptr));
}
extern void _nrn_setdata_reg(int, void(*)(Prop*));
static void _setdata(Prop* _prop) {
_p = _prop->param; _ppvar = _prop->dparam;
}
static void _hoc_setdata(void* _vptr) { Prop* _prop;
_prop = ((Point_process*)_vptr)->_prop;
_setdata(_prop);
}
/* connect user functions to hoc names */
static VoidFunc hoc_intfunc[] = {
0,0
};
static Member_func _member_func[] = {
"loc", _hoc_loc_pnt,
"has_loc", _hoc_has_loc,
"get_loc", _hoc_get_loc_pnt,
0, 0
};
/* declare global and static user variables */
/* some parameters have upper and lower limits */
static HocParmLimits _hoc_parm_limits[] = {
"tau", 1e-009, 1e+009,
0,0,0
};
static HocParmUnits _hoc_parm_units[] = {
"e", "mV",
"tau", "ms",
"g", "uS",
"voff", "mV",
"i", "nA",
"vpre", "mV",
0,0
};
static double delta_t = 0.01;
static double s0 = 0;
static double v = 0;
/* connect global user variables to hoc */
static DoubScal hoc_scdoub[] = {
0,0
};
static DoubVec hoc_vdoub[] = {
0,0,0
};
static double _sav_indep;
static void nrn_alloc(Prop*);
static void nrn_init(_NrnThread*, _Memb_list*, int);
static void nrn_state(_NrnThread*, _Memb_list*, int);
static void nrn_cur(_NrnThread*, _Memb_list*, int);
static void nrn_jacob(_NrnThread*, _Memb_list*, int);
static void _hoc_destroy_pnt(_vptr) void* _vptr; {
destroy_point_process(_vptr);
}
static int _ode_count(int);
static void _ode_map(int, double**, double**, double*, Datum*, double*, int);
static void _ode_spec(_NrnThread*, _Memb_list*, int);
static void _ode_matsol(_NrnThread*, _Memb_list*, int);
#define _cvode_ieq _ppvar[3]._i
static void _ode_matsol_instance1(_threadargsproto_);
/* connect range variables in _p that hoc is supposed to know about */
static const char *_mechanism[] = {
"7.7.0",
"tanhSyn",
"e",
"alpha",
"tau",
"noise",
"g",
"rparam",
"voff",
0,
"i",
0,
"s",
0,
"vpre",
0};
extern Prop* need_memb(Symbol*);
static void nrn_alloc(Prop* _prop) {
Prop *prop_ion;
double *_p; Datum *_ppvar;
if (nrn_point_prop_) {
_prop->_alloc_seq = nrn_point_prop_->_alloc_seq;
_p = nrn_point_prop_->param;
_ppvar = nrn_point_prop_->dparam;
}else{
_p = nrn_prop_data_alloc(_mechtype, 11, _prop);
/*initialize range parameters*/
e = 0;
alpha = 0.55;
tau = 5.26;
noise = 0;
g = 0.00027;
rparam = 4;
voff = 0;
}
_prop->param = _p;
_prop->param_size = 11;
if (!nrn_point_prop_) {
_ppvar = nrn_prop_datum_alloc(_mechtype, 4, _prop);
}
_prop->dparam = _ppvar;
/*connect ionic variables to this model*/
}
static void _initlists();
/* some states have an absolute tolerance */
static Symbol** _atollist;
static HocStateTolerance _hoc_state_tol[] = {
0,0
};
extern Symbol* hoc_lookup(const char*);
extern void _nrn_thread_reg(int, int, void(*)(Datum*));
extern void _nrn_thread_table_reg(int, void(*)(double*, Datum*, Datum*, _NrnThread*, int));
extern void hoc_register_tolerance(int, HocStateTolerance*, Symbol***);
extern void _cvode_abstol( Symbol**, double*, int);
void _noisytanhsyn_reg() {
int _vectorized = 0;
_initlists();
_pointtype = point_register_mech(_mechanism,
nrn_alloc,nrn_cur, nrn_jacob, nrn_state, nrn_init,
hoc_nrnpointerindex, 0,
_hoc_create_pnt, _hoc_destroy_pnt, _member_func);
_mechtype = nrn_get_mechtype(_mechanism[1]);
_nrn_setdata_reg(_mechtype, _setdata);
#if NMODL_TEXT
hoc_reg_nmodl_text(_mechtype, nmodl_file_text);
hoc_reg_nmodl_filename(_mechtype, nmodl_filename);
#endif
hoc_register_prop_size(_mechtype, 11, 4);
hoc_register_dparam_semantics(_mechtype, 0, "area");
hoc_register_dparam_semantics(_mechtype, 1, "pntproc");
hoc_register_dparam_semantics(_mechtype, 2, "pointer");
hoc_register_dparam_semantics(_mechtype, 3, "cvodeieq");
hoc_register_cvode(_mechtype, _ode_count, _ode_map, _ode_spec, _ode_matsol);
hoc_register_tolerance(_mechtype, _hoc_state_tol, &_atollist);
hoc_register_var(hoc_scdoub, hoc_vdoub, hoc_intfunc);
ivoc_help("help ?1 tanhSyn D:/Projects/SchreglmannEtAl2020/CCTC_model/modfiles/noisytanhsyn.mod\n");
hoc_register_limits(_mechtype, _hoc_parm_limits);
hoc_register_units(_mechtype, _hoc_parm_units);
}
static int _reset;
static char *modelname = "Continuous and instantaneous tanh-type synaptic transmission mechanism";
static int error;
static int _ninits = 0;
static int _match_recurse=1;
static void _modl_cleanup(){ _match_recurse=1;}
static int _ode_spec1(_threadargsproto_);
/*static int _ode_matsol1(_threadargsproto_);*/
static int _slist1[1], _dlist1[1];
static int state(_threadargsproto_);
/*CVODE*/
static int _ode_spec1 () {_reset=0;
{
Ds = alpha * ( 1.0 + tanh ( vpre - voff / rparam ) ) * ( 1.0 - s ) - s / tau + noise ;
}
return _reset;
}
static int _ode_matsol1 () {
Ds = Ds / (1. - dt*( ( alpha * ( 1.0 + tanh ( vpre - voff / rparam ) ) )*( ( ( - 1.0 ) ) ) - ( 1.0 ) / tau )) ;
return 0;
}
/*END CVODE*/
static int state () {_reset=0;
{
s = s + (1. - exp(dt*(( alpha * ( 1.0 + tanh ( vpre - voff / rparam ) ) )*( ( ( - 1.0 ) ) ) - ( 1.0 ) / tau)))*(- ( ( ( alpha )*( ( 1.0 + tanh ( vpre - voff / rparam ) ) ) )*( ( 1.0 ) ) + noise ) / ( ( ( alpha )*( ( 1.0 + tanh ( vpre - voff / rparam ) ) ) )*( ( ( - 1.0 ) ) ) - ( 1.0 ) / tau ) - s) ;
}
return 0;
}
static int _ode_count(int _type){ return 1;}
static void _ode_spec(_NrnThread* _nt, _Memb_list* _ml, int _type) {
Datum* _thread;
Node* _nd; double _v; int _iml, _cntml;
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
_nd = _ml->_nodelist[_iml];
v = NODEV(_nd);
_ode_spec1 ();
}}
static void _ode_map(int _ieq, double** _pv, double** _pvdot, double* _pp, Datum* _ppd, double* _atol, int _type) {
int _i; _p = _pp; _ppvar = _ppd;
_cvode_ieq = _ieq;
for (_i=0; _i < 1; ++_i) {
_pv[_i] = _pp + _slist1[_i]; _pvdot[_i] = _pp + _dlist1[_i];
_cvode_abstol(_atollist, _atol, _i);
}
}
static void _ode_matsol_instance1(_threadargsproto_) {
_ode_matsol1 ();
}
static void _ode_matsol(_NrnThread* _nt, _Memb_list* _ml, int _type) {
Datum* _thread;
Node* _nd; double _v; int _iml, _cntml;
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
_nd = _ml->_nodelist[_iml];
v = NODEV(_nd);
_ode_matsol_instance1(_threadargs_);
}}
static void initmodel() {
int _i; double _save;_ninits++;
_save = t;
t = 0.0;
{
s = s0;
{
s = 0.0 ;
}
_sav_indep = t; t = _save;
}
}
static void nrn_init(_NrnThread* _nt, _Memb_list* _ml, int _type){
Node *_nd; double _v; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
v = _v;
initmodel();
}}
static double _nrn_current(double _v){double _current=0.;v=_v;{ {
i = g * s * ( v - e ) ;
}
_current += i;
} return _current;
}
static void nrn_cur(_NrnThread* _nt, _Memb_list* _ml, int _type){
Node *_nd; int* _ni; double _rhs, _v; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
_g = _nrn_current(_v + .001);
{ _rhs = _nrn_current(_v);
}
_g = (_g - _rhs)/.001;
_g *= 1.e2/(_nd_area);
_rhs *= 1.e2/(_nd_area);
#if CACHEVEC
if (use_cachevec) {
VEC_RHS(_ni[_iml]) -= _rhs;
}else
#endif
{
NODERHS(_nd) -= _rhs;
}
}}
static void nrn_jacob(_NrnThread* _nt, _Memb_list* _ml, int _type){
Node *_nd; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml];
#if CACHEVEC
if (use_cachevec) {
VEC_D(_ni[_iml]) += _g;
}else
#endif
{
_nd = _ml->_nodelist[_iml];
NODED(_nd) += _g;
}
}}
static void nrn_state(_NrnThread* _nt, _Memb_list* _ml, int _type){
Node *_nd; double _v = 0.0; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
_nd = _ml->_nodelist[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
v=_v;
{
{ error = state();
if(error){fprintf(stderr,"at line 46 in file noisytanhsyn.mod:\n SOLVE state METHOD cnexp\n"); nrn_complain(_p); abort_run(error);}
}}}
}
static void terminal(){}
static void _initlists() {
int _i; static int _first = 1;
if (!_first) return;
_slist1[0] = &(s) - _p; _dlist1[0] = &(Ds) - _p;
_first = 0;
}
#if NMODL_TEXT
static const char* nmodl_filename = "noisytanhsyn.mod";
static const char* nmodl_file_text =
"TITLE Continuous and instantaneous tanh-type synaptic transmission mechanism\n"
"COMMENT\n"
" The presynaptic membrane potential can be specified via setpointer\n"
" in the hoc file.\n"
"ENDCOMMENT\n"
"\n"
"NEURON {\n"
" POINT_PROCESS tanhSyn\n"
" RANGE tau, e, i, noise, alpha, s, g, rparam, voff\n"
" NONSPECIFIC_CURRENT i\n"
" POINTER vpre\n"
"}\n"
"\n"
"UNITS {\n"
" (uS) = (microsiemens)\n"
" (mS) = (millisiemens)\n"
" (mV) = (millivolt)\n"
" (mA) = (milliamp)\n"
"}\n"
"\n"
"PARAMETER {\n"
" e = 0 (mV)\n"
" alpha = 0.55\n"
" tau = 5.26 (ms) <1e-9,1e9>\n"
" noise = 0\n"
" g = 2.7e-4 (uS)\n"
" rparam = 4\n"
" voff = 0 (mV)\n"
"}\n"
"\n"
"ASSIGNED {\n"
" v (mV)\n"
" vpre (mV)\n"
" i (nA)\n"
"}\n"
"\n"
"STATE {\n"
" s\n"
"}\n"
"\n"
"INITIAL {\n"
" s=0\n"
"}\n"
"\n"
"BREAKPOINT {\n"
" SOLVE state METHOD cnexp\n"
" i = g*s*(v - e)\n"
"}\n"
"\n"
"DERIVATIVE state {\n"
" s' = alpha*(1+tanh(vpre-voff/rparam))*(1-s) - s/tau + noise\n"
"}\n"
;
#endif