/* Created by Language version: 7.7.0 */
/* NOT VECTORIZED */
#define NRN_VECTORIZED 0
#include <stdio.h>
#include <stdlib.h>
#include <math.h>
#include "scoplib_ansi.h"
#undef PI
#define nil 0
#include "md1redef.h"
#include "section.h"
#include "nrniv_mf.h"
#include "md2redef.h"
#if METHOD3
extern int _method3;
#endif
#if !NRNGPU
#undef exp
#define exp hoc_Exp
extern double hoc_Exp(double);
#endif
#define nrn_init _nrn_init__pcIhcn
#define _nrn_initial _nrn_initial__pcIhcn
#define nrn_cur _nrn_cur__pcIhcn
#define _nrn_current _nrn_current__pcIhcn
#define nrn_jacob _nrn_jacob__pcIhcn
#define nrn_state _nrn_state__pcIhcn
#define _net_receive _net_receive__pcIhcn
#define rates rates__pcIhcn
#define states states__pcIhcn
#define _threadargscomma_ /**/
#define _threadargsprotocomma_ /**/
#define _threadargs_ /**/
#define _threadargsproto_ /**/
/*SUPPRESS 761*/
/*SUPPRESS 762*/
/*SUPPRESS 763*/
/*SUPPRESS 765*/
extern double *getarg();
static double *_p; static Datum *_ppvar;
#define t nrn_threads->_t
#define dt nrn_threads->_dt
#define ghbar _p[0]
#define eh _p[1]
#define i _p[2]
#define n _p[3]
#define qt _p[4]
#define Dn _p[5]
#define _g _p[6]
#if MAC
#if !defined(v)
#define v _mlhv
#endif
#if !defined(h)
#define h _mlhh
#endif
#endif
#if defined(__cplusplus)
extern "C" {
#endif
static int hoc_nrnpointerindex = -1;
/* external NEURON variables */
extern double celsius;
/* declaration of user functions */
static void _hoc_rates(void);
static int _mechtype;
extern void _nrn_cacheloop_reg(int, int);
extern void hoc_register_prop_size(int, int, int);
extern void hoc_register_limits(int, HocParmLimits*);
extern void hoc_register_units(int, HocParmUnits*);
extern void nrn_promote(Prop*, int, int);
extern Memb_func* memb_func;
#define NMODL_TEXT 1
#if NMODL_TEXT
static const char* nmodl_file_text;
static const char* nmodl_filename;
extern void hoc_reg_nmodl_text(int, const char*);
extern void hoc_reg_nmodl_filename(int, const char*);
#endif
extern void _nrn_setdata_reg(int, void(*)(Prop*));
static void _setdata(Prop* _prop) {
_p = _prop->param; _ppvar = _prop->dparam;
}
static void _hoc_setdata() {
Prop *_prop, *hoc_getdata_range(int);
_prop = hoc_getdata_range(_mechtype);
_setdata(_prop);
hoc_retpushx(1.);
}
/* connect user functions to hoc names */
static VoidFunc hoc_intfunc[] = {
"setdata_pcIhcn", _hoc_setdata,
"rates_pcIhcn", _hoc_rates,
0, 0
};
/* declare global and static user variables */
#define ninf ninf_pcIhcn
double ninf = 0;
#define taun taun_pcIhcn
double taun = 0;
/* some parameters have upper and lower limits */
static HocParmLimits _hoc_parm_limits[] = {
0,0,0
};
static HocParmUnits _hoc_parm_units[] = {
"taun_pcIhcn", "ms",
"ghbar_pcIhcn", "S/cm2",
"eh_pcIhcn", "mV",
"i_pcIhcn", "mA/cm2",
0,0
};
static double delta_t = 0.01;
static double n0 = 0;
static double v = 0;
/* connect global user variables to hoc */
static DoubScal hoc_scdoub[] = {
"ninf_pcIhcn", &ninf_pcIhcn,
"taun_pcIhcn", &taun_pcIhcn,
0,0
};
static DoubVec hoc_vdoub[] = {
0,0,0
};
static double _sav_indep;
static void nrn_alloc(Prop*);
static void nrn_init(_NrnThread*, _Memb_list*, int);
static void nrn_state(_NrnThread*, _Memb_list*, int);
static void nrn_cur(_NrnThread*, _Memb_list*, int);
static void nrn_jacob(_NrnThread*, _Memb_list*, int);
static int _ode_count(int);
static void _ode_map(int, double**, double**, double*, Datum*, double*, int);
static void _ode_spec(_NrnThread*, _Memb_list*, int);
static void _ode_matsol(_NrnThread*, _Memb_list*, int);
#define _cvode_ieq _ppvar[0]._i
static void _ode_matsol_instance1(_threadargsproto_);
/* connect range variables in _p that hoc is supposed to know about */
static const char *_mechanism[] = {
"7.7.0",
"pcIhcn",
"ghbar_pcIhcn",
"eh_pcIhcn",
0,
"i_pcIhcn",
0,
"n_pcIhcn",
0,
0};
extern Prop* need_memb(Symbol*);
static void nrn_alloc(Prop* _prop) {
Prop *prop_ion;
double *_p; Datum *_ppvar;
_p = nrn_prop_data_alloc(_mechtype, 7, _prop);
/*initialize range parameters*/
ghbar = 0.0002;
eh = -30;
_prop->param = _p;
_prop->param_size = 7;
_ppvar = nrn_prop_datum_alloc(_mechtype, 1, _prop);
_prop->dparam = _ppvar;
/*connect ionic variables to this model*/
}
static void _initlists();
/* some states have an absolute tolerance */
static Symbol** _atollist;
static HocStateTolerance _hoc_state_tol[] = {
0,0
};
extern Symbol* hoc_lookup(const char*);
extern void _nrn_thread_reg(int, int, void(*)(Datum*));
extern void _nrn_thread_table_reg(int, void(*)(double*, Datum*, Datum*, _NrnThread*, int));
extern void hoc_register_tolerance(int, HocStateTolerance*, Symbol***);
extern void _cvode_abstol( Symbol**, double*, int);
void _pc_Ihcn_reg() {
int _vectorized = 0;
_initlists();
register_mech(_mechanism, nrn_alloc,nrn_cur, nrn_jacob, nrn_state, nrn_init, hoc_nrnpointerindex, 0);
_mechtype = nrn_get_mechtype(_mechanism[1]);
_nrn_setdata_reg(_mechtype, _setdata);
#if NMODL_TEXT
hoc_reg_nmodl_text(_mechtype, nmodl_file_text);
hoc_reg_nmodl_filename(_mechtype, nmodl_filename);
#endif
hoc_register_prop_size(_mechtype, 7, 1);
hoc_register_dparam_semantics(_mechtype, 0, "cvodeieq");
hoc_register_cvode(_mechtype, _ode_count, _ode_map, _ode_spec, _ode_matsol);
hoc_register_tolerance(_mechtype, _hoc_state_tol, &_atollist);
hoc_register_var(hoc_scdoub, hoc_vdoub, hoc_intfunc);
ivoc_help("help ?1 pcIhcn D:/Projects/SchreglmannEtAl2020/CCTC_model/modfiles/pc_Ihcn.mod\n");
hoc_register_limits(_mechtype, _hoc_parm_limits);
hoc_register_units(_mechtype, _hoc_parm_units);
}
static double q10 = 2.2;
static double cvn = 90.1;
static double ckn = -9.9;
static double cct = 0.19;
static double cat = 0.72;
static double cvt = 81.5;
static double ckt = 11.9;
static int _reset;
static char *modelname = "Ih current from HCN1 units";
static int error;
static int _ninits = 0;
static int _match_recurse=1;
static void _modl_cleanup(){ _match_recurse=1;}
static int rates(double);
static int _ode_spec1(_threadargsproto_);
/*static int _ode_matsol1(_threadargsproto_);*/
static int _slist1[1], _dlist1[1];
static int states(_threadargsproto_);
/*CVODE*/
static int _ode_spec1 () {_reset=0;
{
rates ( _threadargscomma_ v ) ;
Dn = ( ninf - n ) / taun ;
}
return _reset;
}
static int _ode_matsol1 () {
rates ( _threadargscomma_ v ) ;
Dn = Dn / (1. - dt*( ( ( ( - 1.0 ) ) ) / taun )) ;
return 0;
}
/*END CVODE*/
static int states () {_reset=0;
{
rates ( _threadargscomma_ v ) ;
n = n + (1. - exp(dt*(( ( ( - 1.0 ) ) ) / taun)))*(- ( ( ( ninf ) ) / taun ) / ( ( ( ( - 1.0 ) ) ) / taun ) - n) ;
}
return 0;
}
static int rates ( double _lv ) {
ninf = 1.0 / ( 1.0 + exp ( - ( _lv + cvn ) / ckn ) ) ;
taun = ( 1e3 ) * ( cct + cat * exp ( - pow( ( ( _lv + cvt ) / ckt ) , 2.0 ) ) ) / qt ;
return 0; }
static void _hoc_rates(void) {
double _r;
_r = 1.;
rates ( *getarg(1) );
hoc_retpushx(_r);
}
static int _ode_count(int _type){ return 1;}
static void _ode_spec(_NrnThread* _nt, _Memb_list* _ml, int _type) {
Datum* _thread;
Node* _nd; double _v; int _iml, _cntml;
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
_nd = _ml->_nodelist[_iml];
v = NODEV(_nd);
_ode_spec1 ();
}}
static void _ode_map(int _ieq, double** _pv, double** _pvdot, double* _pp, Datum* _ppd, double* _atol, int _type) {
int _i; _p = _pp; _ppvar = _ppd;
_cvode_ieq = _ieq;
for (_i=0; _i < 1; ++_i) {
_pv[_i] = _pp + _slist1[_i]; _pvdot[_i] = _pp + _dlist1[_i];
_cvode_abstol(_atollist, _atol, _i);
}
}
static void _ode_matsol_instance1(_threadargsproto_) {
_ode_matsol1 ();
}
static void _ode_matsol(_NrnThread* _nt, _Memb_list* _ml, int _type) {
Datum* _thread;
Node* _nd; double _v; int _iml, _cntml;
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
_nd = _ml->_nodelist[_iml];
v = NODEV(_nd);
_ode_matsol_instance1(_threadargs_);
}}
static void initmodel() {
int _i; double _save;_ninits++;
_save = t;
t = 0.0;
{
n = n0;
{
qt = pow( q10 , ( ( celsius - 22.0 ) / 10.0 ) ) ;
rates ( _threadargscomma_ v ) ;
n = ninf ;
}
_sav_indep = t; t = _save;
}
}
static void nrn_init(_NrnThread* _nt, _Memb_list* _ml, int _type){
Node *_nd; double _v; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
v = _v;
initmodel();
}}
static double _nrn_current(double _v){double _current=0.;v=_v;{ {
i = ghbar * n * ( v - eh ) ;
}
_current += i;
} return _current;
}
static void nrn_cur(_NrnThread* _nt, _Memb_list* _ml, int _type){
Node *_nd; int* _ni; double _rhs, _v; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
_g = _nrn_current(_v + .001);
{ _rhs = _nrn_current(_v);
}
_g = (_g - _rhs)/.001;
#if CACHEVEC
if (use_cachevec) {
VEC_RHS(_ni[_iml]) -= _rhs;
}else
#endif
{
NODERHS(_nd) -= _rhs;
}
}}
static void nrn_jacob(_NrnThread* _nt, _Memb_list* _ml, int _type){
Node *_nd; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml];
#if CACHEVEC
if (use_cachevec) {
VEC_D(_ni[_iml]) += _g;
}else
#endif
{
_nd = _ml->_nodelist[_iml];
NODED(_nd) += _g;
}
}}
static void nrn_state(_NrnThread* _nt, _Memb_list* _ml, int _type){
Node *_nd; double _v = 0.0; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
_nd = _ml->_nodelist[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
v=_v;
{
{ error = states();
if(error){fprintf(stderr,"at line 69 in file pc_Ihcn.mod:\n SOLVE states METHOD cnexp\n"); nrn_complain(_p); abort_run(error);}
}}}
}
static void terminal(){}
static void _initlists() {
int _i; static int _first = 1;
if (!_first) return;
_slist1[0] = &(n) - _p; _dlist1[0] = &(Dn) - _p;
_first = 0;
}
#if NMODL_TEXT
static const char* nmodl_filename = "pc_Ihcn.mod";
static const char* nmodl_file_text =
"TITLE Ih current from HCN1 units\n"
"\n"
"COMMENT\n"
"\n"
"NEURON implementation of a HCN-channel\n"
"Kinetical Scheme: Hodgkin-Huxley (n)\n"
"\n"
"Modified from: Khaliq et al., J.Neurosci. 23(2003)4899\n"
"\n"
"Laboratory for Neuronal Circuit Dynamics\n"
"RIKEN Brain Science Institute, Wako City, Japan\n"
"http://www.neurodynamics.brain.riken.jp\n"
"\n"
"Reference: Akemann and Knoepfel, J.Neurosci. 26 (2006) 4602\n"
"Date of Implementation: April 2005\n"
"Contact: akemann@brain.riken.jp\n"
"\n"
"ENDCOMMENT\n"
"\n"
"NEURON {\n"
" SUFFIX pcIhcn\n"
" NONSPECIFIC_CURRENT i\n"
" RANGE i, ghbar, eh\n"
" GLOBAL ninf, taun\n"
"}\n"
"\n"
"UNITS {\n"
" (mA) = (milliamp)\n"
" (mV) = (millivolt)\n"
" (S) = (siemens)\n"
"}\n"
"\n"
"CONSTANT {\n"
" q10 = 2.2\n"
" \n"
" cvn = 90.1 (mV)\n"
" ckn = -9.9 (mV)\n"
" \n"
" cct = 0.19 (s)\n"
" cat = 0.72 (s)\n"
" cvt = 81.5 (mV)\n"
" ckt = 11.9 (mV)\n"
"}\n"
"\n"
"PARAMETER {\n"
" v (mV)\n"
" celsius (degC)\n"
" \n"
" ghbar = 0.0002 (S/cm2)\n"
" eh = -30 (mV)\n"
"}\n"
"\n"
"ASSIGNED {\n"
" i (mA/cm2)\n"
" qt\n"
" ninf\n"
" taun (ms)\n"
"}\n"
"\n"
"STATE { n }\n"
"\n"
"INITIAL {\n"
" qt = q10^((celsius-22 (degC))/10 (degC))\n"
" rates(v)\n"
" n = ninf\n"
"}\n"
"\n"
"BREAKPOINT {\n"
" SOLVE states METHOD cnexp\n"
" i = ghbar * n * (v - eh)\n"
"}\n"
"\n"
"DERIVATIVE states {\n"
" rates(v)\n"
" n' = (ninf-n)/taun\n"
"}\n"
"\n"
"PROCEDURE rates(v (mV)) {\n"
" ninf = 1 / ( 1+exp(-(v+cvn)/ckn) )\n"
" taun = (1e3) * ( cct + cat * exp(-((v+cvt)/ckt)^2) ) / qt\n"
"}\n"
;
#endif