/* Created by Language version: 7.7.0 */
/* NOT VECTORIZED */
#define NRN_VECTORIZED 0
#include <stdio.h>
#include <stdlib.h>
#include <math.h>
#include "scoplib_ansi.h"
#undef PI
#define nil 0
#include "md1redef.h"
#include "section.h"
#include "nrniv_mf.h"
#include "md2redef.h"
#if METHOD3
extern int _method3;
#endif
#if !NRNGPU
#undef exp
#define exp hoc_Exp
extern double hoc_Exp(double);
#endif
#define nrn_init _nrn_init__pcNarsg
#define _nrn_initial _nrn_initial__pcNarsg
#define nrn_cur _nrn_cur__pcNarsg
#define _nrn_current _nrn_current__pcNarsg
#define nrn_jacob _nrn_jacob__pcNarsg
#define nrn_state _nrn_state__pcNarsg
#define _net_receive _net_receive__pcNarsg
#define activation activation__pcNarsg
#define rates rates__pcNarsg
#define _threadargscomma_ /**/
#define _threadargsprotocomma_ /**/
#define _threadargs_ /**/
#define _threadargsproto_ /**/
/*SUPPRESS 761*/
/*SUPPRESS 762*/
/*SUPPRESS 763*/
/*SUPPRESS 765*/
extern double *getarg();
static double *_p; static Datum *_ppvar;
#define t nrn_threads->_t
#define dt nrn_threads->_dt
#define gbar _p[0]
#define ina _p[1]
#define g _p[2]
#define C1 _p[3]
#define C2 _p[4]
#define C3 _p[5]
#define C4 _p[6]
#define C5 _p[7]
#define I1 _p[8]
#define I2 _p[9]
#define I3 _p[10]
#define I4 _p[11]
#define I5 _p[12]
#define O _p[13]
#define B _p[14]
#define I6 _p[15]
#define alfac _p[16]
#define btfac _p[17]
#define f01 _p[18]
#define f02 _p[19]
#define f03 _p[20]
#define f04 _p[21]
#define f0O _p[22]
#define fip _p[23]
#define f11 _p[24]
#define f12 _p[25]
#define f13 _p[26]
#define f14 _p[27]
#define f1n _p[28]
#define fi1 _p[29]
#define fi2 _p[30]
#define fi3 _p[31]
#define fi4 _p[32]
#define fi5 _p[33]
#define fin _p[34]
#define b01 _p[35]
#define b02 _p[36]
#define b03 _p[37]
#define b04 _p[38]
#define b0O _p[39]
#define bip _p[40]
#define b11 _p[41]
#define b12 _p[42]
#define b13 _p[43]
#define b14 _p[44]
#define b1n _p[45]
#define bi1 _p[46]
#define bi2 _p[47]
#define bi3 _p[48]
#define bi4 _p[49]
#define bi5 _p[50]
#define bin _p[51]
#define ena _p[52]
#define qt _p[53]
#define DC1 _p[54]
#define DC2 _p[55]
#define DC3 _p[56]
#define DC4 _p[57]
#define DC5 _p[58]
#define DI1 _p[59]
#define DI2 _p[60]
#define DI3 _p[61]
#define DI4 _p[62]
#define DI5 _p[63]
#define DO _p[64]
#define DB _p[65]
#define DI6 _p[66]
#define _g _p[67]
#define _ion_ena *_ppvar[0]._pval
#define _ion_ina *_ppvar[1]._pval
#define _ion_dinadv *_ppvar[2]._pval
#if MAC
#if !defined(v)
#define v _mlhv
#endif
#if !defined(h)
#define h _mlhh
#endif
#endif
#if defined(__cplusplus)
extern "C" {
#endif
static int hoc_nrnpointerindex = -1;
/* external NEURON variables */
extern double celsius;
/* declaration of user functions */
static void _hoc_rates(void);
static int _mechtype;
extern void _nrn_cacheloop_reg(int, int);
extern void hoc_register_prop_size(int, int, int);
extern void hoc_register_limits(int, HocParmLimits*);
extern void hoc_register_units(int, HocParmUnits*);
extern void nrn_promote(Prop*, int, int);
extern Memb_func* memb_func;
#define NMODL_TEXT 1
#if NMODL_TEXT
static const char* nmodl_file_text;
static const char* nmodl_filename;
extern void hoc_reg_nmodl_text(int, const char*);
extern void hoc_reg_nmodl_filename(int, const char*);
#endif
extern void _nrn_setdata_reg(int, void(*)(Prop*));
static void _setdata(Prop* _prop) {
_p = _prop->param; _ppvar = _prop->dparam;
}
static void _hoc_setdata() {
Prop *_prop, *hoc_getdata_range(int);
_prop = hoc_getdata_range(_mechtype);
_setdata(_prop);
hoc_retpushx(1.);
}
/* connect user functions to hoc names */
static VoidFunc hoc_intfunc[] = {
"setdata_pcNarsg", _hoc_setdata,
"rates_pcNarsg", _hoc_rates,
0, 0
};
/* declare global and static user variables */
#define Coff Coff_pcNarsg
double Coff = 0.5;
#define Con Con_pcNarsg
double Con = 0.005;
#define Ooff Ooff_pcNarsg
double Ooff = 0.005;
#define Oon Oon_pcNarsg
double Oon = 0.75;
#define alpha alpha_pcNarsg
double alpha = 150;
#define beta beta_pcNarsg
double beta = 3;
#define delta delta_pcNarsg
double delta = 40;
#define epsilon epsilon_pcNarsg
double epsilon = 1.75;
#define gamma gamma_pcNarsg
double gamma = 150;
#define x6 x6_pcNarsg
double x6 = -25;
#define x5 x5_pcNarsg
double x5 = 1e+012;
#define x4 x4_pcNarsg
double x4 = -1e+012;
#define x3 x3_pcNarsg
double x3 = 1e+012;
#define x2 x2_pcNarsg
double x2 = -20;
#define x1 x1_pcNarsg
double x1 = 20;
#define zeta zeta_pcNarsg
double zeta = 0.03;
/* some parameters have upper and lower limits */
static HocParmLimits _hoc_parm_limits[] = {
0,0,0
};
static HocParmUnits _hoc_parm_units[] = {
"Con_pcNarsg", "/ms",
"Coff_pcNarsg", "/ms",
"Oon_pcNarsg", "/ms",
"Ooff_pcNarsg", "/ms",
"alpha_pcNarsg", "/ms",
"beta_pcNarsg", "/ms",
"gamma_pcNarsg", "/ms",
"delta_pcNarsg", "/ms",
"epsilon_pcNarsg", "/ms",
"zeta_pcNarsg", "/ms",
"x1_pcNarsg", "mV",
"x2_pcNarsg", "mV",
"x3_pcNarsg", "mV",
"x4_pcNarsg", "mV",
"x5_pcNarsg", "mV",
"x6_pcNarsg", "mV",
"gbar_pcNarsg", "S/cm2",
"ina_pcNarsg", "milliamp/cm2",
"g_pcNarsg", "S/cm2",
0,0
};
static double B0 = 0;
static double C50 = 0;
static double C40 = 0;
static double C30 = 0;
static double C20 = 0;
static double C10 = 0;
static double I60 = 0;
static double I50 = 0;
static double I40 = 0;
static double I30 = 0;
static double I20 = 0;
static double I10 = 0;
static double O0 = 0;
static double delta_t = 0.01;
static double v = 0;
/* connect global user variables to hoc */
static DoubScal hoc_scdoub[] = {
"Con_pcNarsg", &Con_pcNarsg,
"Coff_pcNarsg", &Coff_pcNarsg,
"Oon_pcNarsg", &Oon_pcNarsg,
"Ooff_pcNarsg", &Ooff_pcNarsg,
"alpha_pcNarsg", &alpha_pcNarsg,
"beta_pcNarsg", &beta_pcNarsg,
"gamma_pcNarsg", &gamma_pcNarsg,
"delta_pcNarsg", &delta_pcNarsg,
"epsilon_pcNarsg", &epsilon_pcNarsg,
"zeta_pcNarsg", &zeta_pcNarsg,
"x1_pcNarsg", &x1_pcNarsg,
"x2_pcNarsg", &x2_pcNarsg,
"x3_pcNarsg", &x3_pcNarsg,
"x4_pcNarsg", &x4_pcNarsg,
"x5_pcNarsg", &x5_pcNarsg,
"x6_pcNarsg", &x6_pcNarsg,
0,0
};
static DoubVec hoc_vdoub[] = {
0,0,0
};
static double _sav_indep;
static void nrn_alloc(Prop*);
static void nrn_init(_NrnThread*, _Memb_list*, int);
static void nrn_state(_NrnThread*, _Memb_list*, int);
static void nrn_cur(_NrnThread*, _Memb_list*, int);
static void nrn_jacob(_NrnThread*, _Memb_list*, int);
static int _ode_count(int);
static void _ode_map(int, double**, double**, double*, Datum*, double*, int);
static void _ode_spec(_NrnThread*, _Memb_list*, int);
static void _ode_matsol(_NrnThread*, _Memb_list*, int);
#define _cvode_ieq _ppvar[3]._i
static void _ode_matsol_instance1(_threadargsproto_);
/* connect range variables in _p that hoc is supposed to know about */
static const char *_mechanism[] = {
"7.7.0",
"pcNarsg",
"gbar_pcNarsg",
0,
"ina_pcNarsg",
"g_pcNarsg",
0,
"C1_pcNarsg",
"C2_pcNarsg",
"C3_pcNarsg",
"C4_pcNarsg",
"C5_pcNarsg",
"I1_pcNarsg",
"I2_pcNarsg",
"I3_pcNarsg",
"I4_pcNarsg",
"I5_pcNarsg",
"O_pcNarsg",
"B_pcNarsg",
"I6_pcNarsg",
0,
0};
static Symbol* _na_sym;
extern Prop* need_memb(Symbol*);
static void nrn_alloc(Prop* _prop) {
Prop *prop_ion;
double *_p; Datum *_ppvar;
_p = nrn_prop_data_alloc(_mechtype, 68, _prop);
/*initialize range parameters*/
gbar = 0.016;
_prop->param = _p;
_prop->param_size = 68;
_ppvar = nrn_prop_datum_alloc(_mechtype, 4, _prop);
_prop->dparam = _ppvar;
/*connect ionic variables to this model*/
prop_ion = need_memb(_na_sym);
nrn_promote(prop_ion, 0, 1);
_ppvar[0]._pval = &prop_ion->param[0]; /* ena */
_ppvar[1]._pval = &prop_ion->param[3]; /* ina */
_ppvar[2]._pval = &prop_ion->param[4]; /* _ion_dinadv */
}
static void _initlists();
/* some states have an absolute tolerance */
static Symbol** _atollist;
static HocStateTolerance _hoc_state_tol[] = {
0,0
};
static void _update_ion_pointer(Datum*);
extern Symbol* hoc_lookup(const char*);
extern void _nrn_thread_reg(int, int, void(*)(Datum*));
extern void _nrn_thread_table_reg(int, void(*)(double*, Datum*, Datum*, _NrnThread*, int));
extern void hoc_register_tolerance(int, HocStateTolerance*, Symbol***);
extern void _cvode_abstol( Symbol**, double*, int);
void _pc_Narsg_reg() {
int _vectorized = 0;
_initlists();
ion_reg("na", -10000.);
_na_sym = hoc_lookup("na_ion");
register_mech(_mechanism, nrn_alloc,nrn_cur, nrn_jacob, nrn_state, nrn_init, hoc_nrnpointerindex, 0);
_mechtype = nrn_get_mechtype(_mechanism[1]);
_nrn_setdata_reg(_mechtype, _setdata);
_nrn_thread_reg(_mechtype, 2, _update_ion_pointer);
#if NMODL_TEXT
hoc_reg_nmodl_text(_mechtype, nmodl_file_text);
hoc_reg_nmodl_filename(_mechtype, nmodl_filename);
#endif
hoc_register_prop_size(_mechtype, 68, 4);
hoc_register_dparam_semantics(_mechtype, 0, "na_ion");
hoc_register_dparam_semantics(_mechtype, 1, "na_ion");
hoc_register_dparam_semantics(_mechtype, 2, "na_ion");
hoc_register_dparam_semantics(_mechtype, 3, "cvodeieq");
hoc_register_cvode(_mechtype, _ode_count, _ode_map, _ode_spec, _ode_matsol);
hoc_register_tolerance(_mechtype, _hoc_state_tol, &_atollist);
hoc_register_var(hoc_scdoub, hoc_vdoub, hoc_intfunc);
ivoc_help("help ?1 pcNarsg D:/Projects/SchreglmannEtAl2020/CCTC_model/modfiles/pc_Narsg.mod\n");
hoc_register_limits(_mechtype, _hoc_parm_limits);
hoc_register_units(_mechtype, _hoc_parm_units);
}
static double q10 = 2.2;
static int _reset;
static char *modelname = "resurgent sodium channel";
static int error;
static int _ninits = 0;
static int _match_recurse=1;
static void _modl_cleanup(){ _match_recurse=1;}
static int rates(double);
extern double *_getelm();
#define _MATELM1(_row,_col) *(_getelm(_row + 1, _col + 1))
#define _RHS1(_arg) _coef1[_arg + 1]
static double *_coef1;
#define _linmat1 1
static void* _sparseobj1;
static void* _cvsparseobj1;
static int _ode_spec1(_threadargsproto_);
/*static int _ode_matsol1(_threadargsproto_);*/
#define _RHS2(arg) _coef2[arg][13]
static int _slist2[13];static double **_coef2;
static void seqinitial();
static int _slist1[13], _dlist1[13]; static double *_temp1;
static int activation();
static int activation ()
{_reset=0;
{
double b_flux, f_flux, _term; int _i;
{int _i; double _dt1 = 1.0/dt;
for(_i=1;_i<13;_i++){
_RHS1(_i) = -_dt1*(_p[_slist1[_i]] - _p[_dlist1[_i]]);
_MATELM1(_i, _i) = _dt1;
} }
rates ( _threadargscomma_ v ) ;
/* ~ C1 <-> C2 ( f01 , b01 )*/
f_flux = f01 * C1 ;
b_flux = b01 * C2 ;
_RHS1( 6) -= (f_flux - b_flux);
_RHS1( 5) += (f_flux - b_flux);
_term = f01 ;
_MATELM1( 6 ,6) += _term;
_MATELM1( 5 ,6) -= _term;
_term = b01 ;
_MATELM1( 6 ,5) -= _term;
_MATELM1( 5 ,5) += _term;
/*REACTION*/
/* ~ C2 <-> C3 ( f02 , b02 )*/
f_flux = f02 * C2 ;
b_flux = b02 * C3 ;
_RHS1( 5) -= (f_flux - b_flux);
_RHS1( 4) += (f_flux - b_flux);
_term = f02 ;
_MATELM1( 5 ,5) += _term;
_MATELM1( 4 ,5) -= _term;
_term = b02 ;
_MATELM1( 5 ,4) -= _term;
_MATELM1( 4 ,4) += _term;
/*REACTION*/
/* ~ C3 <-> C4 ( f03 , b03 )*/
f_flux = f03 * C3 ;
b_flux = b03 * C4 ;
_RHS1( 4) -= (f_flux - b_flux);
_RHS1( 3) += (f_flux - b_flux);
_term = f03 ;
_MATELM1( 4 ,4) += _term;
_MATELM1( 3 ,4) -= _term;
_term = b03 ;
_MATELM1( 4 ,3) -= _term;
_MATELM1( 3 ,3) += _term;
/*REACTION*/
/* ~ C4 <-> C5 ( f04 , b04 )*/
f_flux = f04 * C4 ;
b_flux = b04 * C5 ;
_RHS1( 3) -= (f_flux - b_flux);
_RHS1( 2) += (f_flux - b_flux);
_term = f04 ;
_MATELM1( 3 ,3) += _term;
_MATELM1( 2 ,3) -= _term;
_term = b04 ;
_MATELM1( 3 ,2) -= _term;
_MATELM1( 2 ,2) += _term;
/*REACTION*/
/* ~ C5 <-> O ( f0O , b0O )*/
f_flux = f0O * C5 ;
b_flux = b0O * O ;
_RHS1( 2) -= (f_flux - b_flux);
_RHS1( 12) += (f_flux - b_flux);
_term = f0O ;
_MATELM1( 2 ,2) += _term;
_MATELM1( 12 ,2) -= _term;
_term = b0O ;
_MATELM1( 2 ,12) -= _term;
_MATELM1( 12 ,12) += _term;
/*REACTION*/
/* ~ O <-> B ( fip , bip )*/
f_flux = fip * O ;
b_flux = bip * B ;
_RHS1( 12) -= (f_flux - b_flux);
_RHS1( 1) += (f_flux - b_flux);
_term = fip ;
_MATELM1( 12 ,12) += _term;
_MATELM1( 1 ,12) -= _term;
_term = bip ;
_MATELM1( 12 ,1) -= _term;
_MATELM1( 1 ,1) += _term;
/*REACTION*/
/* ~ O <-> I6 ( fin , bin )*/
f_flux = fin * O ;
b_flux = bin * I6 ;
_RHS1( 12) -= (f_flux - b_flux);
_term = fin ;
_MATELM1( 12 ,12) += _term;
_term = bin ;
_MATELM1( 12 ,0) -= _term;
/*REACTION*/
/* ~ I1 <-> I2 ( f11 , b11 )*/
f_flux = f11 * I1 ;
b_flux = b11 * I2 ;
_RHS1( 11) -= (f_flux - b_flux);
_RHS1( 10) += (f_flux - b_flux);
_term = f11 ;
_MATELM1( 11 ,11) += _term;
_MATELM1( 10 ,11) -= _term;
_term = b11 ;
_MATELM1( 11 ,10) -= _term;
_MATELM1( 10 ,10) += _term;
/*REACTION*/
/* ~ I2 <-> I3 ( f12 , b12 )*/
f_flux = f12 * I2 ;
b_flux = b12 * I3 ;
_RHS1( 10) -= (f_flux - b_flux);
_RHS1( 9) += (f_flux - b_flux);
_term = f12 ;
_MATELM1( 10 ,10) += _term;
_MATELM1( 9 ,10) -= _term;
_term = b12 ;
_MATELM1( 10 ,9) -= _term;
_MATELM1( 9 ,9) += _term;
/*REACTION*/
/* ~ I3 <-> I4 ( f13 , b13 )*/
f_flux = f13 * I3 ;
b_flux = b13 * I4 ;
_RHS1( 9) -= (f_flux - b_flux);
_RHS1( 8) += (f_flux - b_flux);
_term = f13 ;
_MATELM1( 9 ,9) += _term;
_MATELM1( 8 ,9) -= _term;
_term = b13 ;
_MATELM1( 9 ,8) -= _term;
_MATELM1( 8 ,8) += _term;
/*REACTION*/
/* ~ I4 <-> I5 ( f14 , b14 )*/
f_flux = f14 * I4 ;
b_flux = b14 * I5 ;
_RHS1( 8) -= (f_flux - b_flux);
_RHS1( 7) += (f_flux - b_flux);
_term = f14 ;
_MATELM1( 8 ,8) += _term;
_MATELM1( 7 ,8) -= _term;
_term = b14 ;
_MATELM1( 8 ,7) -= _term;
_MATELM1( 7 ,7) += _term;
/*REACTION*/
/* ~ I5 <-> I6 ( f1n , b1n )*/
f_flux = f1n * I5 ;
b_flux = b1n * I6 ;
_RHS1( 7) -= (f_flux - b_flux);
_term = f1n ;
_MATELM1( 7 ,7) += _term;
_term = b1n ;
_MATELM1( 7 ,0) -= _term;
/*REACTION*/
/* ~ C1 <-> I1 ( fi1 , bi1 )*/
f_flux = fi1 * C1 ;
b_flux = bi1 * I1 ;
_RHS1( 6) -= (f_flux - b_flux);
_RHS1( 11) += (f_flux - b_flux);
_term = fi1 ;
_MATELM1( 6 ,6) += _term;
_MATELM1( 11 ,6) -= _term;
_term = bi1 ;
_MATELM1( 6 ,11) -= _term;
_MATELM1( 11 ,11) += _term;
/*REACTION*/
/* ~ C2 <-> I2 ( fi2 , bi2 )*/
f_flux = fi2 * C2 ;
b_flux = bi2 * I2 ;
_RHS1( 5) -= (f_flux - b_flux);
_RHS1( 10) += (f_flux - b_flux);
_term = fi2 ;
_MATELM1( 5 ,5) += _term;
_MATELM1( 10 ,5) -= _term;
_term = bi2 ;
_MATELM1( 5 ,10) -= _term;
_MATELM1( 10 ,10) += _term;
/*REACTION*/
/* ~ C3 <-> I3 ( fi3 , bi3 )*/
f_flux = fi3 * C3 ;
b_flux = bi3 * I3 ;
_RHS1( 4) -= (f_flux - b_flux);
_RHS1( 9) += (f_flux - b_flux);
_term = fi3 ;
_MATELM1( 4 ,4) += _term;
_MATELM1( 9 ,4) -= _term;
_term = bi3 ;
_MATELM1( 4 ,9) -= _term;
_MATELM1( 9 ,9) += _term;
/*REACTION*/
/* ~ C4 <-> I4 ( fi4 , bi4 )*/
f_flux = fi4 * C4 ;
b_flux = bi4 * I4 ;
_RHS1( 3) -= (f_flux - b_flux);
_RHS1( 8) += (f_flux - b_flux);
_term = fi4 ;
_MATELM1( 3 ,3) += _term;
_MATELM1( 8 ,3) -= _term;
_term = bi4 ;
_MATELM1( 3 ,8) -= _term;
_MATELM1( 8 ,8) += _term;
/*REACTION*/
/* ~ C5 <-> I5 ( fi5 , bi5 )*/
f_flux = fi5 * C5 ;
b_flux = bi5 * I5 ;
_RHS1( 2) -= (f_flux - b_flux);
_RHS1( 7) += (f_flux - b_flux);
_term = fi5 ;
_MATELM1( 2 ,2) += _term;
_MATELM1( 7 ,2) -= _term;
_term = bi5 ;
_MATELM1( 2 ,7) -= _term;
_MATELM1( 7 ,7) += _term;
/*REACTION*/
/* C1 + C2 + C3 + C4 + C5 + O + B + I1 + I2 + I3 + I4 + I5 + I6 = 1.0 */
_RHS1(0) = 1.0;
_MATELM1(0, 0) = 1;
_RHS1(0) -= I6 ;
_MATELM1(0, 7) = 1;
_RHS1(0) -= I5 ;
_MATELM1(0, 8) = 1;
_RHS1(0) -= I4 ;
_MATELM1(0, 9) = 1;
_RHS1(0) -= I3 ;
_MATELM1(0, 10) = 1;
_RHS1(0) -= I2 ;
_MATELM1(0, 11) = 1;
_RHS1(0) -= I1 ;
_MATELM1(0, 1) = 1;
_RHS1(0) -= B ;
_MATELM1(0, 12) = 1;
_RHS1(0) -= O ;
_MATELM1(0, 2) = 1;
_RHS1(0) -= C5 ;
_MATELM1(0, 3) = 1;
_RHS1(0) -= C4 ;
_MATELM1(0, 4) = 1;
_RHS1(0) -= C3 ;
_MATELM1(0, 5) = 1;
_RHS1(0) -= C2 ;
_MATELM1(0, 6) = 1;
_RHS1(0) -= C1 ;
/*CONSERVATION*/
} return _reset;
}
static void seqinitial ()
{
zero_matrix(_coef2, 13, 14);
{
int _counte = -1;
++_counte;
_coef2[_counte][0] -= 1.0 * bi1 ;
_coef2[_counte][1] -= 1.0 * b01 ;
_coef2[_counte][2] += 1.0 * ( fi1 + f01 ) ;
_RHS2(_counte) -= 0.0 ;
;
++_counte;
_coef2[_counte][2] -= 1.0 * f01 ;
_coef2[_counte][3] -= 1.0 * bi2 ;
_coef2[_counte][4] -= 1.0 * b02 ;
_coef2[_counte][1] += 1.0 * ( b01 + fi2 + f02 ) ;
_RHS2(_counte) -= 0.0 ;
;
++_counte;
_coef2[_counte][1] -= 1.0 * f02 ;
_coef2[_counte][5] -= 1.0 * bi3 ;
_coef2[_counte][6] -= 1.0 * b03 ;
_coef2[_counte][4] += 1.0 * ( b02 + fi3 + f03 ) ;
_RHS2(_counte) -= 0.0 ;
;
++_counte;
_coef2[_counte][4] -= 1.0 * f03 ;
_coef2[_counte][7] -= 1.0 * bi4 ;
_coef2[_counte][8] -= 1.0 * b04 ;
_coef2[_counte][6] += 1.0 * ( b03 + fi4 + f04 ) ;
_RHS2(_counte) -= 0.0 ;
;
++_counte;
_coef2[_counte][6] -= 1.0 * f04 ;
_coef2[_counte][9] -= 1.0 * bi5 ;
_coef2[_counte][10] -= 1.0 * b0O ;
_coef2[_counte][8] += 1.0 * ( b04 + fi5 + f0O ) ;
_RHS2(_counte) -= 0.0 ;
;
++_counte;
_coef2[_counte][8] -= 1.0 * f0O ;
_coef2[_counte][11] -= 1.0 * bip ;
_coef2[_counte][12] -= 1.0 * bin ;
_coef2[_counte][10] += 1.0 * ( b0O + fip + fin ) ;
_RHS2(_counte) -= 0.0 ;
;
++_counte;
_coef2[_counte][10] -= 1.0 * fip ;
_coef2[_counte][11] += 1.0 * bip ;
_RHS2(_counte) -= 0.0 ;
;
++_counte;
_coef2[_counte][2] -= 1.0 * fi1 ;
_coef2[_counte][3] -= 1.0 * b11 ;
_coef2[_counte][0] += 1.0 * ( bi1 + f11 ) ;
_RHS2(_counte) -= 0.0 ;
;
++_counte;
_coef2[_counte][0] -= 1.0 * f11 ;
_coef2[_counte][1] -= 1.0 * fi2 ;
_coef2[_counte][5] -= 1.0 * b12 ;
_coef2[_counte][3] += 1.0 * ( b11 + bi2 + f12 ) ;
_RHS2(_counte) -= 0.0 ;
;
++_counte;
_coef2[_counte][3] -= 1.0 * f12 ;
_coef2[_counte][4] -= 1.0 * fi3 ;
_coef2[_counte][7] -= 1.0 * bi3 ;
_coef2[_counte][5] += 1.0 * ( b12 + bi3 + f13 ) ;
_RHS2(_counte) -= 0.0 ;
;
++_counte;
_coef2[_counte][5] -= 1.0 * f13 ;
_coef2[_counte][6] -= 1.0 * fi4 ;
_coef2[_counte][9] -= 1.0 * b14 ;
_coef2[_counte][7] += 1.0 * ( b13 + bi4 + f14 ) ;
_RHS2(_counte) -= 0.0 ;
;
++_counte;
_coef2[_counte][7] -= 1.0 * f14 ;
_coef2[_counte][8] -= 1.0 * fi5 ;
_coef2[_counte][12] -= 1.0 * b1n ;
_coef2[_counte][9] += 1.0 * ( b14 + bi5 + f1n ) ;
_RHS2(_counte) -= 0.0 ;
;
++_counte;
_coef2[_counte][2] -= 1.0 ;
_coef2[_counte][1] -= 1.0 ;
_coef2[_counte][4] -= 1.0 ;
_coef2[_counte][6] -= 1.0 ;
_coef2[_counte][8] -= 1.0 ;
_coef2[_counte][10] -= 1.0 ;
_coef2[_counte][11] -= 1.0 ;
_coef2[_counte][0] -= 1.0 ;
_coef2[_counte][3] -= 1.0 ;
_coef2[_counte][5] -= 1.0 ;
_coef2[_counte][7] -= 1.0 ;
_coef2[_counte][9] -= 1.0 ;
_coef2[_counte][12] -= 1.0 ;
_RHS2(_counte) -= 1.0 ;
;
}
}
static int rates ( double _lv ) {
alfac = pow( ( Oon / Con ) , ( 1.0 / 4.0 ) ) ;
btfac = pow( ( Ooff / Coff ) , ( 1.0 / 4.0 ) ) ;
f01 = 4.0 * alpha * exp ( _lv / x1 ) * qt ;
f02 = 3.0 * alpha * exp ( _lv / x1 ) * qt ;
f03 = 2.0 * alpha * exp ( _lv / x1 ) * qt ;
f04 = 1.0 * alpha * exp ( _lv / x1 ) * qt ;
f0O = gamma * exp ( _lv / x3 ) * qt ;
fip = epsilon * exp ( _lv / x5 ) * qt ;
f11 = 4.0 * alpha * alfac * exp ( _lv / x1 ) * qt ;
f12 = 3.0 * alpha * alfac * exp ( _lv / x1 ) * qt ;
f13 = 2.0 * alpha * alfac * exp ( _lv / x1 ) * qt ;
f14 = 1.0 * alpha * alfac * exp ( _lv / x1 ) * qt ;
f1n = gamma * exp ( _lv / x3 ) * qt ;
fi1 = Con * qt ;
fi2 = Con * alfac * qt ;
fi3 = Con * pow( alfac , 2.0 ) * qt ;
fi4 = Con * pow( alfac , 3.0 ) * qt ;
fi5 = Con * pow( alfac , 4.0 ) * qt ;
fin = Oon * qt ;
b01 = 1.0 * beta * exp ( _lv / x2 ) * qt ;
b02 = 2.0 * beta * exp ( _lv / x2 ) * qt ;
b03 = 3.0 * beta * exp ( _lv / x2 ) * qt ;
b04 = 4.0 * beta * exp ( _lv / x2 ) * qt ;
b0O = delta * exp ( _lv / x4 ) * qt ;
bip = zeta * exp ( _lv / x6 ) * qt ;
b11 = 1.0 * beta * btfac * exp ( _lv / x2 ) * qt ;
b12 = 2.0 * beta * btfac * exp ( _lv / x2 ) * qt ;
b13 = 3.0 * beta * btfac * exp ( _lv / x2 ) * qt ;
b14 = 4.0 * beta * btfac * exp ( _lv / x2 ) * qt ;
b1n = delta * exp ( _lv / x4 ) * qt ;
bi1 = Coff * qt ;
bi2 = Coff * btfac * qt ;
bi3 = Coff * pow( btfac , 2.0 ) * qt ;
bi4 = Coff * pow( btfac , 3.0 ) * qt ;
bi5 = Coff * pow( btfac , 4.0 ) * qt ;
bin = Ooff * qt ;
return 0; }
static void _hoc_rates(void) {
double _r;
_r = 1.;
rates ( *getarg(1) );
hoc_retpushx(_r);
}
/*CVODE ode begin*/
static int _ode_spec1() {_reset=0;{
double b_flux, f_flux, _term; int _i;
{int _i; for(_i=0;_i<13;_i++) _p[_dlist1[_i]] = 0.0;}
rates ( _threadargscomma_ v ) ;
/* ~ C1 <-> C2 ( f01 , b01 )*/
f_flux = f01 * C1 ;
b_flux = b01 * C2 ;
DC1 -= (f_flux - b_flux);
DC2 += (f_flux - b_flux);
/*REACTION*/
/* ~ C2 <-> C3 ( f02 , b02 )*/
f_flux = f02 * C2 ;
b_flux = b02 * C3 ;
DC2 -= (f_flux - b_flux);
DC3 += (f_flux - b_flux);
/*REACTION*/
/* ~ C3 <-> C4 ( f03 , b03 )*/
f_flux = f03 * C3 ;
b_flux = b03 * C4 ;
DC3 -= (f_flux - b_flux);
DC4 += (f_flux - b_flux);
/*REACTION*/
/* ~ C4 <-> C5 ( f04 , b04 )*/
f_flux = f04 * C4 ;
b_flux = b04 * C5 ;
DC4 -= (f_flux - b_flux);
DC5 += (f_flux - b_flux);
/*REACTION*/
/* ~ C5 <-> O ( f0O , b0O )*/
f_flux = f0O * C5 ;
b_flux = b0O * O ;
DC5 -= (f_flux - b_flux);
DO += (f_flux - b_flux);
/*REACTION*/
/* ~ O <-> B ( fip , bip )*/
f_flux = fip * O ;
b_flux = bip * B ;
DO -= (f_flux - b_flux);
DB += (f_flux - b_flux);
/*REACTION*/
/* ~ O <-> I6 ( fin , bin )*/
f_flux = fin * O ;
b_flux = bin * I6 ;
DO -= (f_flux - b_flux);
DI6 += (f_flux - b_flux);
/*REACTION*/
/* ~ I1 <-> I2 ( f11 , b11 )*/
f_flux = f11 * I1 ;
b_flux = b11 * I2 ;
DI1 -= (f_flux - b_flux);
DI2 += (f_flux - b_flux);
/*REACTION*/
/* ~ I2 <-> I3 ( f12 , b12 )*/
f_flux = f12 * I2 ;
b_flux = b12 * I3 ;
DI2 -= (f_flux - b_flux);
DI3 += (f_flux - b_flux);
/*REACTION*/
/* ~ I3 <-> I4 ( f13 , b13 )*/
f_flux = f13 * I3 ;
b_flux = b13 * I4 ;
DI3 -= (f_flux - b_flux);
DI4 += (f_flux - b_flux);
/*REACTION*/
/* ~ I4 <-> I5 ( f14 , b14 )*/
f_flux = f14 * I4 ;
b_flux = b14 * I5 ;
DI4 -= (f_flux - b_flux);
DI5 += (f_flux - b_flux);
/*REACTION*/
/* ~ I5 <-> I6 ( f1n , b1n )*/
f_flux = f1n * I5 ;
b_flux = b1n * I6 ;
DI5 -= (f_flux - b_flux);
DI6 += (f_flux - b_flux);
/*REACTION*/
/* ~ C1 <-> I1 ( fi1 , bi1 )*/
f_flux = fi1 * C1 ;
b_flux = bi1 * I1 ;
DC1 -= (f_flux - b_flux);
DI1 += (f_flux - b_flux);
/*REACTION*/
/* ~ C2 <-> I2 ( fi2 , bi2 )*/
f_flux = fi2 * C2 ;
b_flux = bi2 * I2 ;
DC2 -= (f_flux - b_flux);
DI2 += (f_flux - b_flux);
/*REACTION*/
/* ~ C3 <-> I3 ( fi3 , bi3 )*/
f_flux = fi3 * C3 ;
b_flux = bi3 * I3 ;
DC3 -= (f_flux - b_flux);
DI3 += (f_flux - b_flux);
/*REACTION*/
/* ~ C4 <-> I4 ( fi4 , bi4 )*/
f_flux = fi4 * C4 ;
b_flux = bi4 * I4 ;
DC4 -= (f_flux - b_flux);
DI4 += (f_flux - b_flux);
/*REACTION*/
/* ~ C5 <-> I5 ( fi5 , bi5 )*/
f_flux = fi5 * C5 ;
b_flux = bi5 * I5 ;
DC5 -= (f_flux - b_flux);
DI5 += (f_flux - b_flux);
/*REACTION*/
/* C1 + C2 + C3 + C4 + C5 + O + B + I1 + I2 + I3 + I4 + I5 + I6 = 1.0 */
/*CONSERVATION*/
} return _reset;
}
/*CVODE matsol*/
static int _ode_matsol1() {_reset=0;{
double b_flux, f_flux, _term; int _i;
b_flux = f_flux = 0.;
{int _i; double _dt1 = 1.0/dt;
for(_i=0;_i<13;_i++){
_RHS1(_i) = _dt1*(_p[_dlist1[_i]]);
_MATELM1(_i, _i) = _dt1;
} }
rates ( _threadargscomma_ v ) ;
/* ~ C1 <-> C2 ( f01 , b01 )*/
_term = f01 ;
_MATELM1( 6 ,6) += _term;
_MATELM1( 5 ,6) -= _term;
_term = b01 ;
_MATELM1( 6 ,5) -= _term;
_MATELM1( 5 ,5) += _term;
/*REACTION*/
/* ~ C2 <-> C3 ( f02 , b02 )*/
_term = f02 ;
_MATELM1( 5 ,5) += _term;
_MATELM1( 4 ,5) -= _term;
_term = b02 ;
_MATELM1( 5 ,4) -= _term;
_MATELM1( 4 ,4) += _term;
/*REACTION*/
/* ~ C3 <-> C4 ( f03 , b03 )*/
_term = f03 ;
_MATELM1( 4 ,4) += _term;
_MATELM1( 3 ,4) -= _term;
_term = b03 ;
_MATELM1( 4 ,3) -= _term;
_MATELM1( 3 ,3) += _term;
/*REACTION*/
/* ~ C4 <-> C5 ( f04 , b04 )*/
_term = f04 ;
_MATELM1( 3 ,3) += _term;
_MATELM1( 2 ,3) -= _term;
_term = b04 ;
_MATELM1( 3 ,2) -= _term;
_MATELM1( 2 ,2) += _term;
/*REACTION*/
/* ~ C5 <-> O ( f0O , b0O )*/
_term = f0O ;
_MATELM1( 2 ,2) += _term;
_MATELM1( 12 ,2) -= _term;
_term = b0O ;
_MATELM1( 2 ,12) -= _term;
_MATELM1( 12 ,12) += _term;
/*REACTION*/
/* ~ O <-> B ( fip , bip )*/
_term = fip ;
_MATELM1( 12 ,12) += _term;
_MATELM1( 1 ,12) -= _term;
_term = bip ;
_MATELM1( 12 ,1) -= _term;
_MATELM1( 1 ,1) += _term;
/*REACTION*/
/* ~ O <-> I6 ( fin , bin )*/
_term = fin ;
_MATELM1( 12 ,12) += _term;
_MATELM1( 0 ,12) -= _term;
_term = bin ;
_MATELM1( 12 ,0) -= _term;
_MATELM1( 0 ,0) += _term;
/*REACTION*/
/* ~ I1 <-> I2 ( f11 , b11 )*/
_term = f11 ;
_MATELM1( 11 ,11) += _term;
_MATELM1( 10 ,11) -= _term;
_term = b11 ;
_MATELM1( 11 ,10) -= _term;
_MATELM1( 10 ,10) += _term;
/*REACTION*/
/* ~ I2 <-> I3 ( f12 , b12 )*/
_term = f12 ;
_MATELM1( 10 ,10) += _term;
_MATELM1( 9 ,10) -= _term;
_term = b12 ;
_MATELM1( 10 ,9) -= _term;
_MATELM1( 9 ,9) += _term;
/*REACTION*/
/* ~ I3 <-> I4 ( f13 , b13 )*/
_term = f13 ;
_MATELM1( 9 ,9) += _term;
_MATELM1( 8 ,9) -= _term;
_term = b13 ;
_MATELM1( 9 ,8) -= _term;
_MATELM1( 8 ,8) += _term;
/*REACTION*/
/* ~ I4 <-> I5 ( f14 , b14 )*/
_term = f14 ;
_MATELM1( 8 ,8) += _term;
_MATELM1( 7 ,8) -= _term;
_term = b14 ;
_MATELM1( 8 ,7) -= _term;
_MATELM1( 7 ,7) += _term;
/*REACTION*/
/* ~ I5 <-> I6 ( f1n , b1n )*/
_term = f1n ;
_MATELM1( 7 ,7) += _term;
_MATELM1( 0 ,7) -= _term;
_term = b1n ;
_MATELM1( 7 ,0) -= _term;
_MATELM1( 0 ,0) += _term;
/*REACTION*/
/* ~ C1 <-> I1 ( fi1 , bi1 )*/
_term = fi1 ;
_MATELM1( 6 ,6) += _term;
_MATELM1( 11 ,6) -= _term;
_term = bi1 ;
_MATELM1( 6 ,11) -= _term;
_MATELM1( 11 ,11) += _term;
/*REACTION*/
/* ~ C2 <-> I2 ( fi2 , bi2 )*/
_term = fi2 ;
_MATELM1( 5 ,5) += _term;
_MATELM1( 10 ,5) -= _term;
_term = bi2 ;
_MATELM1( 5 ,10) -= _term;
_MATELM1( 10 ,10) += _term;
/*REACTION*/
/* ~ C3 <-> I3 ( fi3 , bi3 )*/
_term = fi3 ;
_MATELM1( 4 ,4) += _term;
_MATELM1( 9 ,4) -= _term;
_term = bi3 ;
_MATELM1( 4 ,9) -= _term;
_MATELM1( 9 ,9) += _term;
/*REACTION*/
/* ~ C4 <-> I4 ( fi4 , bi4 )*/
_term = fi4 ;
_MATELM1( 3 ,3) += _term;
_MATELM1( 8 ,3) -= _term;
_term = bi4 ;
_MATELM1( 3 ,8) -= _term;
_MATELM1( 8 ,8) += _term;
/*REACTION*/
/* ~ C5 <-> I5 ( fi5 , bi5 )*/
_term = fi5 ;
_MATELM1( 2 ,2) += _term;
_MATELM1( 7 ,2) -= _term;
_term = bi5 ;
_MATELM1( 2 ,7) -= _term;
_MATELM1( 7 ,7) += _term;
/*REACTION*/
/* C1 + C2 + C3 + C4 + C5 + O + B + I1 + I2 + I3 + I4 + I5 + I6 = 1.0 */
/*CONSERVATION*/
} return _reset;
}
/*CVODE end*/
static int _ode_count(int _type){ return 13;}
static void _ode_spec(_NrnThread* _nt, _Memb_list* _ml, int _type) {
Datum* _thread;
Node* _nd; double _v; int _iml, _cntml;
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
_nd = _ml->_nodelist[_iml];
v = NODEV(_nd);
ena = _ion_ena;
_ode_spec1 ();
}}
static void _ode_map(int _ieq, double** _pv, double** _pvdot, double* _pp, Datum* _ppd, double* _atol, int _type) {
int _i; _p = _pp; _ppvar = _ppd;
_cvode_ieq = _ieq;
for (_i=0; _i < 13; ++_i) {
_pv[_i] = _pp + _slist1[_i]; _pvdot[_i] = _pp + _dlist1[_i];
_cvode_abstol(_atollist, _atol, _i);
}
}
static void _ode_matsol_instance1(_threadargsproto_) {
_cvode_sparse(&_cvsparseobj1, 13, _dlist1, _p, _ode_matsol1, &_coef1);
}
static void _ode_matsol(_NrnThread* _nt, _Memb_list* _ml, int _type) {
Datum* _thread;
Node* _nd; double _v; int _iml, _cntml;
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
_nd = _ml->_nodelist[_iml];
v = NODEV(_nd);
ena = _ion_ena;
_ode_matsol_instance1(_threadargs_);
}}
extern void nrn_update_ion_pointer(Symbol*, Datum*, int, int);
static void _update_ion_pointer(Datum* _ppvar) {
nrn_update_ion_pointer(_na_sym, _ppvar, 0, 0);
nrn_update_ion_pointer(_na_sym, _ppvar, 1, 3);
nrn_update_ion_pointer(_na_sym, _ppvar, 2, 4);
}
static void initmodel() {
int _i; double _save;_ninits++;
_save = t;
t = 0.0;
{
B = B0;
C5 = C50;
C4 = C40;
C3 = C30;
C2 = C20;
C1 = C10;
I6 = I60;
I5 = I50;
I4 = I40;
I3 = I30;
I2 = I20;
I1 = I10;
O = O0;
{
qt = pow( q10 , ( ( celsius - 22.0 ) / 10.0 ) ) ;
rates ( _threadargscomma_ v ) ;
error = 0; seqinitial();
error = simeq(13, _coef2, _p, _slist2);
if(error){fprintf(stderr,"at line 134 in file pc_Narsg.mod:\n SOLVE seqinitial\n"); nrn_complain(_p); abort_run(error);}
}
_sav_indep = t; t = _save;
}
}
static void nrn_init(_NrnThread* _nt, _Memb_list* _ml, int _type){
Node *_nd; double _v; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
v = _v;
ena = _ion_ena;
initmodel();
}}
static double _nrn_current(double _v){double _current=0.;v=_v;{ {
g = gbar * O ;
ina = g * ( v - ena ) ;
}
_current += ina;
} return _current;
}
static void nrn_cur(_NrnThread* _nt, _Memb_list* _ml, int _type){
Node *_nd; int* _ni; double _rhs, _v; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
ena = _ion_ena;
_g = _nrn_current(_v + .001);
{ double _dina;
_dina = ina;
_rhs = _nrn_current(_v);
_ion_dinadv += (_dina - ina)/.001 ;
}
_g = (_g - _rhs)/.001;
_ion_ina += ina ;
#if CACHEVEC
if (use_cachevec) {
VEC_RHS(_ni[_iml]) -= _rhs;
}else
#endif
{
NODERHS(_nd) -= _rhs;
}
}}
static void nrn_jacob(_NrnThread* _nt, _Memb_list* _ml, int _type){
Node *_nd; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml];
#if CACHEVEC
if (use_cachevec) {
VEC_D(_ni[_iml]) += _g;
}else
#endif
{
_nd = _ml->_nodelist[_iml];
NODED(_nd) += _g;
}
}}
static void nrn_state(_NrnThread* _nt, _Memb_list* _ml, int _type){
Node *_nd; double _v = 0.0; int* _ni; int _iml, _cntml;
double _dtsav = dt;
if (secondorder) { dt *= 0.5; }
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
_nd = _ml->_nodelist[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
v=_v;
{
ena = _ion_ena;
{ error = sparse(&_sparseobj1, 13, _slist1, _dlist1, _p, &t, dt, activation,&_coef1, _linmat1);
if(error){fprintf(stderr,"at line 126 in file pc_Narsg.mod:\n SOLVE activation METHOD sparse\n"); nrn_complain(_p); abort_run(error);}
if (secondorder) {
int _i;
for (_i = 0; _i < 13; ++_i) {
_p[_slist1[_i]] += dt*_p[_dlist1[_i]];
}}
} }}
dt = _dtsav;
}
static void terminal(){}
static void _initlists() {
int _i; static int _first = 1;
if (!_first) return;
_slist2[0] = &(I1) - _p;
_slist2[1] = &(C2) - _p;
_slist2[2] = &(C1) - _p;
_slist2[3] = &(I2) - _p;
_slist2[4] = &(C3) - _p;
_slist2[5] = &(I3) - _p;
_slist2[6] = &(C4) - _p;
_slist2[7] = &(I4) - _p;
_slist2[8] = &(C5) - _p;
_slist2[9] = &(I5) - _p;
_slist2[10] = &(O) - _p;
_slist2[11] = &(B) - _p;
_slist2[12] = &(I6) - _p;
if (_first) _coef2 = makematrix(13, 14);
_slist1[0] = &(I6) - _p; _dlist1[0] = &(DI6) - _p;
_slist1[1] = &(B) - _p; _dlist1[1] = &(DB) - _p;
_slist1[2] = &(C5) - _p; _dlist1[2] = &(DC5) - _p;
_slist1[3] = &(C4) - _p; _dlist1[3] = &(DC4) - _p;
_slist1[4] = &(C3) - _p; _dlist1[4] = &(DC3) - _p;
_slist1[5] = &(C2) - _p; _dlist1[5] = &(DC2) - _p;
_slist1[6] = &(C1) - _p; _dlist1[6] = &(DC1) - _p;
_slist1[7] = &(I5) - _p; _dlist1[7] = &(DI5) - _p;
_slist1[8] = &(I4) - _p; _dlist1[8] = &(DI4) - _p;
_slist1[9] = &(I3) - _p; _dlist1[9] = &(DI3) - _p;
_slist1[10] = &(I2) - _p; _dlist1[10] = &(DI2) - _p;
_slist1[11] = &(I1) - _p; _dlist1[11] = &(DI1) - _p;
_slist1[12] = &(O) - _p; _dlist1[12] = &(DO) - _p;
_first = 0;
}
#if NMODL_TEXT
static const char* nmodl_filename = "pc_Narsg.mod";
static const char* nmodl_file_text =
"TITLE resurgent sodium channel\n"
"\n"
"COMMENT\n"
"Neuron implementation of a resurgent sodium channel (with blocking particle)\n"
"Based om updated kinetic parameters from Raman and Bean, Biophys.J. 80 (2001) 729 \n"
"\n"
"Modified from Khaliq et al., J.Neurosci. 23(2003)4899\n"
"by qt-correction of all rate constants \n"
"\n"
"Laboratory for Neuronal Circuit Dynamics\n"
"RIKEN Brain Science Institute, Wako City, Japan\n"
"http://www.neurodynamics.brain.riken.jp\n"
"\n"
"Reference: Akemann and Knoepfel, J.Neurosci. 26 (2006) 4602\n"
"Date of Implementation: May 2005\n"
"Contact: akemann@brain.riken.jp\n"
"\n"
"ENDCOMMENT\n"
"\n"
"NEURON {\n"
" SUFFIX pcNarsg\n"
" USEION na READ ena WRITE ina\n"
" RANGE g, gbar, ina\n"
"\n"
"}\n"
"\n"
"UNITS { \n"
" (mV) = (millivolt)\n"
" (S) = (siemens)\n"
"}\n"
"\n"
"CONSTANT {\n"
" q10 = 2.2\n"
"}\n"
"\n"
"PARAMETER {\n"
" gbar = 0.016 (S/cm2)\n"
" celsius (degC)\n"
"\n"
" : kinetic parameters\n"
" Con = 0.005 (/ms) : closed -> inactivated transitions\n"
" Coff = 0.5 (/ms) : inactivated -> closed transitions\n"
" Oon = 0.75 (/ms) : open -> Ineg transition\n"
" Ooff = 0.005 (/ms) : Ineg -> open transition\n"
" alpha = 150 (/ms) : activation\n"
" beta = 3 (/ms) : deactivation\n"
" gamma = 150 (/ms) : opening\n"
" delta = 40 (/ms) : closing, greater than BEAN/KUO = 0.2\n"
" epsilon = 1.75 (/ms) : open -> Iplus for tau = 0.3 ms at +30 with x5\n"
" zeta = 0.03 (/ms) : Iplus -> open for tau = 25 ms at -30 with x6\n"
"\n"
" : Vdep\n"
" x1 = 20 (mV) : Vdep of activation (alpha)\n"
" x2 = -20 (mV) : Vdep of deactivation (beta)\n"
" x3 = 1e12 (mV) : Vdep of opening (gamma)\n"
" x4 = -1e12 (mV) : Vdep of closing (delta)\n"
" x5 = 1e12 (mV) : Vdep into Ipos (epsilon)\n"
" x6 = -25 (mV) : Vdep out of Ipos (zeta)\n"
"}\n"
"\n"
"ASSIGNED {\n"
" alfac : microscopic reversibility factors\n"
" btfac \n"
"\n"
" : rates\n"
" f01 (/ms)\n"
" f02 (/ms)\n"
" f03 (/ms)\n"
" f04 (/ms)\n"
" f0O (/ms)\n"
" fip (/ms)\n"
" f11 (/ms)\n"
" f12 (/ms)\n"
" f13 (/ms)\n"
" f14 (/ms)\n"
" f1n (/ms)\n"
" fi1 (/ms)\n"
" fi2 (/ms)\n"
" fi3 (/ms)\n"
" fi4 (/ms)\n"
" fi5 (/ms)\n"
" fin (/ms)\n"
"\n"
" b01 (/ms)\n"
" b02 (/ms)\n"
" b03 (/ms)\n"
" b04 (/ms)\n"
" b0O (/ms)\n"
" bip (/ms)\n"
" b11 (/ms)\n"
" b12 (/ms)\n"
" b13 (/ms)\n"
" b14 (/ms)\n"
" b1n (/ms)\n"
" bi1 (/ms)\n"
" bi2 (/ms)\n"
" bi3 (/ms)\n"
" bi4 (/ms)\n"
" bi5 (/ms)\n"
" bin (/ms)\n"
" \n"
" v (mV)\n"
" ena (mV)\n"
" ina (milliamp/cm2)\n"
" g (S/cm2)\n"
" qt\n"
"}\n"
"\n"
"STATE {\n"
" C1 FROM 0 TO 1\n"
" C2 FROM 0 TO 1\n"
" C3 FROM 0 TO 1\n"
" C4 FROM 0 TO 1\n"
" C5 FROM 0 TO 1\n"
" I1 FROM 0 TO 1\n"
" I2 FROM 0 TO 1\n"
" I3 FROM 0 TO 1\n"
" I4 FROM 0 TO 1\n"
" I5 FROM 0 TO 1\n"
" O FROM 0 TO 1\n"
" B FROM 0 TO 1\n"
" I6 FROM 0 TO 1\n"
"}\n"
"\n"
"BREAKPOINT {\n"
" SOLVE activation METHOD sparse\n"
" g = gbar * O\n"
" ina = g * (v - ena)\n"
"}\n"
"\n"
"INITIAL {\n"
" qt = q10^((celsius-22 (degC))/10 (degC))\n"
" rates(v)\n"
" SOLVE seqinitial\n"
"}\n"
"\n"
"KINETIC activation\n"
"{\n"
" rates(v)\n"
" ~ C1 <-> C2 (f01,b01)\n"
" ~ C2 <-> C3 (f02,b02)\n"
" ~ C3 <-> C4 (f03,b03)\n"
" ~ C4 <-> C5 (f04,b04)\n"
" ~ C5 <-> O (f0O,b0O)\n"
" ~ O <-> B (fip,bip)\n"
" ~ O <-> I6 (fin,bin)\n"
" ~ I1 <-> I2 (f11,b11)\n"
" ~ I2 <-> I3 (f12,b12)\n"
" ~ I3 <-> I4 (f13,b13)\n"
" ~ I4 <-> I5 (f14,b14)\n"
" ~ I5 <-> I6 (f1n,b1n)\n"
" ~ C1 <-> I1 (fi1,bi1)\n"
" ~ C2 <-> I2 (fi2,bi2)\n"
" ~ C3 <-> I3 (fi3,bi3)\n"
" ~ C4 <-> I4 (fi4,bi4)\n"
" ~ C5 <-> I5 (fi5,bi5)\n"
"\n"
"CONSERVE C1 + C2 + C3 + C4 + C5 + O + B + I1 + I2 + I3 + I4 + I5 + I6 = 1\n"
"}\n"
"\n"
"LINEAR seqinitial { : sets initial equilibrium\n"
" ~ I1*bi1 + C2*b01 - C1*( fi1+f01) = 0\n"
" ~ C1*f01 + I2*bi2 + C3*b02 - C2*(b01+fi2+f02) = 0\n"
" ~ C2*f02 + I3*bi3 + C4*b03 - C3*(b02+fi3+f03) = 0\n"
" ~ C3*f03 + I4*bi4 + C5*b04 - C4*(b03+fi4+f04) = 0\n"
" ~ C4*f04 + I5*bi5 + O*b0O - C5*(b04+fi5+f0O) = 0\n"
" ~ C5*f0O + B*bip + I6*bin - O*(b0O+fip+fin) = 0\n"
" ~ O*fip - B*bip = 0\n"
"\n"
" ~ C1*fi1 + I2*b11 - I1*( bi1+f11) = 0\n"
" ~ I1*f11 + C2*fi2 + I3*b12 - I2*(b11+bi2+f12) = 0\n"
" ~ I2*f12 + C3*fi3 + I4*bi3 - I3*(b12+bi3+f13) = 0\n"
" ~ I3*f13 + C4*fi4 + I5*b14 - I4*(b13+bi4+f14) = 0\n"
" ~ I4*f14 + C5*fi5 + I6*b1n - I5*(b14+bi5+f1n) = 0\n"
" \n"
" ~ C1 + C2 + C3 + C4 + C5 + O + B + I1 + I2 + I3 + I4 + I5 + I6 = 1\n"
"}\n"
"\n"
"PROCEDURE rates(v(mV) )\n"
"{\n"
" alfac = (Oon/Con)^(1/4)\n"
" btfac = (Ooff/Coff)^(1/4) \n"
" f01 = 4 * alpha * exp(v/x1) * qt\n"
" f02 = 3 * alpha * exp(v/x1) * qt\n"
" f03 = 2 * alpha * exp(v/x1) * qt\n"
" f04 = 1 * alpha * exp(v/x1) * qt\n"
" f0O = gamma * exp(v/x3) * qt\n"
" fip = epsilon * exp(v/x5) * qt\n"
" f11 = 4 * alpha * alfac * exp(v/x1) * qt\n"
" f12 = 3 * alpha * alfac * exp(v/x1) * qt\n"
" f13 = 2 * alpha * alfac * exp(v/x1) * qt\n"
" f14 = 1 * alpha * alfac * exp(v/x1) * qt\n"
" f1n = gamma * exp(v/x3) * qt\n"
" fi1 = Con * qt\n"
" fi2 = Con * alfac * qt\n"
" fi3 = Con * alfac^2 * qt\n"
" fi4 = Con * alfac^3 * qt\n"
" fi5 = Con * alfac^4 * qt\n"
" fin = Oon * qt\n"
"\n"
" b01 = 1 * beta * exp(v/x2) * qt\n"
" b02 = 2 * beta * exp(v/x2) * qt\n"
" b03 = 3 * beta * exp(v/x2) * qt\n"
" b04 = 4 * beta * exp(v/x2) * qt\n"
" b0O = delta * exp(v/x4) * qt\n"
" bip = zeta * exp(v/x6) * qt\n"
" b11 = 1 * beta * btfac * exp(v/x2) * qt\n"
" b12 = 2 * beta * btfac * exp(v/x2) * qt\n"
" b13 = 3 * beta * btfac * exp(v/x2) * qt\n"
" b14 = 4 * beta * btfac * exp(v/x2) * qt\n"
" b1n = delta * exp(v/x4) * qt\n"
" bi1 = Coff * qt\n"
" bi2 = Coff * btfac * qt\n"
" bi3 = Coff * btfac^2 * qt\n"
" bi4 = Coff * btfac^3 * qt\n"
" bi5 = Coff * btfac^4 * qt\n"
" bin = Ooff * qt\n"
"}\n"
"\n"
;
#endif