/* Created by Language version: 7.7.0 */
/* VECTORIZED */
#define NRN_VECTORIZED 1
#include <stdio.h>
#include <stdlib.h>
#include <math.h>
#include "scoplib_ansi.h"
#undef PI
#define nil 0
#include "md1redef.h"
#include "section.h"
#include "nrniv_mf.h"
#include "md2redef.h"
#if METHOD3
extern int _method3;
#endif
#if !NRNGPU
#undef exp
#define exp hoc_Exp
extern double hoc_Exp(double);
#endif
#define nrn_init _nrn_init__tcCaT
#define _nrn_initial _nrn_initial__tcCaT
#define nrn_cur _nrn_cur__tcCaT
#define _nrn_current _nrn_current__tcCaT
#define nrn_jacob _nrn_jacob__tcCaT
#define nrn_state _nrn_state__tcCaT
#define _net_receive _net_receive__tcCaT
#define rates rates__tcCaT
#define states states__tcCaT
#define _threadargscomma_ _p, _ppvar, _thread, _nt,
#define _threadargsprotocomma_ double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt,
#define _threadargs_ _p, _ppvar, _thread, _nt
#define _threadargsproto_ double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt
/*SUPPRESS 761*/
/*SUPPRESS 762*/
/*SUPPRESS 763*/
/*SUPPRESS 765*/
extern double *getarg();
/* Thread safe. No static _p or _ppvar. */
#define t _nt->_t
#define dt _nt->_dt
#define pca _p[0]
#define ica _p[1]
#define minf _p[2]
#define taum _p[3]
#define hinf _p[4]
#define tauh _p[5]
#define m_t _p[6]
#define h_t _p[7]
#define cao _p[8]
#define Dm_t _p[9]
#define Dh_t _p[10]
#define cai _p[11]
#define v _p[12]
#define _g _p[13]
#define _ion_cai *_ppvar[0]._pval
#define _ion_cao *_ppvar[1]._pval
#define _ion_ica *_ppvar[2]._pval
#define _ion_dicadv *_ppvar[3]._pval
#if MAC
#if !defined(v)
#define v _mlhv
#endif
#if !defined(h)
#define h _mlhh
#endif
#endif
#if defined(__cplusplus)
extern "C" {
#endif
static int hoc_nrnpointerindex = -1;
static Datum* _extcall_thread;
static Prop* _extcall_prop;
/* external NEURON variables */
/* declaration of user functions */
static void _hoc_efun(void);
static void _hoc_ghk(void);
static void _hoc_rates(void);
static int _mechtype;
extern void _nrn_cacheloop_reg(int, int);
extern void hoc_register_prop_size(int, int, int);
extern void hoc_register_limits(int, HocParmLimits*);
extern void hoc_register_units(int, HocParmUnits*);
extern void nrn_promote(Prop*, int, int);
extern Memb_func* memb_func;
#define NMODL_TEXT 1
#if NMODL_TEXT
static const char* nmodl_file_text;
static const char* nmodl_filename;
extern void hoc_reg_nmodl_text(int, const char*);
extern void hoc_reg_nmodl_filename(int, const char*);
#endif
extern void _nrn_setdata_reg(int, void(*)(Prop*));
static void _setdata(Prop* _prop) {
_extcall_prop = _prop;
}
static void _hoc_setdata() {
Prop *_prop, *hoc_getdata_range(int);
_prop = hoc_getdata_range(_mechtype);
_setdata(_prop);
hoc_retpushx(1.);
}
/* connect user functions to hoc names */
static VoidFunc hoc_intfunc[] = {
"setdata_tcCaT", _hoc_setdata,
"efun_tcCaT", _hoc_efun,
"ghk_tcCaT", _hoc_ghk,
"rates_tcCaT", _hoc_rates,
0, 0
};
#define efun efun_tcCaT
#define ghk ghk_tcCaT
extern double efun( _threadargsprotocomma_ double );
extern double ghk( _threadargsprotocomma_ double , double , double );
/* declare global and static user variables */
#define dpt dpt_tcCaT
double dpt = 1;
#define kca kca_tcCaT
double kca = 5.1821e-005;
#define tau_ca tau_ca_tcCaT
double tau_ca = 5;
/* some parameters have upper and lower limits */
static HocParmLimits _hoc_parm_limits[] = {
0,0,0
};
static HocParmUnits _hoc_parm_units[] = {
"dpt_tcCaT", "um",
"tau_ca_tcCaT", "ms",
"pca_tcCaT", "cm/s",
"ica_tcCaT", "mA/cm2",
"taum_tcCaT", "ms",
"tauh_tcCaT", "ms",
0,0
};
static double delta_t = 0.01;
static double h_t0 = 0;
static double m_t0 = 0;
/* connect global user variables to hoc */
static DoubScal hoc_scdoub[] = {
"dpt_tcCaT", &dpt_tcCaT,
"tau_ca_tcCaT", &tau_ca_tcCaT,
"kca_tcCaT", &kca_tcCaT,
0,0
};
static DoubVec hoc_vdoub[] = {
0,0,0
};
static double _sav_indep;
static void nrn_alloc(Prop*);
static void nrn_init(_NrnThread*, _Memb_list*, int);
static void nrn_state(_NrnThread*, _Memb_list*, int);
static void nrn_cur(_NrnThread*, _Memb_list*, int);
static void nrn_jacob(_NrnThread*, _Memb_list*, int);
static int _ode_count(int);
static void _ode_map(int, double**, double**, double*, Datum*, double*, int);
static void _ode_spec(_NrnThread*, _Memb_list*, int);
static void _ode_matsol(_NrnThread*, _Memb_list*, int);
#define _cvode_ieq _ppvar[4]._i
static void _ode_matsol_instance1(_threadargsproto_);
/* connect range variables in _p that hoc is supposed to know about */
static const char *_mechanism[] = {
"7.7.0",
"tcCaT",
"pca_tcCaT",
0,
"ica_tcCaT",
"minf_tcCaT",
"taum_tcCaT",
"hinf_tcCaT",
"tauh_tcCaT",
0,
"m_t_tcCaT",
"h_t_tcCaT",
0,
0};
static Symbol* _ca_sym;
extern Prop* need_memb(Symbol*);
static void nrn_alloc(Prop* _prop) {
Prop *prop_ion;
double *_p; Datum *_ppvar;
_p = nrn_prop_data_alloc(_mechtype, 14, _prop);
/*initialize range parameters*/
pca = 0.0001;
_prop->param = _p;
_prop->param_size = 14;
_ppvar = nrn_prop_datum_alloc(_mechtype, 5, _prop);
_prop->dparam = _ppvar;
/*connect ionic variables to this model*/
prop_ion = need_memb(_ca_sym);
nrn_promote(prop_ion, 1, 0);
_ppvar[0]._pval = &prop_ion->param[1]; /* cai */
_ppvar[1]._pval = &prop_ion->param[2]; /* cao */
_ppvar[2]._pval = &prop_ion->param[3]; /* ica */
_ppvar[3]._pval = &prop_ion->param[4]; /* _ion_dicadv */
}
static void _initlists();
/* some states have an absolute tolerance */
static Symbol** _atollist;
static HocStateTolerance _hoc_state_tol[] = {
0,0
};
static void _update_ion_pointer(Datum*);
extern Symbol* hoc_lookup(const char*);
extern void _nrn_thread_reg(int, int, void(*)(Datum*));
extern void _nrn_thread_table_reg(int, void(*)(double*, Datum*, Datum*, _NrnThread*, int));
extern void hoc_register_tolerance(int, HocStateTolerance*, Symbol***);
extern void _cvode_abstol( Symbol**, double*, int);
void _tc_CaT_reg() {
int _vectorized = 1;
_initlists();
ion_reg("ca", -10000.);
_ca_sym = hoc_lookup("ca_ion");
register_mech(_mechanism, nrn_alloc,nrn_cur, nrn_jacob, nrn_state, nrn_init, hoc_nrnpointerindex, 1);
_mechtype = nrn_get_mechtype(_mechanism[1]);
_nrn_setdata_reg(_mechtype, _setdata);
_nrn_thread_reg(_mechtype, 2, _update_ion_pointer);
#if NMODL_TEXT
hoc_reg_nmodl_text(_mechtype, nmodl_file_text);
hoc_reg_nmodl_filename(_mechtype, nmodl_filename);
#endif
hoc_register_prop_size(_mechtype, 14, 5);
hoc_register_dparam_semantics(_mechtype, 0, "ca_ion");
hoc_register_dparam_semantics(_mechtype, 1, "ca_ion");
hoc_register_dparam_semantics(_mechtype, 2, "ca_ion");
hoc_register_dparam_semantics(_mechtype, 3, "ca_ion");
hoc_register_dparam_semantics(_mechtype, 4, "cvodeieq");
hoc_register_cvode(_mechtype, _ode_count, _ode_map, _ode_spec, _ode_matsol);
hoc_register_tolerance(_mechtype, _hoc_state_tol, &_atollist);
hoc_register_var(hoc_scdoub, hoc_vdoub, hoc_intfunc);
ivoc_help("help ?1 tcCaT D:/Projects/SchreglmannEtAl2020/CCTC_model/modfiles/tc_CaT.mod\n");
hoc_register_limits(_mechtype, _hoc_parm_limits);
hoc_register_units(_mechtype, _hoc_parm_units);
}
static double FARADAY = 96485.3;
static double R = 8.3145;
static int _reset;
static char *modelname = "Thalamocortical neuron T-type calcium channel";
static int error;
static int _ninits = 0;
static int _match_recurse=1;
static void _modl_cleanup(){ _match_recurse=1;}
static int rates(_threadargsprotocomma_ double);
static int _ode_spec1(_threadargsproto_);
/*static int _ode_matsol1(_threadargsproto_);*/
static int _slist1[2], _dlist1[2];
static int states(_threadargsproto_);
/*CVODE*/
static int _ode_spec1 (double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt) {int _reset = 0; {
rates ( _threadargscomma_ v ) ;
Dm_t = ( minf - m_t ) / taum ;
Dh_t = ( hinf - h_t ) / tauh ;
}
return _reset;
}
static int _ode_matsol1 (double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt) {
rates ( _threadargscomma_ v ) ;
Dm_t = Dm_t / (1. - dt*( ( ( ( - 1.0 ) ) ) / taum )) ;
Dh_t = Dh_t / (1. - dt*( ( ( ( - 1.0 ) ) ) / tauh )) ;
return 0;
}
/*END CVODE*/
static int states (double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt) { {
rates ( _threadargscomma_ v ) ;
m_t = m_t + (1. - exp(dt*(( ( ( - 1.0 ) ) ) / taum)))*(- ( ( ( minf ) ) / taum ) / ( ( ( ( - 1.0 ) ) ) / taum ) - m_t) ;
h_t = h_t + (1. - exp(dt*(( ( ( - 1.0 ) ) ) / tauh)))*(- ( ( ( hinf ) ) / tauh ) / ( ( ( ( - 1.0 ) ) ) / tauh ) - h_t) ;
}
return 0;
}
static int rates ( _threadargsprotocomma_ double _lv ) {
minf = 1.0 / ( 1.0 + exp ( - ( _lv + 60.0 ) / 6.2 ) ) ;
taum = 0.204 + 0.333 / ( exp ( - ( _lv + 136.0 ) / 16.7 ) + exp ( ( _lv + 19.8 ) / 18.2 ) ) ;
hinf = 1.0 / ( 1.0 + exp ( ( _lv + 84.0 ) / 4.0 ) ) ;
if ( _lv >= - 81.0 ) {
tauh = 9.33 + 0.333 * exp ( - ( _lv + 25.0 ) / 10.5 ) ;
}
else {
tauh = 0.333 * exp ( ( _lv + 470.0 ) / 66.6 ) ;
}
return 0; }
static void _hoc_rates(void) {
double _r;
double* _p; Datum* _ppvar; Datum* _thread; _NrnThread* _nt;
if (_extcall_prop) {_p = _extcall_prop->param; _ppvar = _extcall_prop->dparam;}else{ _p = (double*)0; _ppvar = (Datum*)0; }
_thread = _extcall_thread;
_nt = nrn_threads;
_r = 1.;
rates ( _p, _ppvar, _thread, _nt, *getarg(1) );
hoc_retpushx(_r);
}
double ghk ( _threadargsprotocomma_ double _lv , double _lci , double _lco ) {
double _lghk;
double _lz , _leci , _leco ;
_lz = ( 1e-3 ) * 2.0 * FARADAY * _lv / ( R * ( 36.0 + 273.15 ) ) ;
_leco = _lco * efun ( _threadargscomma_ _lz ) ;
_leci = _lci * efun ( _threadargscomma_ - _lz ) ;
_lghk = ( .001 ) * 2.0 * FARADAY * ( _leci - _leco ) ;
return _lghk;
}
static void _hoc_ghk(void) {
double _r;
double* _p; Datum* _ppvar; Datum* _thread; _NrnThread* _nt;
if (_extcall_prop) {_p = _extcall_prop->param; _ppvar = _extcall_prop->dparam;}else{ _p = (double*)0; _ppvar = (Datum*)0; }
_thread = _extcall_thread;
_nt = nrn_threads;
_r = ghk ( _p, _ppvar, _thread, _nt, *getarg(1) , *getarg(2) , *getarg(3) );
hoc_retpushx(_r);
}
double efun ( _threadargsprotocomma_ double _lz ) {
double _lefun;
if ( fabs ( _lz ) < 1e-4 ) {
_lefun = 1.0 - _lz / 2.0 ;
}
else {
_lefun = _lz / ( exp ( _lz ) - 1.0 ) ;
}
return _lefun;
}
static void _hoc_efun(void) {
double _r;
double* _p; Datum* _ppvar; Datum* _thread; _NrnThread* _nt;
if (_extcall_prop) {_p = _extcall_prop->param; _ppvar = _extcall_prop->dparam;}else{ _p = (double*)0; _ppvar = (Datum*)0; }
_thread = _extcall_thread;
_nt = nrn_threads;
_r = efun ( _p, _ppvar, _thread, _nt, *getarg(1) );
hoc_retpushx(_r);
}
static int _ode_count(int _type){ return 2;}
static void _ode_spec(_NrnThread* _nt, _Memb_list* _ml, int _type) {
double* _p; Datum* _ppvar; Datum* _thread;
Node* _nd; double _v; int _iml, _cntml;
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
_nd = _ml->_nodelist[_iml];
v = NODEV(_nd);
cai = _ion_cai;
cao = _ion_cao;
_ode_spec1 (_p, _ppvar, _thread, _nt);
}}
static void _ode_map(int _ieq, double** _pv, double** _pvdot, double* _pp, Datum* _ppd, double* _atol, int _type) {
double* _p; Datum* _ppvar;
int _i; _p = _pp; _ppvar = _ppd;
_cvode_ieq = _ieq;
for (_i=0; _i < 2; ++_i) {
_pv[_i] = _pp + _slist1[_i]; _pvdot[_i] = _pp + _dlist1[_i];
_cvode_abstol(_atollist, _atol, _i);
}
}
static void _ode_matsol_instance1(_threadargsproto_) {
_ode_matsol1 (_p, _ppvar, _thread, _nt);
}
static void _ode_matsol(_NrnThread* _nt, _Memb_list* _ml, int _type) {
double* _p; Datum* _ppvar; Datum* _thread;
Node* _nd; double _v; int _iml, _cntml;
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
_nd = _ml->_nodelist[_iml];
v = NODEV(_nd);
cai = _ion_cai;
cao = _ion_cao;
_ode_matsol_instance1(_threadargs_);
}}
extern void nrn_update_ion_pointer(Symbol*, Datum*, int, int);
static void _update_ion_pointer(Datum* _ppvar) {
nrn_update_ion_pointer(_ca_sym, _ppvar, 0, 1);
nrn_update_ion_pointer(_ca_sym, _ppvar, 1, 2);
nrn_update_ion_pointer(_ca_sym, _ppvar, 2, 3);
nrn_update_ion_pointer(_ca_sym, _ppvar, 3, 4);
}
static void initmodel(double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt) {
int _i; double _save;{
h_t = h_t0;
m_t = m_t0;
{
m_t = 0.0 ;
h_t = 0.0 ;
}
}
}
static void nrn_init(_NrnThread* _nt, _Memb_list* _ml, int _type){
double* _p; Datum* _ppvar; Datum* _thread;
Node *_nd; double _v; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
v = _v;
cai = _ion_cai;
cao = _ion_cao;
initmodel(_p, _ppvar, _thread, _nt);
}
}
static double _nrn_current(double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt, double _v){double _current=0.;v=_v;{ {
ica = pca * ( pow( m_t , 2.0 ) ) * h_t * ghk ( _threadargscomma_ v , cai , cao ) ;
}
_current += ica;
} return _current;
}
static void nrn_cur(_NrnThread* _nt, _Memb_list* _ml, int _type) {
double* _p; Datum* _ppvar; Datum* _thread;
Node *_nd; int* _ni; double _rhs, _v; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
cai = _ion_cai;
cao = _ion_cao;
_g = _nrn_current(_p, _ppvar, _thread, _nt, _v + .001);
{ double _dica;
_dica = ica;
_rhs = _nrn_current(_p, _ppvar, _thread, _nt, _v);
_ion_dicadv += (_dica - ica)/.001 ;
}
_g = (_g - _rhs)/.001;
_ion_ica += ica ;
#if CACHEVEC
if (use_cachevec) {
VEC_RHS(_ni[_iml]) -= _rhs;
}else
#endif
{
NODERHS(_nd) -= _rhs;
}
}
}
static void nrn_jacob(_NrnThread* _nt, _Memb_list* _ml, int _type) {
double* _p; Datum* _ppvar; Datum* _thread;
Node *_nd; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml];
#if CACHEVEC
if (use_cachevec) {
VEC_D(_ni[_iml]) += _g;
}else
#endif
{
_nd = _ml->_nodelist[_iml];
NODED(_nd) += _g;
}
}
}
static void nrn_state(_NrnThread* _nt, _Memb_list* _ml, int _type) {
double* _p; Datum* _ppvar; Datum* _thread;
Node *_nd; double _v = 0.0; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
_nd = _ml->_nodelist[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
v=_v;
{
cai = _ion_cai;
cao = _ion_cao;
{ states(_p, _ppvar, _thread, _nt);
} }}
}
static void terminal(){}
static void _initlists(){
double _x; double* _p = &_x;
int _i; static int _first = 1;
if (!_first) return;
_slist1[0] = &(m_t) - _p; _dlist1[0] = &(Dm_t) - _p;
_slist1[1] = &(h_t) - _p; _dlist1[1] = &(Dh_t) - _p;
_first = 0;
}
#if defined(__cplusplus)
} /* extern "C" */
#endif
#if NMODL_TEXT
static const char* nmodl_filename = "tc_CaT.mod";
static const char* nmodl_file_text =
"TITLE Thalamocortical neuron T-type calcium channel\n"
"\n"
"COMMENT\n"
"\n"
" T-type calcium channel\n"
" Implementation of Meijer et al., 2011\n"
" Written by Xu Zhang, UConn, 2018\n"
"\n"
"ENDCOMMENT\n"
"\n"
"NEURON {\n"
" SUFFIX tcCaT\n"
" USEION ca READ cai, cao WRITE ica\n"
" RANGE pca, m_t, minf, taum, h_t, hinf, tauh, cai, pump, ica\n"
"}\n"
"\n"
"UNITS {\n"
" (molar) = (1/liter)\n"
" (mV) = (millivolt)\n"
" (mA) = (milliamp)\n"
" (mM) = (millimolar)\n"
" (um) = (micron)\n"
" FARADAY = (faraday) (coulomb)\n"
" R = (k-mole) (joule/degC)\n"
"}\n"
"\n"
"PARAMETER {\n"
" v (mV)\n"
" pca = 1e-4 (cm/s)\n"
" cao = 2 (mM)\n"
" dpt = 1.0 (um)\n"
" tau_ca = 5.0 (ms)\n"
" kca = 5.1821e-5\n"
"}\n"
"\n"
"STATE {\n"
" m_t\n"
" h_t\n"
"}\n"
"\n"
"ASSIGNED {\n"
" ica (mA/cm2)\n"
" cai (mM)\n"
" minf\n"
" taum (ms)\n"
" hinf\n"
" tauh (ms)\n"
"}\n"
"\n"
"BREAKPOINT {\n"
" SOLVE states METHOD cnexp\n"
" \n"
" ica = pca*(m_t^2)*h_t*ghk(v,cai,cao)\n"
"}\n"
"\n"
"DERIVATIVE states {\n"
" rates(v)\n"
" m_t' = (minf-m_t)/taum \n"
" h_t' = (hinf-h_t)/tauh\n"
"}\n"
"\n"
"INITIAL {\n"
" m_t = 0\n"
" h_t = 0\n"
" :cai = cabuf\n"
"}\n"
"\n"
"PROCEDURE rates(v (mV)) {\n"
" minf = 1/(1+exp(-(v+60)/6.2))\n"
" taum = 0.204+0.333/(exp(-(v+136)/16.7)+exp((v+19.8)/18.2))\n"
" \n"
" hinf = 1/(1+exp((v+84)/4))\n"
" if (v>=-81) {\n"
" tauh = 9.33+0.333*exp(-(v+25)/10.5)\n"
" } else {\n"
" tauh = 0.333*exp((v+470)/66.6)\n"
" }\n"
"}\n"
"\n"
"FUNCTION ghk(v(mV), ci(mM), co(mM)) (.001 coul/cm3) {\n"
" LOCAL z, eci, eco\n"
" z = (1e-3)*2*FARADAY*v/(R*(36+273.15))\n"
" eco = co*efun(z)\n"
" eci = ci*efun(-z)\n"
" :high cao charge moves inward\n"
" :negative potential charge moves inward\n"
" ghk = (.001)*2*FARADAY*(eci - eco)\n"
"}\n"
"\n"
"FUNCTION efun(z) {\n"
" if (fabs(z) < 1e-4) {\n"
" efun = 1 - z/2\n"
" }else{\n"
" efun = z/(exp(z) - 1)\n"
" }\n"
"}\n"
;
#endif