/* Created by Language version: 7.7.0 */
/* VECTORIZED */
#define NRN_VECTORIZED 1
#include <stdio.h>
#include <stdlib.h>
#include <math.h>
#include "scoplib_ansi.h"
#undef PI
#define nil 0
#include "md1redef.h"
#include "section.h"
#include "nrniv_mf.h"
#include "md2redef.h"
#if METHOD3
extern int _method3;
#endif
#if !NRNGPU
#undef exp
#define exp hoc_Exp
extern double hoc_Exp(double);
#endif
#define nrn_init _nrn_init__tcpas2
#define _nrn_initial _nrn_initial__tcpas2
#define nrn_cur _nrn_cur__tcpas2
#define _nrn_current _nrn_current__tcpas2
#define nrn_jacob _nrn_jacob__tcpas2
#define nrn_state _nrn_state__tcpas2
#define _net_receive _net_receive__tcpas2
#define _threadargscomma_ _p, _ppvar, _thread, _nt,
#define _threadargsprotocomma_ double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt,
#define _threadargs_ _p, _ppvar, _thread, _nt
#define _threadargsproto_ double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt
/*SUPPRESS 761*/
/*SUPPRESS 762*/
/*SUPPRESS 763*/
/*SUPPRESS 765*/
extern double *getarg();
/* Thread safe. No static _p or _ppvar. */
#define t _nt->_t
#define dt _nt->_dt
#define g_kl _p[0]
#define g_nl _p[1]
#define i _p[2]
#define ena _p[3]
#define ek _p[4]
#define ik _p[5]
#define ina _p[6]
#define v _p[7]
#define _g _p[8]
#define _ion_ena *_ppvar[0]._pval
#define _ion_ina *_ppvar[1]._pval
#define _ion_dinadv *_ppvar[2]._pval
#define _ion_ek *_ppvar[3]._pval
#define _ion_ik *_ppvar[4]._pval
#define _ion_dikdv *_ppvar[5]._pval
#if MAC
#if !defined(v)
#define v _mlhv
#endif
#if !defined(h)
#define h _mlhh
#endif
#endif
#if defined(__cplusplus)
extern "C" {
#endif
static int hoc_nrnpointerindex = -1;
static Datum* _extcall_thread;
static Prop* _extcall_prop;
/* external NEURON variables */
/* declaration of user functions */
static int _mechtype;
extern void _nrn_cacheloop_reg(int, int);
extern void hoc_register_prop_size(int, int, int);
extern void hoc_register_limits(int, HocParmLimits*);
extern void hoc_register_units(int, HocParmUnits*);
extern void nrn_promote(Prop*, int, int);
extern Memb_func* memb_func;
#define NMODL_TEXT 1
#if NMODL_TEXT
static const char* nmodl_file_text;
static const char* nmodl_filename;
extern void hoc_reg_nmodl_text(int, const char*);
extern void hoc_reg_nmodl_filename(int, const char*);
#endif
extern void _nrn_setdata_reg(int, void(*)(Prop*));
static void _setdata(Prop* _prop) {
_extcall_prop = _prop;
}
static void _hoc_setdata() {
Prop *_prop, *hoc_getdata_range(int);
_prop = hoc_getdata_range(_mechtype);
_setdata(_prop);
hoc_retpushx(1.);
}
/* connect user functions to hoc names */
static VoidFunc hoc_intfunc[] = {
"setdata_tcpas2", _hoc_setdata,
0, 0
};
/* declare global and static user variables */
/* some parameters have upper and lower limits */
static HocParmLimits _hoc_parm_limits[] = {
0,0,0
};
static HocParmUnits _hoc_parm_units[] = {
"g_kl_tcpas2", "mho/cm2",
"g_nl_tcpas2", "mho/cm2",
"i_tcpas2", "mA/cm2",
0,0
};
/* connect global user variables to hoc */
static DoubScal hoc_scdoub[] = {
0,0
};
static DoubVec hoc_vdoub[] = {
0,0,0
};
static double _sav_indep;
static void nrn_alloc(Prop*);
static void nrn_init(_NrnThread*, _Memb_list*, int);
static void nrn_state(_NrnThread*, _Memb_list*, int);
static void nrn_cur(_NrnThread*, _Memb_list*, int);
static void nrn_jacob(_NrnThread*, _Memb_list*, int);
/* connect range variables in _p that hoc is supposed to know about */
static const char *_mechanism[] = {
"7.7.0",
"tcpas2",
"g_kl_tcpas2",
"g_nl_tcpas2",
0,
"i_tcpas2",
0,
0,
0};
static Symbol* _na_sym;
static Symbol* _k_sym;
extern Prop* need_memb(Symbol*);
static void nrn_alloc(Prop* _prop) {
Prop *prop_ion;
double *_p; Datum *_ppvar;
_p = nrn_prop_data_alloc(_mechtype, 9, _prop);
/*initialize range parameters*/
g_kl = 5e-005;
g_nl = 2e-005;
_prop->param = _p;
_prop->param_size = 9;
_ppvar = nrn_prop_datum_alloc(_mechtype, 6, _prop);
_prop->dparam = _ppvar;
/*connect ionic variables to this model*/
prop_ion = need_memb(_na_sym);
nrn_promote(prop_ion, 0, 1);
_ppvar[0]._pval = &prop_ion->param[0]; /* ena */
_ppvar[1]._pval = &prop_ion->param[3]; /* ina */
_ppvar[2]._pval = &prop_ion->param[4]; /* _ion_dinadv */
prop_ion = need_memb(_k_sym);
nrn_promote(prop_ion, 0, 1);
_ppvar[3]._pval = &prop_ion->param[0]; /* ek */
_ppvar[4]._pval = &prop_ion->param[3]; /* ik */
_ppvar[5]._pval = &prop_ion->param[4]; /* _ion_dikdv */
}
static void _initlists();
static void _update_ion_pointer(Datum*);
extern Symbol* hoc_lookup(const char*);
extern void _nrn_thread_reg(int, int, void(*)(Datum*));
extern void _nrn_thread_table_reg(int, void(*)(double*, Datum*, Datum*, _NrnThread*, int));
extern void hoc_register_tolerance(int, HocStateTolerance*, Symbol***);
extern void _cvode_abstol( Symbol**, double*, int);
void _tc_pas2_reg() {
int _vectorized = 1;
_initlists();
ion_reg("na", -10000.);
ion_reg("k", -10000.);
_na_sym = hoc_lookup("na_ion");
_k_sym = hoc_lookup("k_ion");
register_mech(_mechanism, nrn_alloc,nrn_cur, nrn_jacob, nrn_state, nrn_init, hoc_nrnpointerindex, 1);
_mechtype = nrn_get_mechtype(_mechanism[1]);
_nrn_setdata_reg(_mechtype, _setdata);
_nrn_thread_reg(_mechtype, 2, _update_ion_pointer);
#if NMODL_TEXT
hoc_reg_nmodl_text(_mechtype, nmodl_file_text);
hoc_reg_nmodl_filename(_mechtype, nmodl_filename);
#endif
hoc_register_prop_size(_mechtype, 9, 6);
hoc_register_dparam_semantics(_mechtype, 0, "na_ion");
hoc_register_dparam_semantics(_mechtype, 1, "na_ion");
hoc_register_dparam_semantics(_mechtype, 2, "na_ion");
hoc_register_dparam_semantics(_mechtype, 3, "k_ion");
hoc_register_dparam_semantics(_mechtype, 4, "k_ion");
hoc_register_dparam_semantics(_mechtype, 5, "k_ion");
hoc_register_var(hoc_scdoub, hoc_vdoub, hoc_intfunc);
ivoc_help("help ?1 tcpas2 D:/Projects/SchreglmannEtAl2020/CCTC_model/modfiles/tc_pas2.mod\n");
hoc_register_limits(_mechtype, _hoc_parm_limits);
hoc_register_units(_mechtype, _hoc_parm_units);
}
static int _reset;
static char *modelname = "Thalamocortical neuron passive leakage channels";
static int error;
static int _ninits = 0;
static int _match_recurse=1;
static void _modl_cleanup(){ _match_recurse=1;}
extern void nrn_update_ion_pointer(Symbol*, Datum*, int, int);
static void _update_ion_pointer(Datum* _ppvar) {
nrn_update_ion_pointer(_na_sym, _ppvar, 0, 0);
nrn_update_ion_pointer(_na_sym, _ppvar, 1, 3);
nrn_update_ion_pointer(_na_sym, _ppvar, 2, 4);
nrn_update_ion_pointer(_k_sym, _ppvar, 3, 0);
nrn_update_ion_pointer(_k_sym, _ppvar, 4, 3);
nrn_update_ion_pointer(_k_sym, _ppvar, 5, 4);
}
static void initmodel(double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt) {
int _i; double _save;{
}
}
static void nrn_init(_NrnThread* _nt, _Memb_list* _ml, int _type){
double* _p; Datum* _ppvar; Datum* _thread;
Node *_nd; double _v; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
v = _v;
ena = _ion_ena;
ek = _ion_ek;
initmodel(_p, _ppvar, _thread, _nt);
}
}
static double _nrn_current(double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt, double _v){double _current=0.;v=_v;{ {
ik = g_kl * ( v - ek ) ;
ina = g_nl * ( v - ena ) ;
i = ik + ina ;
}
_current += ina;
_current += ik;
_current += i;
} return _current;
}
static void nrn_cur(_NrnThread* _nt, _Memb_list* _ml, int _type) {
double* _p; Datum* _ppvar; Datum* _thread;
Node *_nd; int* _ni; double _rhs, _v; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
ena = _ion_ena;
ek = _ion_ek;
_g = _nrn_current(_p, _ppvar, _thread, _nt, _v + .001);
{ double _dik;
double _dina;
_dina = ina;
_dik = ik;
_rhs = _nrn_current(_p, _ppvar, _thread, _nt, _v);
_ion_dinadv += (_dina - ina)/.001 ;
_ion_dikdv += (_dik - ik)/.001 ;
}
_g = (_g - _rhs)/.001;
_ion_ina += ina ;
_ion_ik += ik ;
#if CACHEVEC
if (use_cachevec) {
VEC_RHS(_ni[_iml]) -= _rhs;
}else
#endif
{
NODERHS(_nd) -= _rhs;
}
}
}
static void nrn_jacob(_NrnThread* _nt, _Memb_list* _ml, int _type) {
double* _p; Datum* _ppvar; Datum* _thread;
Node *_nd; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml];
#if CACHEVEC
if (use_cachevec) {
VEC_D(_ni[_iml]) += _g;
}else
#endif
{
_nd = _ml->_nodelist[_iml];
NODED(_nd) += _g;
}
}
}
static void nrn_state(_NrnThread* _nt, _Memb_list* _ml, int _type) {
}
static void terminal(){}
static void _initlists(){
double _x; double* _p = &_x;
int _i; static int _first = 1;
if (!_first) return;
_first = 0;
}
#if defined(__cplusplus)
} /* extern "C" */
#endif
#if NMODL_TEXT
static const char* nmodl_filename = "tc_pas2.mod";
static const char* nmodl_file_text =
"TITLE Thalamocortical neuron passive leakage channels\n"
"\n"
"COMMENT\n"
"\n"
" Leakage Na+ and K+ currents responsible for resting potential\n"
" Implementation of Meijer et al., 2011\n"
" Written by Xu Zhang, UConn, 2018\n"
" \n"
"ENDCOMMENT\n"
"\n"
"NEURON {\n"
" SUFFIX tcpas2\n"
" USEION na READ ena WRITE ina\n"
" USEION k READ ek WRITE ik\n"
" NONSPECIFIC_CURRENT i\n"
" RANGE g_kl, g_nl\n"
"}\n"
"\n"
"\n"
"UNITS {\n"
" (mV) = (millivolt)\n"
" (mA) = (milliamp)\n"
" (nA) = (nanoamp)\n"
" (pA) = (picoamp)\n"
" (S) = (siemens) \n"
"}\n"
"\n"
"PARAMETER {\n"
" g_kl = 5e-5 (mho/cm2)\n"
" g_nl = 2e-5 (mho/cm2)\n"
" ena = 45 (mV)\n"
" ek = -95 (mV)\n"
" v (mV)\n"
"}\n"
"\n"
"ASSIGNED {\n"
" i (mA/cm2)\n"
" ik (mA/cm2)\n"
" ina (mA/cm2)\n"
"}\n"
"\n"
"BREAKPOINT {\n"
" ik = g_kl * (v - ek)\n"
" ina = g_nl * (v - ena)\n"
" i = ik + ina\n"
"}\n"
;
#endif