COMMENT
A gap junction mechanism that is under blockade from GABAergic input
ENDCOMMENT
NEURON {
POINT_PROCESS iogap
POINTER vgap
RANGE tau1, tau2, g, i, noise
RANGE cc, maxblock
NONSPECIFIC_CURRENT i
}
UNITS {
(nA) = (nanoamp)
(mV) = (millivolt)
(uS) = (microsiemens)
}
PARAMETER {
tau1 = 60 (ms) <1e-9,1e9>
tau2 = 200 (ms) <1e-9,1e9>
g = 1.0 (uS)
noise = 0 (nA)
maxblock = 0.9
}
ASSIGNED {
i (nA)
v (millivolt)
vgap (millivolt)
factor
cc
}
STATE {
A (uS)
B (uS)
}
INITIAL {
LOCAL tp
cc = 1
A = 0
B = 0
tp = (tau1*tau2)/(tau2 - tau1) * log(tau2/tau1)
factor = -exp(-tp/tau1) + exp(-tp/tau2)
factor = 1/factor
}
BREAKPOINT {
SOLVE state METHOD cnexp
cc = 1 - maxblock*tanh(B - A)
i = g * cc * (v - vgap) + noise
}
DERIVATIVE state {
A' = -A/tau1
B' = -B/tau2
}
NET_RECEIVE(weight) {
A = A + weight*factor
B = B + weight*factor
}