TITLE Delayed rectifier potassium current in the interneuron soma
NEURON {
SUFFIX ikdrs
USEION k READ ek WRITE ik
RANGE gkdr, gk, ik
}
UNITS {
(molar) = (1/liter)
(mV) = (millivolt)
(mA) = (milliamp)
(mM) = (millimolar)
FARADAY = 96485.309 (coul/mole)
PI = (pi) (1)
}
INDEPENDENT {t FROM 0 TO 1 WITH 100 (ms)}
PARAMETER {
gkdr = 0.027 (mho/cm2)
}
ASSIGNED {
ik (mA/cm2)
v (mV)
ek (mV)
gk (mho/cm2)
}
STATE { n c }
BREAKPOINT {
SOLVE kstate METHOD sparse
gk = gkdr*n*n*n*n
ik = gk*(v-ek)
}
INITIAL {
n = n_inf(v)
c = 1-n
gk = gkdr*n*n*n*n
ik = gk*(v-ek)
}
LOCAL a1, a2
KINETIC kstate {
a1 = a_n(v)
a2 = a_c(v)
~ c <-> n (a1, a2)
CONSERVE n + c = 1
}
FUNCTION a_n(v(mV)) {
TABLE FROM -150 TO 150 WITH 200
a_n = n_inf(v)/tau_act(v)
}
FUNCTION a_c(v(mV)) {
TABLE FROM -150 TO 150 WITH 200
a_c = (1-n_inf(v))/tau_act(v)
}
FUNCTION n_inf(v(mV)) {
n_inf = 1/(1+exp((-4.8-v-37)/13.6))
}
FUNCTION tau_act(v(mV)) {
tau_act = 1.6/(0.0338338*exp(-v/40)+(0.016*exp(v/5)*(64.9+v))/(-0.00000230599+exp(v/5)))
}