TITLE Calcium-dependent K (afterhyperpolarization) current
NEURON {
SUFFIX kahp
USEION k READ ek WRITE ik
USEION ca READ cai
RANGE gkahp, ik, m
}
UNITS {
(molar) = (1/liter)
(mV) = (millivolt)
(mA) = (milliamp)
(mM) = (millimolar)
FARADAY = 96485.309 (coul/mole)
PI = (pi) (1)
}
INDEPENDENT {t FROM 0 TO 1 WITH 100 (ms)}
PARAMETER {
gkahp = 0.00005 (mho/cm2)
}
ASSIGNED {
ik (mA/cm2)
alpha (/ms)
beta (/ms)
v (mV)
ek (mV)
cai (mM)
}
STATE { m }
BREAKPOINT {
SOLVE states METHOD cnexp
ik = gkahp*m*(v-ek)
}
INITIAL {
rates(cai)
m = alpha/(alpha+beta)
ik = gkahp*m*(v-ek)
}
DERIVATIVE states {
rates(cai)
m' = alpha*(1-m)-beta*m
}
PROCEDURE rates(chi (mM)) {
if(cai<5e-5) {cai = 5e-5} :lower cai limit
if(cai<=5.5e-5) {
alpha = (cai-5e-5)*1e-2*2e5
} else {
alpha = 1e-2
}
beta = 1e-2
}