TITLE Fast Ca-dependent K current
NEURON {
SUFFIX kc
USEION k READ ek WRITE ik
USEION ca READ cai
RANGE gkc, ik, alpha, beta
}
UNITS {
(molar) = (1/liter)
(mV) = (millivolt)
(mA) = (milliamp)
(mM) = (millimolar)
FARADAY = 96485.309 (coul/mole)
PI = (pi) (1)
}
INDEPENDENT {t FROM 0 TO 1 WITH 100 (ms)}
PARAMETER {
gkc = 196 (mho/cm2)
}
ASSIGNED {
ik (mA/cm2)
alpha (/ms)
beta (/ms)
ek (mV)
v (mV)
cai (mM)
}
STATE { m }
BREAKPOINT {
SOLVE states METHOD cnexp
ik = gkc*min(cai/250(mM),1)*m*(v-ek)
}
INITIAL {
settables(v)
m = alpha/(alpha+beta)
ik = gkc*min(cai/250(mM),1)*m*(v-ek)
}
DERIVATIVE states {
settables(v)
m' = alpha*(1-m)-beta*m
}
PROCEDURE settables(v (mV)) {
TABLE alpha, beta FROM -120 TO 40 WITH 641
if(v<=-10.0) {
alpha = 1/18.975*(exp((v-10+60)/11-(v-6.5+60)/27))
beta = 2*exp((-v+6.5-60)/27)
} else {
alpha = 2*exp((-v+6.5-60)/27)
beta = 0
}
}
FUNCTION min(x,y) {
if(x<=y) {
min = x
} else {
min = y
}
}