TITLE Slowly activated voltage-dependent K current
NEURON {
SUFFIX km
USEION k READ ek WRITE ik
RANGE gkm, ik, alpha, beta
}
UNITS {
(molar) = (1/liter)
(mV) = (millivolt)
(mA) = (milliamp)
(mM) = (millimolar)
}
INDEPENDENT {t FROM 0 TO 1 WITH 100 (ms)}
PARAMETER {
gkm = 0.006 (mho/cm2)
}
ASSIGNED {
ik (mA/cm2)
alpha (/ms)
beta (/ms)
ek (mV)
v (mV)
}
STATE { m }
BREAKPOINT {
SOLVE states METHOD cnexp
ik = gkm*m*(v-ek)
}
INITIAL {
settables(v)
m = alpha/(alpha+beta)
ik = gkm*m*(v-ek)
}
DERIVATIVE states {
settables(v)
m' = alpha*(1-m)-beta*m
}
PROCEDURE settables(v (mV)) {
TABLE alpha, beta FROM -120 TO 40 WITH 641
alpha = m_inf(v)/tau_act(v)
beta = (1-m_inf(v))/tau_act(v)
}
FUNCTION m_inf(v(mV)) {
m_inf = 1/(1+exp(-(v+35-2)/5))
}
FUNCTION tau_act(v(mV)) {
tau_act = 1000/(3.3*exp((v+35)/40)+exp(-(v+35)/20))
}