COMMENT
Ih current - hyperpolarization-activated nonspecific Na and K channel
- contributes to the resting membrane potential
- controls the afterhyperpolarization
Conductance density is modified by Vlad as through database
Reference:
Saraga, F. (2003). Active dendrites and spike propagation in multi-compartment models of oriens-lacunosum/moleculare hippocampal interneurons. The Journal of physiology, 552(3), 673-689.
ENDCOMMENT
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
}
NEURON {
SUFFIX Ih
USEION h READ eh WRITE ih VALENCE 1
RANGE gkhbar,ih,g
GLOBAL rinf
}
INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}
PARAMETER {
v (mV)
p = 5 (degC)
dt (ms)
gkhbar = 0.000005 (mho/cm2)
eh = -32.9 (mV)
t1 = 1 (ms)
t2 = 1
t3 = -0.116 (1/mV)
t4 = -17.9
t5 = 1
t6 = 0.09 (1/mV)
t7 = -1.84
t8 = 100 (ms)
}
STATE {
r
}
ASSIGNED {
ih (mA/cm2)
rinf
tau_r (ms)
g (S/cm2)
}
BREAKPOINT {
SOLVE state METHOD cnexp
ih = gkhbar*r*(v - eh)
g = gkhbar*r
}
INITIAL {
rates(v, t1, t2, t3, t4, t5, t6, t7, t8)
r = rinf
}
DERIVATIVE state { :Computes state variable h at current v and dt.
rates(v, t1, t2, t3, t4, t5, t6, t7, t8)
r' = (rinf - r)/tau_r
}
UNITSOFF
PROCEDURE rates(v(mV), t1 (ms), t2, t3(1/mV), t4, t5, t6(1/mV), t7, t8(ms)) {
rinf = 1/(1 + exp((v+84)/10.2))
tau_r = t1/(t2*exp(t3*v+t4)+t5*exp(t6*v+t7)) + t8 + 1e-8
}
UNITSON