TITLE slowly activating potassium current (M-current)
COMMENT
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reference: Yamada, Koch & Adams (1989)
Methods in Neuronal Modeling, MIT press
found in: bullfrog sympathetic ganglion cells
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Assembled for MyFirstNEURON by Arthur Houweling
ENDCOMMENT
INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}
NEURON {
SUFFIX iM
USEION k READ ek WRITE ik
RANGE gkbar, m_inf, tau_m, ik
}
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
}
PARAMETER {
v (mV)
celsius (degC)
dt (ms)
ek (mV)
gkbar= 0.00031 (mho/cm2)
}
STATE {
m
}
ASSIGNED {
ik (mA/cm2)
m_inf
tau_m (ms)
tau_h (ms)
tadj
}
BREAKPOINT {
SOLVE states :METHOD euler
ik = gkbar * m * (v+105)
}
:DERIVATIVE states {
: evaluate_fct(v)
:
: m'= (m_inf-m) / tau_m
:}
PROCEDURE states() {
evaluate_fct(v)
m= m + (1-exp(-dt/tau_m))*(m_inf-m)
}
UNITSOFF
INITIAL {
tadj = 3^((celsius-23.5)/10)
evaluate_fct(v)
m = m_inf
}
PROCEDURE evaluate_fct(v(mV)) { LOCAL a,b
tau_m = 1000.0/(3.3*(exp((v+35)/20)+exp(-(v+35)/20))) / tadj
m_inf = 1.0 / (1+exp(-(v+35)/10))
}
UNITSON