TITLE LVA calcium current (CaLVA) of deep cerebellar nucleus (DCN) neuron
COMMENT
Translated from GENESIS by Johannes Luthman and Volker Steuber.
ENDCOMMENT
NEURON {
SUFFIX CaL
USEION call READ calli, callo WRITE icall VALENCE 2
RANGE gbar, m, h, icall
GLOBAL qdeltat
}
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
}
PARAMETER {
qdeltat = 1
gbar = 1e-5 (siemens/cm2)
calli (mM)
callo (mM)
carev (mV)
}
ASSIGNED {
v (mV)
icall (mA/cm2)
minf
hinf
taum (ms)
tauh (ms)
}
STATE {
m
h
}
INITIAL {
rate(v)
m = minf
h = hinf
}
BREAKPOINT {
SOLVE states METHOD cnexp
carev = 139 : (1e3) * (R*(celsius+273.15))/(2*FARADAY) * log (cao/cai)
icall = gbar * m*m * h * (v - carev)
}
DERIVATIVE states {
rate(v)
m' =(minf - m)/taum
h' =(hinf - h)/tauh
}
PROCEDURE rate(v(mV)) {
TABLE minf, taum, hinf, tauh FROM -150 TO 100 WITH 300
minf = 1 / (1 + exp((v + 56) / -6.2))
taum = 0.333 / (exp((v + 131) / -16.7) + exp((v + 15.8) / 18.2)) + 0.204
taum = taum / qdeltat
hinf = 1 / (1 + exp((v + 80) / 4))
if (v < -81) {
tauh = 0.333 * exp((v + 466) / 66)
} else {
tauh = 0.333 * exp((v + 21) / -10.5) + 9.32
}
tauh = tauh / qdeltat
}