#include "iostream.h" //#include "../define.h" #include "../Neuron.h" #include "../Synapse.h" #include "../HHneuron/HHneuron.h" #include "modelGABABsynapse.h" #include"../rk4.h" #include "GABABsynapse.h" GABABsynapse::GABABsynapse():Synapse(){} GABABsynapse::GABABsynapse(Neuron *obj1,Neuron *obj2,double a):Synapse(obj1,obj2,GB_DIM,GB_PAR) { Evalid=Isynvalid=0; //int i; xnew=new double[Dimno]; extra=new double[2]; x=new double[Parno]; dx=new double[Dimno]; parameter=new double[Parno]; extra[0]=extra[1]=0; x[0]=.005; x[1]=.002; parameter[0]=a; parameter[1]=-80; parameter[2]=.09; parameter[3]=.0012; parameter[4]=2; parameter[5]=5; parameter[6]=.18; parameter[7]=.034; } GABABsynapse::GABABsynapse(Neuron *obj1,Neuron *obj2,double *a,double *b):Synapse(obj1,obj2,GB_DIM,GB_PAR) { Evalid=Isynvalid=0; int i; xnew=new double[Dimno]; extra=new double[2]; x=new double[Parno]; dx=new double[Dimno]; parameter=new double[Parno]; extra[0]=extra[1]=0; for(i=0;i<Dimno;i++) x[i]=a[i]; for(i=0;i<Parno;i++) //parameter 0 is the synaptic strength and parameter 1 is parameter[i]=b[i]; // Ereversal for the synapse,parameter 2 is Vth of GABABsynapse } //parameter 3 is synaptic timescale for synapse GABABsynapse::~GABABsynapse() { delete x; delete dx; delete parameter; delete extra; delete xnew; } void GABABsynapse::setvalues(Neuron *obj1, Neuron *obj2,double *a,double *b) { int i; Evalid=Isynvalid=0; source=obj1; target=obj2; source->axon.add(this); target->den.add(this); Dimno=GB_DIM; Parno=GB_PAR; xnew=new double[Dimno]; extra=new double[2]; x=new double[Parno]; dx=new double[Dimno]; parameter=new double[Parno]; extra[0]=extra[1]=0; for(i=0;i<Dimno;i++) x[i]=a[i]; for(i=0;i<Parno;i++) //parameter 0 is the synaptic strength and parameter 1 is parameter[i]=b[i]; } void GABABsynapse::update(double timestep) { step(timestep,x,dx,parameter,extra,xnew,Dimno,&t,&modelGABABsynapse); Isynvalid=1; } void GABABsynapse::steptime() { assert(Isynvalid); for(int i=0;i<Dimno;i++) { x[i]=xnew[i]; } Evalid=Isynvalid=0; } void GABABsynapse::getvol() { if(!Evalid) { extra[1]=source->E(); } Evalid=1; } double GABABsynapse::Isyn() { double Isync; Isync=-parameter[0]*pow(x[1],4.)/(5.+pow(x[1],4.))*(target->E()-parameter[1]); return(Isync); } /* x[0]=the synaptic open channel probability parameter[0]=synaptic max cinductance parameter[1]=synaptic reversal potential parameter[2]= alpha term for rise time for open channel parameter[3]=beta term for fall time of open channel parameter[4]=Vp..the threshold for activation of open channel probability (default=2) parameter[5]=Kp---normalizing factor (default 5) parameter[6]=K3 term for x[1] dynamics parameter[7]=K4 term for x[1] dynamics */