#include "NMDA.h"
#include <math.h>
#include <stdio.h>
#include "../Constants.h"
NMDA::NMDA() {
R = 0, C = 0, R0 = 0, R1 = 0;
lastrelease = -100;
lastspike = -100;
s = 0;
Rinf = Cmax*Alpha / (Cmax*Alpha + Beta);
Rtau = 1 / ((Alpha * Cmax) + Beta);
E = 1;
Use = F_USE_SPIKE;
Tr = TAU_STD;
I = 0;
}
double NMDA::E_NMDA = 0, NMDA::Cdur = 0.3, NMDA::Cmax = 0.5;
double NMDA::Deadtime = 1;
double NMDA::Cdel = 2;
double NMDA::Alpha = 1, NMDA::Beta = 0.0067; // alpha = 1(0.25); beta = 0.0067 (0.025)
void NMDA::calc(double g_NMDA, double x, double y_post,
double prespiketime, int FD) {
q = ((x - lastrelease) - Cdur);
if(q > Deadtime) {
if( (x - prespiketime)<0.002 ) {
if( (x - lastspike) > (Cdel + Cdur) ){
lastspike = x;
s = 1; } } //the flag that spike was but wasn't utilized
if((s == 1) && ((x - lastspike) > Cdel)) {
s = 0; //spike was utilized
C = Cmax;
R0 = R;
if (FD==1) {
E = 1 - (1 - E*(1-Use)) * exptable(-q/Tr);
} else {
E = 1;
}
lastrelease = x; }
} else if (q < 0) {
} else if (C == Cmax) {
R1 = R;
C = 0.;
}
if (C > 0) {
R = Rinf + (R0 - Rinf) * exptable (-(x - lastrelease) / Rtau);
} else {
R = R1 * exptable (-Beta * (x - (lastrelease + Cdur)));
}
fn = 1/(1+exp(-(y_post - (-25))/12.5));
I = g_NMDA * R * fn * E * (y_post - E_NMDA);
}
double NMDA::exptable(double z) {
if((z > -10) && (z < 10)) return( exp(z) );
else return(0);
}