TITLE Sodium transient current for RD Traub, J Neurophysiol 89:909-921, 2003
COMMENT
Implemented by Maciej Lazarewicz 2003 (mlazarew@seas.upenn.edu)
ENDCOMMENT
INDEPENDENT { t FROM 0 TO 1 WITH 1 (ms) }
UNITS {
(mV) = (millivolt)
(mA) = (milliamp)
}
NEURON {
SUFFIX naf
USEION na READ ena WRITE ina
RANGE gbar, ina
}
PARAMETER {
fastNashift = -3.5 (mV)
gbar = 0.0 (mho/cm2)
v ena (mV)
}
ASSIGNED {
ina (mA/cm2)
minf hinf (1)
mtau htau (ms)
}
STATE {
m h
}
BREAKPOINT {
SOLVE states METHOD cnexp
ina = gbar * m * m * m * h * ( v - ena )
}
INITIAL {
settables( v - fastNashift )
m = minf
m = 0
h = hinf
}
DERIVATIVE states {
settables( v )
m' = ( minf - m ) / mtau
h' = ( hinf - h ) / htau
}
UNITSOFF
PROCEDURE settables(v1(mV)) {
TABLE minf, hinf, mtau, htau FROM -120 TO 40 WITH 641
minf = 1 / ( 1 + exp( ( - ( v1 + fastNashift ) - 38 ) / 10 ) )
if( ( v1 + fastNashift ) < -30.0 ) {
mtau = 0.025 + 0.14 * exp( ( ( v1 + fastNashift ) + 30 ) / 10 )
} else{
mtau = 0.02 + 0.145 * exp( ( - ( v1 + fastNashift ) - 30 ) / 10 )
}
: hinf, and htau are shifted 3.5 mV comparing to the paper
hinf = 1 / ( 1 + exp( ( ( v1 + fastNashift * 0 ) + 62.9 ) / 10.7 ) )
htau = 0.15 + 1.15 / ( 1 + exp( ( ( v1 + fastNashift * 0 ) + 37 ) / 15 ) )
}
UNITSON