TITLE delayed rectifier K channel Traub
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
(S) = (siemens)
(mS) = (millisiemens)
}
NEURON {
THREADSAFE
: note - every variable accessible in NEURON will be having the suffix _gKdr
SUFFIX gKdr
USEION k READ ek WRITE ik
RANGE gmax, g, i, tau_n, n_inf
: GLOBAL n_inf, tau_n
}
PARAMETER {
gmax=0.015 (mho/cm2) : value at soma
}
STATE {
n
}
ASSIGNED {
v (mV)
ek (mV)
ik (mA/cm2)
n_inf (1)
tau_n (ms)
g (S/cm2)
i (mA/cm2)
}
BREAKPOINT {
SOLVE states METHOD cnexp
g = gmax*n
i = g*(v-ek)
ik = i
}
INITIAL {
rates(v)
n = n_inf
}
FUNCTION alpha_n(v(mV)) {
alpha_n = 0.016*(35.1-v)/(exp( (35.1-v)/5 ) - 1)
}
FUNCTION beta_n(v(mV)) {
beta_n = 0.25*exp( (20 - v)/40 )
}
DERIVATIVE states {
rates(v)
n' = (n_inf - n)/tau_n
}
PROCEDURE rates(v (mV)) { :callable from hoc
LOCAL alpha, beta
TABLE n_inf, tau_n : DEPEND vhalfn, vhalfl, tlmax, tnmax
FROM -20 TO 130 WITH 750
alpha = alpha_n(v)
beta = beta_n(v)
tau_n = 1/(alpha + beta)
n_inf = alpha*tau_n
}