: simple first-order model of calcium dynamics
NEURON {
SUFFIX cadyn
USEION ca READ cai,ica WRITE cai
RANGE ca
GLOBAL depth,cainf,taur
}
UNITS {
(molar) = (1/liter)
(mM) = (milli/liter)
(um) = (micron)
(mA) = (milliamp)
(msM) = (ms mM)
FARADAY = (faraday) (coul)
}
PARAMETER {
depth = .1 (um)
taur = 200 (ms)
cainf = 50e-6 (mM)
cai (mM)
}
ASSIGNED {
ica (mA/cm2)
drive_channel (mM/ms)
}
STATE {
ca (mM)
}
BREAKPOINT {
SOLVE state METHOD euler
}
DERIVATIVE state {
drive_channel = - (10000) * ica / (2 * FARADAY * depth)
if (drive_channel <= 0.) { drive_channel = 0. }
ca' = drive_channel/18 + (cainf - ca)/taur*11
cai = ca
}
INITIAL {
ca = cainf
}