//Template for the detailed FS Somogyi_1!
//Alexandra Tzilivaki
begintemplate FScell
external v_init
objref unscrProx, unscrDist
objref all, somatic, axonal, basal_prox, basal_dist
//Public members need to be declared afterwards:
public soma, axon, dend
public init //enables the init() to be called again after object is created!
public all, somatic, axonal, basal_prox, basal_dist
public dendproxNo, denddistNo
public unscrProx, unscrDist
//Initial creation necessary (segmentation violation error otherwise):
create soma, axon, dend
proc init () {
print "Opening gjhui", $s1
//The right amount of compartments is declared per object instance inside
//the loaded morphology script:
xopen($s1) // !!
dendproxNo=0
denddistNo=0
//Create public members for the number of proximal (distal) dendrites,
//accessible through dot notation (i.e. myFS.dendproxNo):
forsec basal_prox dendproxNo = dendproxNo + 1
forsec basal_dist denddistNo = denddistNo + 1
//Define electrophysiological properties:
//..........................................................................................................................................................................
soma_Nafin= 0.045/*//*0.025//0.060*3*/
soma_kdrin=0.018*2//*0.028//0.0018*2
soma_Kslowin=0.000725/*//*0.1//*0.00006*0.1//0.000725*0.1 //*0.1 9/12/15*/
soma_hin=0.00001/*//*10//*100//*100//*100//*/
soma_kapin=0.0032//*2//*0.1//*2//*0.001
soma_can=0.0003//*2 alexandra 17/12/2015
soma_cat=0.001*2 //for dends
soma_kctin=0.0001//*10//100//*100//*10
soma_kcain=20*0.001//..001//0.5//*0
//...........................................................................................................................................................................
forsec somatic {
nseg= 5 //1 12/16
insert pas
cm=1.2//microF/cm2
g_pas =1/7600
e_pas = v_init
Ra=172 //(Noerenberg et al, 2010 PNAS)
insert Nafx
gnafbar_Nafx= soma_Nafin*0.8*11
insert kdrin
gkdrbar_kdrin= soma_kdrin*1.2
insert IKsin
gKsbar_IKsin= soma_Kslowin
insert hin
gbar_hin=soma_hin
insert kapin
gkabar_kapin=soma_kapin
insert kctin
gkcbar_kctin=soma_kctin
insert kcain
gbar_kcain=soma_kcain
insert cadynin // cai
}
forsec axonal {
nseg=10
insert pas
cm=1.2
g_pas =1/281600
e_pas = v_init
Ra=172
insert Nafx
gnafbar_Nafx=soma_Nafin*0.8*36
insert kdrin
gkdrbar_kdrin=soma_kdrin*4
}
forsec basal_prox {
nseg=5
insert pas
cm=1.2//microF/cm2
g_pas =1/7600
e_pas = v_init
Ra=142
insert Nafx
gnafbar_Nafx=soma_Nafin*0.4//*1.2
insert kdrin
gkdrbar_kdrin=0.018*0.5
insert kapin
gkabar_kapin=soma_kapin*0.2//*1.2
insert can
gcabar_can = soma_can
insert cat
gcatbar_cat=soma_cat*0.1
insert cal
gcalbar_cal=0.00003 // L type calcium channel
insert cadynin
}
forsec basal_dist {
nseg=5
insert pas
cm=1.2 //microF/cm2
g_pas =1/74300
e_pas = v_init
Ra=142
insert Nafx
gnafbar_Nafx=soma_Nafin*0.4*0.8
insert kdrin
gkdrbar_kdrin=0.018*0.5
insert kadin
gkabar_kadin=1.8*0.001//*1.2 // IA current used in distal regions >100 microns from the soma
insert cat
gcatbar_cat=soma_cat*0.1
insert can
gcabar_can=soma_can
insert cal
gcalbar_cal=0.00003
insert cadynin
}
ko0_k_ion = 3.82 //mM
ki0_k_ion = 140 //mM
} //end init()
endtemplate FScell