/* Created by Language version: 6.2.0 */
/* NOT VECTORIZED */
#define NRN_VECTORIZED 0
#include <stdio.h>
#include <stdlib.h>
#include <math.h>
#include "scoplib_ansi.h"
#undef PI
#define nil 0
#include "md1redef.h"
#include "section.h"
#include "nrniv_mf.h"
#include "md2redef.h"
#if METHOD3
extern int _method3;
#endif
#if !NRNGPU
#undef exp
#define exp hoc_Exp
extern double hoc_Exp(double);
#endif
#define nrn_init _nrn_init__kca
#define _nrn_initial _nrn_initial__kca
#define nrn_cur _nrn_cur__kca
#define _nrn_current _nrn_current__kca
#define nrn_jacob _nrn_jacob__kca
#define nrn_state _nrn_state__kca
#define _net_receive _net_receive__kca
#define rates rates__kca
#define states states__kca
#define _threadargscomma_ /**/
#define _threadargsprotocomma_ /**/
#define _threadargs_ /**/
#define _threadargsproto_ /**/
/*SUPPRESS 761*/
/*SUPPRESS 762*/
/*SUPPRESS 763*/
/*SUPPRESS 765*/
extern double *getarg();
static double *_p; static Datum *_ppvar;
#define t nrn_threads->_t
#define dt nrn_threads->_dt
#define gbar _p[0]
#define ik _p[1]
#define po _p[2]
#define m _p[3]
#define ek _p[4]
#define cai _p[5]
#define ki _p[6]
#define ko _p[7]
#define Dm _p[8]
#define _g _p[9]
#define _ion_ko *_ppvar[0]._pval
#define _ion_ki *_ppvar[1]._pval
#define _ion_ik *_ppvar[2]._pval
#define _ion_dikdv *_ppvar[3]._pval
#define _ion_cai *_ppvar[4]._pval
#if MAC
#if !defined(v)
#define v _mlhv
#endif
#if !defined(h)
#define h _mlhh
#endif
#endif
#if defined(__cplusplus)
extern "C" {
#endif
static int hoc_nrnpointerindex = -1;
/* external NEURON variables */
extern double celsius;
/* declaration of user functions */
static void _hoc_rates(void);
static int _mechtype;
extern void _nrn_cacheloop_reg(int, int);
extern void hoc_register_prop_size(int, int, int);
extern void hoc_register_limits(int, HocParmLimits*);
extern void hoc_register_units(int, HocParmUnits*);
extern void nrn_promote(Prop*, int, int);
extern Memb_func* memb_func;
extern void _nrn_setdata_reg(int, void(*)(Prop*));
static void _setdata(Prop* _prop) {
_p = _prop->param; _ppvar = _prop->dparam;
}
static void _hoc_setdata() {
Prop *_prop, *hoc_getdata_range(int);
_prop = hoc_getdata_range(_mechtype);
_setdata(_prop);
hoc_retpushx(1.);
}
/* connect user functions to hoc names */
static VoidFunc hoc_intfunc[] = {
"setdata_kca", _hoc_setdata,
"rates_kca", _hoc_rates,
0, 0
};
/* declare global and static user variables */
#define b b_kca
double b = 0.008;
#define m_inf m_inf_kca
double m_inf = 0;
#define taumin taumin_kca
double taumin = 0;
#define tau_m tau_m_kca
double tau_m = 0;
/* some parameters have upper and lower limits */
static HocParmLimits _hoc_parm_limits[] = {
0,0,0
};
static HocParmUnits _hoc_parm_units[] = {
"tau_m_kca", "ms",
"taumin_kca", "ms",
"b_kca", "/ms",
"gbar_kca", "mho/cm2",
"ik_kca", "mA/cm2",
0,0
};
static double delta_t = 0.01;
static double m0 = 0;
static double v = 0;
/* connect global user variables to hoc */
static DoubScal hoc_scdoub[] = {
"m_inf_kca", &m_inf_kca,
"tau_m_kca", &tau_m_kca,
"taumin_kca", &taumin_kca,
"b_kca", &b_kca,
0,0
};
static DoubVec hoc_vdoub[] = {
0,0,0
};
static double _sav_indep;
static void nrn_alloc(Prop*);
static void nrn_init(_NrnThread*, _Memb_list*, int);
static void nrn_state(_NrnThread*, _Memb_list*, int);
static void nrn_cur(_NrnThread*, _Memb_list*, int);
static void nrn_jacob(_NrnThread*, _Memb_list*, int);
static int _ode_count(int);
static void _ode_map(int, double**, double**, double*, Datum*, double*, int);
static void _ode_spec(_NrnThread*, _Memb_list*, int);
static void _ode_matsol(_NrnThread*, _Memb_list*, int);
#define _cvode_ieq _ppvar[5]._i
static void _ode_matsol_instance1(_threadargsproto_);
/* connect range variables in _p that hoc is supposed to know about */
static const char *_mechanism[] = {
"6.2.0",
"kca",
"gbar_kca",
0,
"ik_kca",
"po_kca",
0,
"m_kca",
0,
0};
static Symbol* _k_sym;
static Symbol* _ca_sym;
extern Prop* need_memb(Symbol*);
static void nrn_alloc(Prop* _prop) {
Prop *prop_ion;
double *_p; Datum *_ppvar;
_p = nrn_prop_data_alloc(_mechtype, 10, _prop);
/*initialize range parameters*/
gbar = 10;
_prop->param = _p;
_prop->param_size = 10;
_ppvar = nrn_prop_datum_alloc(_mechtype, 6, _prop);
_prop->dparam = _ppvar;
/*connect ionic variables to this model*/
prop_ion = need_memb(_k_sym);
nrn_promote(prop_ion, 1, 0);
_ppvar[0]._pval = &prop_ion->param[2]; /* ko */
_ppvar[1]._pval = &prop_ion->param[1]; /* ki */
_ppvar[2]._pval = &prop_ion->param[3]; /* ik */
_ppvar[3]._pval = &prop_ion->param[4]; /* _ion_dikdv */
prop_ion = need_memb(_ca_sym);
nrn_promote(prop_ion, 1, 0);
_ppvar[4]._pval = &prop_ion->param[1]; /* cai */
}
static void _initlists();
/* some states have an absolute tolerance */
static Symbol** _atollist;
static HocStateTolerance _hoc_state_tol[] = {
0,0
};
static void _update_ion_pointer(Datum*);
extern Symbol* hoc_lookup(const char*);
extern void _nrn_thread_reg(int, int, void(*)(Datum*));
extern void _nrn_thread_table_reg(int, void(*)(double*, Datum*, Datum*, _NrnThread*, int));
extern void hoc_register_tolerance(int, HocStateTolerance*, Symbol***);
extern void _cvode_abstol( Symbol**, double*, int);
void _kca_reg() {
int _vectorized = 0;
_initlists();
ion_reg("k", -10000.);
ion_reg("ca", -10000.);
_k_sym = hoc_lookup("k_ion");
_ca_sym = hoc_lookup("ca_ion");
register_mech(_mechanism, nrn_alloc,nrn_cur, nrn_jacob, nrn_state, nrn_init, hoc_nrnpointerindex, 0);
_mechtype = nrn_get_mechtype(_mechanism[1]);
_nrn_setdata_reg(_mechtype, _setdata);
_nrn_thread_reg(_mechtype, 2, _update_ion_pointer);
hoc_register_prop_size(_mechtype, 10, 6);
hoc_register_dparam_semantics(_mechtype, 0, "k_ion");
hoc_register_dparam_semantics(_mechtype, 1, "k_ion");
hoc_register_dparam_semantics(_mechtype, 2, "k_ion");
hoc_register_dparam_semantics(_mechtype, 3, "k_ion");
hoc_register_dparam_semantics(_mechtype, 4, "ca_ion");
hoc_register_dparam_semantics(_mechtype, 5, "cvodeieq");
hoc_register_cvode(_mechtype, _ode_count, _ode_map, _ode_spec, _ode_matsol);
hoc_register_tolerance(_mechtype, _hoc_state_tol, &_atollist);
hoc_register_var(hoc_scdoub, hoc_vdoub, hoc_intfunc);
ivoc_help("help ?1 kca /home/cluster/aleka/MainPath/Desktop/FSBC_model/Multicompartmental_Biophysical_models/mechanism/x86_64/kca.mod\n");
hoc_register_limits(_mechtype, _hoc_parm_limits);
hoc_register_units(_mechtype, _hoc_parm_units);
}
static int _reset;
static char *modelname = "Slow Ca-dependent potassium current";
static int error;
static int _ninits = 0;
static int _match_recurse=1;
static void _modl_cleanup(){ _match_recurse=1;}
static int rates(double);
static int _ode_spec1(_threadargsproto_);
/*static int _ode_matsol1(_threadargsproto_);*/
static int _slist1[1], _dlist1[1];
static int states(_threadargsproto_);
/*CVODE*/
static int _ode_spec1 () {_reset=0;
{
rates ( _threadargscomma_ cai ) ;
Dm = ( m_inf - m ) / tau_m ;
}
return _reset;
}
static int _ode_matsol1 () {
rates ( _threadargscomma_ cai ) ;
Dm = Dm / (1. - dt*( ( ( ( - 1.0 ) ) ) / tau_m )) ;
return 0;
}
/*END CVODE*/
static int states () {_reset=0;
{
rates ( _threadargscomma_ cai ) ;
m = m + (1. - exp(dt*(( ( ( - 1.0 ) ) ) / tau_m)))*(- ( ( ( m_inf ) ) / tau_m ) / ( ( ( ( - 1.0 ) ) ) / tau_m ) - m) ;
}
return 0;
}
static int rates ( double _lcai ) {
double _la ;
_la = _lcai / b ;
m_inf = _la / ( _la + 1.0 ) ;
tau_m = taumin + 1.0 * 1.0 * b / ( _lcai + b ) ;
return 0; }
static void _hoc_rates(void) {
double _r;
_r = 1.;
rates ( *getarg(1) );
hoc_retpushx(_r);
}
static int _ode_count(int _type){ return 1;}
static void _ode_spec(_NrnThread* _nt, _Memb_list* _ml, int _type) {
Datum* _thread;
Node* _nd; double _v; int _iml, _cntml;
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
_nd = _ml->_nodelist[_iml];
v = NODEV(_nd);
ko = _ion_ko;
ki = _ion_ki;
cai = _ion_cai;
_ode_spec1 ();
}}
static void _ode_map(int _ieq, double** _pv, double** _pvdot, double* _pp, Datum* _ppd, double* _atol, int _type) {
int _i; _p = _pp; _ppvar = _ppd;
_cvode_ieq = _ieq;
for (_i=0; _i < 1; ++_i) {
_pv[_i] = _pp + _slist1[_i]; _pvdot[_i] = _pp + _dlist1[_i];
_cvode_abstol(_atollist, _atol, _i);
}
}
static void _ode_matsol_instance1(_threadargsproto_) {
_ode_matsol1 ();
}
static void _ode_matsol(_NrnThread* _nt, _Memb_list* _ml, int _type) {
Datum* _thread;
Node* _nd; double _v; int _iml, _cntml;
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
_nd = _ml->_nodelist[_iml];
v = NODEV(_nd);
ko = _ion_ko;
ki = _ion_ki;
cai = _ion_cai;
_ode_matsol_instance1(_threadargs_);
}}
extern void nrn_update_ion_pointer(Symbol*, Datum*, int, int);
static void _update_ion_pointer(Datum* _ppvar) {
nrn_update_ion_pointer(_k_sym, _ppvar, 0, 2);
nrn_update_ion_pointer(_k_sym, _ppvar, 1, 1);
nrn_update_ion_pointer(_k_sym, _ppvar, 2, 3);
nrn_update_ion_pointer(_k_sym, _ppvar, 3, 4);
nrn_update_ion_pointer(_ca_sym, _ppvar, 4, 1);
}
static void initmodel() {
int _i; double _save;_ninits++;
_save = t;
t = 0.0;
{
m = m0;
{
rates ( _threadargscomma_ cai ) ;
m = 0.0 ;
}
_sav_indep = t; t = _save;
}
}
static void nrn_init(_NrnThread* _nt, _Memb_list* _ml, int _type){
Node *_nd; double _v; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
v = _v;
ko = _ion_ko;
ki = _ion_ki;
cai = _ion_cai;
initmodel();
}}
static double _nrn_current(double _v){double _current=0.;v=_v;{ {
ek = 25.0 * log ( ko / ki ) ;
po = m * m ;
ik = gbar * po * ( v - ek ) ;
}
_current += ik;
} return _current;
}
static void nrn_cur(_NrnThread* _nt, _Memb_list* _ml, int _type){
Node *_nd; int* _ni; double _rhs, _v; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
ko = _ion_ko;
ki = _ion_ki;
cai = _ion_cai;
_g = _nrn_current(_v + .001);
{ double _dik;
_dik = ik;
_rhs = _nrn_current(_v);
_ion_dikdv += (_dik - ik)/.001 ;
}
_g = (_g - _rhs)/.001;
_ion_ik += ik ;
#if CACHEVEC
if (use_cachevec) {
VEC_RHS(_ni[_iml]) -= _rhs;
}else
#endif
{
NODERHS(_nd) -= _rhs;
}
}}
static void nrn_jacob(_NrnThread* _nt, _Memb_list* _ml, int _type){
Node *_nd; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml];
#if CACHEVEC
if (use_cachevec) {
VEC_D(_ni[_iml]) += _g;
}else
#endif
{
_nd = _ml->_nodelist[_iml];
NODED(_nd) += _g;
}
}}
static void nrn_state(_NrnThread* _nt, _Memb_list* _ml, int _type){
Node *_nd; double _v = 0.0; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
_nd = _ml->_nodelist[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
v=_v;
{
ko = _ion_ko;
ki = _ion_ki;
cai = _ion_cai;
{ error = states();
if(error){fprintf(stderr,"at line 52 in file kca.mod:\n SOLVE states METHOD cnexp\n"); nrn_complain(_p); abort_run(error);}
} }}
}
static void terminal(){}
static void _initlists() {
int _i; static int _first = 1;
if (!_first) return;
_slist1[0] = &(m) - _p; _dlist1[0] = &(Dm) - _p;
_first = 0;
}