:fast potassium current from A. Korngreen and B. Sackmann, "Voltage-gated K+ channels in layer 5 neocortical pyramidal neurons rom young rats: subtypes and gradients", J. Physiol. 2000, 525, 621-639
NEURON {
SUFFIX kslow
USEION k READ ek WRITE ik
RANGE gbar, g, i
}
UNITS {
(S) = (siemens)
(mV) = (millivolt)
(mA) = (milliamp)
}
PARAMETER {
gbar = 6.59090909e-5 (S/cm2) :aus dem Paper abgeschrieben
eK = -95 (mV)
}
ASSIGNED {
v (mV)
ek (mV)
ik (mA/cm2)
i (mA/cm2)
g (S/cm2)
}
STATE {m h}
BREAKPOINT {
SOLVE states METHOD cnexp
g = gbar*h*m*m :ist das second-order ?
i = g*(v-eK)
ik = i
}
INITIAL {
m = minf(v)
h = hinf(v)
}
DERIVATIVE states {
m'= (minf(v)-m)/mtau(v)
h'= (hinf(v)-h)/htau(v)
}
FUNCTION minf (Vm (mV)) () {
UNITSOFF
minf = 1/(1+exp(-(Vm+14.3)/14.6)) :oder sollte hier die Potenz 2 stehen ?
UNITSON
}
FUNCTION mtau (Vm (mV)) (ms) {
UNITSOFF
:kleiner 50 mV dann
if (Vm < 50) {
mtau = 1.25+1.15*exp(-0.026*Vm) :deactication
} else {
mtau = 1.25+13*exp(-0.026*Vm) :activation
}
UNITSON
}
FUNCTION hinf (Vm (mV)) () {
UNITSOFF
hinf = 1/(1+exp((Vm+54)/11)) :aus der Tabelle pharmacological seperation, kinetic seperation: -51 und -12
UNITSON
}
FUNCTION htau (Vm (mV)) (ms) {
UNITSOFF
htau = 360+(1010+24*(Vm+55))*exp(-((Vm+75)/48)*((Vm+75)/48))
UNITSON
}