/************************************************************
Christina Weaver
August 2011
insert channels from Vetter et al (2001) into dlPFC
cortical pyramidal neuron from J Luebke. Includes Mainen's
synthetic axon (from the 1995 Mainen et al. paper).
************************************************************/
load_file("nrngui.hoc")
// now load morph; recall that 'basic_shape()' resets the morphology
load_file("Jul16IR3f_fromSWCthenManual_Nov22-11.hoc")
load_file("aux_procs.hoc")
{ncp = 0 forall ncp += nseg }
printf("Before correction ncp = %d\n",ncp)
xopen("electro_procs.hoc")
V1_effective_ApicalSpineDensity = 0.67322181 // total of 1153 spines, divided by total apical length
V1_effective_BasalSpineDensity = 0.4886992 // total of 874 spines, divided by total basal length
applySubtreeConstantSpineDensity(apical, SurfaceAreaOneApicalSpine, V1_effective_ApicalSpineDensity)
applySubtreeConstantSpineDensity(basal, SurfaceAreaOneBasalSpine, V1_effective_BasalSpineDensity)
geom_nseg(100,0.1)
{ncp = 0 forall ncp += nseg }
printf("After correction ncp = %d\n",ncp)
// Using SEClamp, as recommended on the NEURON User Forum. See init_PFC.hoc for details.
load_file("rigPFCmod.ses")
INITDUR = 80 //50
VO = -70
V0 = -70 //avoid ambiguity of "Capital O" vs "zero 0"
//reduce soma size
soma.L *= 0.66667
soma.diam *= 0.66667
set_epasNG(69)
scale_gpas(3.8e-5)
//set_epasNG(72)
//scale_gpas(4.8e-5)
scaleNa(105,1e3)
scaleKV(115,16.6667)
// inject several levels of current injection, and record the firing rates that come out.
load_file("custominit.hoc")
load_file("batchrun.hoc")
tstop = 1200
dt=0.05
steps_per_ms = 20
forall { if( ismembrane("na") ) vshift_na=-10.5 }
for( iVal=.03; iVal<=.28; iVal = iVal+.05) {
run_1Step(200,700,iVal)
}