/************************ VTA v2.14 Ka.g *********************
*****Equations and Parameters for Ka channel*****
Rebekah Evans rebekah.evans@nih.gov
**************************************************************************/
//data from Rahilla Tarfa
function make_Ka_channel
float Erev = -0.09 //Volts
str path = "Ka_channel"
float xmin = -0.10 /* minimum voltage we will see in the simulation */ // Volts
float xmax = 0.05 /* maximum voltage we will see in the simulation */ // Volts
int xdivsFiner = 3000
int c = 0
float increment = (xmax - xmin)*1e3/xdivsFiner // mV
float mhalf = -29.4172
float mslope = 8.43839
float mrate = 1
float hhalf = -61.1714
float hslope = -4.57317
float hrate = 1
create tabchannel {path}
call {path} TABCREATE X {xdivsFiner} {xmin} {xmax} // activation gate
call {path} TABCREATE Y {xdivsFiner} {xmin} {xmax} // inactivation gate
float x = -100.00 // mV
echo "Make Ka channel"
for(c = 0; c < {xdivsFiner} + 1; c = c + 1)
float minfa = {boltz {mrate} {mhalf} {mslope} {x}}
float minf = {pow {minfa} 0.3333333333} //takes cubed root so mpower of 3 makes correct activation curve
float m_tau = {Ka_tau {1} {50} {550} {x}} //from kusnetsova 2010
float hinf = {boltz {hrate} {hhalf} {hslope} {x}}
float h_tau = 200 //150 //100 //50 //25
/* 1e-3 converts from ms to sec for taus*/
setfield {path} X_A->table[{c}] {1e-3*{m_tau}}
setfield {path} X_B->table[{c}] {minf}
setfield {path} Y_A->table[{c}] {1e-3*{h_tau}}
setfield {path} Y_B->table[{c}] {hinf}
x = x + increment
end
setfield {path} Ek {Erev} Xpower 3 Ypower 1
tweaktau {path} X
tweaktau {path} Y
end