/************************ VTA v2.14 SK.g *********************
*****Equations and Parameters for small conductance calcium activated potassium channel*****
*****SK is calcium, but not voltage dependent*****
Rebekah Evans rebekah.evans@nih.gov
**************************************************************************/
//Reference: Maylie,Bond,Herson,Lee,Adelman,2004
//implemented in Evans et al. 2013
function make_SK_channel
str path = "SK_channel"
float Erev = -0.090
int nStep = 3000
float SKact = 0.0
float CaMax = 0.1 // 100 uM
float CaMax = 0.006 // 6 uM
float CaMin = 1e-6 //1 nM
float CaMin = 0
float delta = (CaMax - CaMin)/nStep
float theta = 0.0
float theta_pow = 0.0
float Kd = 0.57e-3
int i
float Ca = 0.0
create tabchannel {path}
setfield {path} Ek {Erev} Zpower 1
call {path} TABCREATE Z {nStep} {CaMin} {CaMax} // Creates nStep entries
for (i = 0; i < {nStep}; i = i + 1)
Ca=i*delta
theta = {Ca/Kd}
theta_pow = { pow {theta} 5.2}
SKact = theta_pow/{1 + theta_pow}
setfield {path} Z_A->table[{i}] {4.9e-3} // Fast component, tau=4.9ms from Hirschberg et al., 1998 figure 13.
setfield {path} Z_B->table[{i}] {SKact} //from Maylie et al., 2004 figure 2
end
tweaktau {path} Z
end