/************************ VTA v2.14 SK.g ********************* *****Equations and Parameters for small conductance calcium activated potassium channel***** *****SK is calcium, but not voltage dependent***** Rebekah Evans rebekah.evans@nih.gov **************************************************************************/ //Reference: Maylie,Bond,Herson,Lee,Adelman,2004 //implemented in Evans et al. 2013 function make_SK_channel str path = "SK_channel" float Erev = -0.090 int nStep = 3000 float SKact = 0.0 float CaMax = 0.1 // 100 uM float CaMax = 0.006 // 6 uM float CaMin = 1e-6 //1 nM float CaMin = 0 float delta = (CaMax - CaMin)/nStep float theta = 0.0 float theta_pow = 0.0 float Kd = 0.57e-3 int i float Ca = 0.0 create tabchannel {path} setfield {path} Ek {Erev} Zpower 1 call {path} TABCREATE Z {nStep} {CaMin} {CaMax} // Creates nStep entries for (i = 0; i < {nStep}; i = i + 1) Ca=i*delta theta = {Ca/Kd} theta_pow = { pow {theta} 5.2} SKact = theta_pow/{1 + theta_pow} setfield {path} Z_A->table[{i}] {4.9e-3} // Fast component, tau=4.9ms from Hirschberg et al., 1998 figure 13. setfield {path} Z_B->table[{i}] {SKact} //from Maylie et al., 2004 figure 2 end tweaktau {path} Z end