TITLE Calcium high-threshold current
COMMENT
from Table 3 of "A branching dendritic model of a rodent CA3 pyramidal neurone." Traub RD et al. J Physiol. (1994)
implemented by Nikita Vladimirov <nikita.vladimirov@gmail.com>
ENDCOMMENT
NEURON {
SUFFIX Ca
USEION ca WRITE ica
RANGE gbar, g, i, minf
GLOBAL Vm, Eca
}
UNITS {
(S) = (siemens)
(mA) = (milliamp)
(mV) = (millivolt)
}
PARAMETER {
gbar = 0 (S/cm2)
Vm = -65 (mV) : resting potential
Eca = 75 (mV) : Ca reversal potential, absolute (140 mV relative to Vm)
}
ASSIGNED {
v (mV)
ica (mA/cm2)
i (mA/cm2)
g (S/cm2)
minf
mtau (ms)
}
STATE { m }
BREAKPOINT {
SOLVE states METHOD cnexp
g = gbar * m^2
i = g * (v - Eca)
ica = i
}
INITIAL {
rates(v)
m = minf
}
DERIVATIVE states {
rates(v)
m' = (minf - m) / mtau
}
PROCEDURE rates(v(mV)) {
LOCAL alpham, betam, small
TABLE minf, mtau FROM -100 TO 50 WITH 200
UNITSOFF
alpham = 1.6 / ( 1 + exp(-0.072 * (v - Vm - 65)) )
small = (v - Vm - 51.1) / 5
if( fabs(small) > 1e-6 ) {
betam = 0.02 * (v - Vm - 51.1) / ( exp( (v - Vm - 51.1) / 5 ) - 1)
} else {
betam = 0.02 * 5 / ( 1 + small / 2 )
}
minf = alpham / ( alpham + betam )
mtau = 1 / ( alpham + betam )
UNITSON
}