TITLE Fast sodium current, for axonal compartments
COMMENT
from Table 4 of "A branching dendritic model of a rodent CA3 pyramidal neurone." Traub RD et al. J Physiol. (1994)
implemented by Nikita Vladimirov <nikita.vladimirov@gmail.com>
ENDCOMMENT
NEURON {
SUFFIX NaFax
USEION na READ ena WRITE ina
RANGE gbar, g, i
GLOBAL Vm
}
UNITS {
(S) = (siemens)
(mA) = (milliamp)
(mV) = (millivolt)
}
PARAMETER {
gbar = 0 (S/cm2)
Vm = -65 (mV) : resting potential
}
ASSIGNED {
v (mV)
ena (mV)
ina (mA/cm2)
i (mA/cm2)
g (S/cm2)
minf
hinf
mtau (ms)
htau (ms)
}
STATE { m h }
BREAKPOINT {
SOLVE states METHOD cnexp
g = gbar * m^3 * h
i = g * (v - ena)
ina = i
}
INITIAL {
rates(v)
m = minf
h = hinf
}
DERIVATIVE states {
rates(v)
m' = (minf - m) / mtau
h' = (hinf - h) / htau
}
PROCEDURE rates(v(mV)) {
LOCAL alpham, betam, alphah, betah, small
TABLE minf, mtau, hinf, htau FROM -100 TO 50 WITH 200
UNITSOFF
small = (17.2 - (v - Vm) )/4
if ( fabs(small) > 1e-6 ) {
alpham = 0.8 * (17.2 - (v - Vm) ) / ( exp( (17.2 - (v - Vm) )/4 ) - 1 )
} else {
alpham = 0.8 * 4 / (1 + small/2)
}
small = ( (v - Vm) - 42.2)/5
if ( fabs(small) > 1e-6 ) {
betam = 0.7 * ( (v - Vm) - 42.2) / ( exp( ( (v - Vm) - 42.2)/5 ) - 1 )
} else {
betam = 0.7 * 5 / ( 1 + small/2 )
}
minf = alpham / ( alpham + betam )
mtau = 1 / ( alpham + betam )
alphah = 0.32 * exp( (42 - (v - Vm) ) / 18 )
betah = 10 / ( 1 + exp( (42 - (v - Vm) )/5 ) )
hinf = alphah / ( alphah + betah )
htau = 1 / ( alphah + betah )
UNITSON
}