COMMENT
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from ModelDB:
Uebachs M, Opitz T, Royeck M, Dickhof G, Horstmann MT, Isom LL, Beck H (2010)
Efficacy Loss of the Anticonvulsant Carbamazepine in Mice Lacking Sodium Channel
beta Subunits via Paradoxical Effects on Persistent Sodium Currents. J Neurosci 30:8489-501
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ENDCOMMENT
TITLE nap
NEURON {
SUFFIX nap
USEION na READ ena WRITE ina
RANGE gbar, thegna, sh, scalerate
GLOBAL minf, mtau
:, hinf, mtau, htau
}
PARAMETER {
gbar = .0052085 (mho/cm2)
sh = 0 (mV)
eNa = 55 (mV)
scalerate = 1 (ms)
ena (mV)
celsius (degC)
v (mV)
}
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
(pS) = (picosiemens)
(um) = (micron)
}
ASSIGNED {
ina (mA/cm2)
thegna (mho/cm2)
minf
mtau (ms)
}
STATE { m }
UNITSOFF
BREAKPOINT {
SOLVE states METHOD cnexp
thegna =gbar*m
ina = thegna * (v - eNa)
}
INITIAL {
mtau = scalerate
minf = (1/(1+exp(-(v+52.3-sh)/6.8)))
m=minf
}
DERIVATIVE states {
mtau = scalerate
minf = (1/(1+exp(-(v+52.3-sh)/6.8)))
m' = (minf-m)/mtau
}
UNITSON