NEURON files from the paper: Ingrid van Welie, Michiel W.H. Remme, Johannes A. van Hooft, and Wytse J. Wadman Different levels of Ih determine distinct temporal integration in bursting and regular-spiking neurons in rat subiculum, Journal of Physiology (2006). DOI:10.1113/jphysiol.2006.1139441 The subiculum.hoc file will run four 800ms simulations plotting the membrane potential at the soma The cell morphology is the one illustrated in figure 6A (now with the axon). The morphology of this typical subiculum neuron is given in the S40.hoc file The simulation produces part of the data illustrated in figure 6D and 6E. Regular and burst firing pyramidal neurons from the subiculum differ in the levels of Ih. In the simulations a fraction of the AMPA synapses distributed over the apical dendrites are simultaneously activated at eiter 20 Hz or 50 Hz in both types of neurons. The simulations support the experimental results from the paper, illustrating that the different densities of Ih affect the summation of the synaptic input when recorded from the soma. Under unix systems: to compile the mod files use the command nrnivmodl and run the simulation hoc file with the command nrngui subiculum.hoc Under Windows systems: to compile the mod files use the "mknrndll" command. A double click on the simulation file subiculum.hoc will open the simulation window. Questions on how to use this model should be directed to wadman@science.uva.nl