// NEURON 001
// ------------------------
// General notes and instructions
// ------------------------
// Loads the base neuron and sets its parameters
// Loads with the xopen command:
// xopen("NEURON_001-130308.hoc")
// A base neuron such as this should be loaded first
// Some variable names differ from those mentioned in
// Young, Castelfranco, Hartline (2013).
// 'mye' refers to the "myelinated" segments, i.e. the
// internodes.
// 'gap' refers to the thickness of the submyelin space,
// i.e. the submyelin gap, or delta.
// 'mycm' is the radial capacitance of a single layer
// of "myelin"
// 'mygm' is the radial conductance of a single layer
// of "myelin"
// ------------------------
// Base neuron setup
// ------------------------
segs = 100
create node[segs+1]
create para[2*segs]
create mye[segs]
rhoa = 0.356e6
rhoo = 0.356e6
axondiam = 10
gap = 0.07
Rnumber = (rhoo*0.01)/(PI*((((axondiam/2)+gap)^2)-((axondiam/2)^2)))
nl = 100
mycm = 1.0
mygm = 0.000001
for i = 0, (segs-1) {
node[i] {
L = 10
diam = axondiam
Ra = rhoa*0.0001
cm = 1
nseg = 9
insert hh
gnabar_hh = 0.12
gkbar_hh = 0.036
gl_hh = 0.0003
el_hh = -54.4
insert extracellular
xraxial = 0.0001
xg = 1e10
xc = 0
}
para[2*i] {
L = 1
diam = axondiam
Ra = rhoa*0.0001
cm = 1
nseg = 3
insert hh
gnabar_hh = 0.12
gkbar_hh = 0.036
gl_hh = 0.0003
el_hh = -54.4
insert extracellular
xraxial = Rnumber
xg = mygm/(nl*2)
xc = mycm/(nl*2)
}
mye[i] {
L = 1500
diam = axondiam
Ra = rhoa*0.0001
cm = 1
nseg = 301
insert hh
gnabar_hh = 0.12
gkbar_hh = 0.036
gl_hh = 0.0003
el_hh = -54.4
insert extracellular
xraxial = Rnumber
xg = mygm/(nl*2)
xc = mycm/(nl*2)
}
para[2*i+1] {
L = para[2*i].L
diam = para[2*i].diam
Ra = para[2*i].Ra
cm = para[2*i].cm
nseg = para[2*i].nseg
insert hh
gnabar_hh = para[2*i].gnabar_hh
gkbar_hh = para[2*i].gkbar_hh
gl_hh = para[2*i].gl_hh
el_hh = para[2*i].el_hh
insert extracellular
xraxial = para[2*i].xraxial
xg = para[2*i].xg
xc = para[2*i].xc
}
connect para[2*i](0), node[i](1)
connect mye[i](0), para[2*i](1)
connect para[2*i+1](0), mye[i](1)
}
for i = 1, (segs-1) {
connect node[i](0), para[2*i-1](1)
}
node[segs] {
L = node[0].L
diam = node[0].diam
Ra = node[0].Ra
cm = node[0].cm
nseg = node[0].nseg
insert hh
gnabar_hh = node[0].gnabar_hh
gkbar_hh = node[0].gkbar_hh
gl_hh = node[0].gl_hh
el_hh = node[0].el_hh
insert extracellular
xraxial = node[0].xraxial
xg = node[0].xg
xc = node[0].xc
}
connect node[segs](0), para[2*segs-1](1)