TITLE K-DR channel
: from Klee Ficker and Heinemann
: modified to account for Dax et al.
: M.Migliore 1997
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
}
PARAMETER {
v (mV)
ek (mV) : must be explicitely def. in hoc
celsius (degC)
gkdrbar=.003 (mho/cm2)
vhalfn=13 (mV)
a0n=0.02 (/ms)
zetan=-3 (1)
gmn=0.7 (1)
:gmn=1
nmax=0.10 (ms) : was 2 for pureSK
tau (ms)
q10=1
}
NEURON {
SUFFIX kdr
USEION k READ ek WRITE ik
RANGE gkdr,gkdrbar,tau,ik
}
STATE {
n
}
ASSIGNED {
ik (mA/cm2)
ninf
taun (ms)
gkdr (mho/cm2)
}
BREAKPOINT {
SOLVE states METHOD cnexp
tau = 0.7*betn(v)/(0.02*(1+ exp(-339.44*(v-13)/(8.315*(273.16+celsius))) ))
gkdr = gkdrbar*n
ik = gkdr*(v-ek)
}
INITIAL {
rates(v)
n=ninf
}
FUNCTION alpn(v(mV)) {
LOCAL Arg
Arg=1.e-3*zetan*(v-vhalfn)*9.648e4/(8.315*(273.16+celsius))
if (Arg<-50) {alpn=0}
else if (Arg>50) {alpn=exp(50)}
else {alpn=exp(Arg)}
}
FUNCTION betn(v(mV)) {
LOCAL Arg
Arg=1.e-3*zetan*gmn*(v-13)*9.648e4/(8.315*(273.16+celsius))
if (Arg<-50) {betn=0}
else if (Arg>50) {betn=exp(50)}
else {betn=exp(Arg)}
}
DERIVATIVE states { : exact when v held constant; integrates over dt step
rates(v)
n' = (ninf - n)/taun
}
PROCEDURE rates(v (mV)) { :callable from hoc
LOCAL a,c,qt, Arg
qt=q10^((celsius-24)/10)
a = alpn(v)
ninf = 1/(1+a)
Arg=-339.44*(v-13)/(8.315*(273.16+celsius))
if (Arg<-50) {c=0}
else if (Arg>50) {c=exp(50)}
else {c=exp(Arg)}
taun = 0.7*betn(v)/(qt*a0n*(1+c))
: taun = betn(v)/(qt*a0n*(1+a))
if(taun<nmax) {taun=nmax}
: if(v<-55) {taun=0.01}
}